Herpes simplex virus infection in women with previous spontaneous abortion

Bujko, M; Sulović, V; Živanovic, Vera; Dotlić, R; Bardič, Ivana

doi:10.1515/jpme.1988.16.3.193

Cited by 12 publications

(7 citation statements)

References 6 publications

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“…In some reports the association between ma-Sifakis/Koumantakis/Koffa/Ergazaki/ Spandidos ternal primary infection prior to 20 weeks and the possibility of a spontaneous abortion is emphasized [13][14][15] but this has not been confirmed by other investigators [16]. It has been proposed that a latent endometrial HSV infection may be reactivated and affect the amniochorion and chorionic villi destroying the embryo (blighted ovum) [15].…”

Section: Discussionmentioning

confidence: 99%

“…A correlation between HSV and spontaneous abortions has been reported although the data are mainly epidemiological and controversial [13][14][15][16]. HSV possesses certain clinical properties and specific features which lead some investigators to believe that a significant proportion of the 40% of spontaneous abortions of unknown aetiology may be caused by this virus [15].…”

Section: Introductionmentioning

confidence: 99%

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Detection of Herpes simplex Virus (HSV) in Aborted Material Using the Polymerase Chain Reaction Technique

Sifakis

Koumantakis

Koffa

et al. 1998

Gynecol Obstet Invest

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Objective: To investigate the contribution of HSV to the aetiopathogenesis of spontaneous abortion. Design: A hospital-based, case-control study. Setting: Department of Obstetrics and Gynecology, University Hospital and Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece. Population and Methods: Abortion material from 102 cases of women with spontaneous abortion was analysed for the presence of HSV DNA applying the PCR technique. Serological assays were used for the detection of specific IgM and IgG antibodies in the maternal sera of 90 pregnant women with successful outcome of their pregnancy while 70 non-pregnant women at reproductive age were also examined as control. Results: The HSV genome was detected by PCR amplification in 3 cases of spontaneous abortion, 2 of them exhibited serological markers of virus reactivation while the 3rd showed a past infection. There were no obvious clinical manifestations indicating a current herpes infection. Both groups of pregnant women, either with spontaneous abortion or with a successful outcome of pregnancy, displayed serological markers of HSV reactivation at higher rates compared with non-pregnant women (χ², p < 0.05). Conclusions: Using the PCR technique we were able to detect the HSV genome in gestational tissues of spontaneous abortions, even in cases without any clinical symptoms or seropositivity for a primary infection. Serological assays were not very useful for the elucidation of the role of HSV in inducing spontaneous abortions, although they indicate that the state of pregnancy predisposes to HSV reactivation. However, the detection of HSV in 3 out of a total number of 102 cases does not support HSV infection as a major abortion-related factor.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of Herpes simplex Virus (HSV) in Aborted Material Using the Polymerase Chain Reaction Technique

Sifakis

Koumantakis

Koffa

et al. 1998

Gynecol Obstet Invest

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“…Herpes antigens have been found by immunocytochemistry [2,3] and HSV DNA has been detected by PCR [4] in spontaneous and therapeutic abortions. Also, when compared with an uninfected control population, a significant increase of spontaneous abortions was described in women with latent HSV‐2 genital infections (diagnosed by a microneutralization test) [5]. Preterm delivery and low infant birth weight were reported in women with HSV asymptomatic genital shedding [6].…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis of herpes simplex virus type 2 experimental genital infection in pregnant mice

Sanjuán

Zimberlin

2001

FEMS Immunol Med Microbiol

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The progression of herpes simplex-2 genital infection in pregnant mice was studied by detection of viral antigens using immunoperoxidase in tissue sections, electron microscopy and virus isolation. The majority of mice (66.66%) died at 8-9 days post-inoculation. Abortions were observed in 69.23% of the infected mice along with impairment of labor and delivery. Herpes antigens were detected in most of the autonomic nerves of the uterus, including those surrounding small arterioles in the myometrium and the Auerbach and Meissner plexa of the large bowel, but not in the abortions or placentas. The infection of uterine autonomic fibers and myometrial cells could explain the delivery impairment and could have provoked a decrease in blood flow leading to abortions.

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“…At the level of the individual patient, genital herpes is associated with significant psychological morbidity and complications such as neonatal herpes, the result of transmission of HHSV from mother to baby (11,12) . The incidence of asymptomatic cervical HHSV-2 infections was considerably higher in patients with a history of spontaneous abortion with a possible etiologic connection between human herpesvirus and spontaneous abortion (13) .…”

Section: Introductionmentioning

confidence: 94%

Frequency of Human Cytomegalovirus and Human Herpesvirus-1 Antigens in Product of Conceptus Tissues of Pregnant Women With Spontaneous Abortion

2017

IJMS

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Herpes simplex virus infection in women with previous spontaneous abortion

Cited by 12 publications

References 6 publications

Detection of Herpes simplex Virus (HSV) in Aborted Material Using the Polymerase Chain Reaction Technique

Detection of Herpes simplex Virus (HSV) in Aborted Material Using the Polymerase Chain Reaction Technique

Pathogenesis of herpes simplex virus type 2 experimental genital infection in pregnant mice

Frequency of Human Cytomegalovirus and Human Herpesvirus-1 Antigens in Product of Conceptus Tissues of Pregnant Women With Spontaneous Abortion

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