Herpes Simplex Virus Infection in Heart-Lung Transplant Recipients

Smyth, Rosalind L; Higenbottam, T. W.; Scott, John; Wreghitt, T.G.; Stewart, Susan; Clelland, Colin; McGoldrick, John; Wallwork, J.

doi:10.1097/00007890-199004000-00016

Cited by 88 publications

(56 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Findings on CT scan of the abdomen may be helpful by demonstrating diffuse microabscesses ( Figure 1B) that reflect the tissue necrosis typically produced by HSV ( Figure 1C). HSV pneumonia has a particular predilection for thoracic organ recipients (18,21,32) and is rare in other solid organ transplant groups (33). A summary of heart, lung and heart-lung recipients over 5 years (18,21) reported seven cases of HSV pneumonia in 70 patients before the institution of acyclovir prophylaxis.…”

Section: Clinical Manifestations Of Hsv Diseasementioning

confidence: 99%

“…HSV pneumonia has a particular predilection for thoracic organ recipients (18,21,32) and is rare in other solid organ transplant groups (33). A summary of heart, lung and heart-lung recipients over 5 years (18,21) reported seven cases of HSV pneumonia in 70 patients before the institution of acyclovir prophylaxis. All cases were seropositive prior to transplant, consistent with recent data (9) that oral and tracheal shedding generally precedes lower respiratory tract disease in critically ill, intubated patients.…”

Section: Clinical Manifestations Of Hsv Diseasementioning

confidence: 99%

“…In a randomized, placebo-controlled trial of acyclovir in HSV seropositive renal transplant recipients (34), 14 of 21 placebo recipients developed culture positive lesions within 28 days posttransplant. HSV pneumonia likewise occurs within the first 1-2 months posttransplant (18,21,35). The early onset simplifies prophylaxis since it provides a relatively narrow window when treatment is required.…”

Section: Timing Of Disease Onsetmentioning

confidence: 99%

See 2 more Smart Citations

Herpes Simplex and Varicella Zoster Viruses: Forgotten but Not Gone

Miller

Dummer

2007

American Journal of Transplantation

103

View full text Add to dashboard Cite

Herpesvirus infections are common complications of organ transplantation. The most frequent herpesvirus infections are caused by cytomegalovirus (CMV), herpes simplex (HSV) and varicella zoster (VZV). Despite expansion of the therapeutic armamentarium, HSV and VZV continue to cause morbidity and occasional mortality in transplant recipients. Here we review the incidence and risk factors for HSV and VZV disease, their clinical presentation, effects of newer immunosuppressive regimens and prophylaxis for HSV and VZV in solid organ transplant recipients.

show abstract

Section: Clinical Manifestations Of Hsv Diseasementioning

confidence: 99%

Section: Clinical Manifestations Of Hsv Diseasementioning

confidence: 99%

Section: Timing Of Disease Onsetmentioning

confidence: 99%

See 1 more Smart Citation

Herpes Simplex and Varicella Zoster Viruses: Forgotten but Not Gone

Miller

Dummer

2007

American Journal of Transplantation

103

View full text Add to dashboard Cite

show abstract

“…Lesions (13,14). Fever, leucopenia and hepatitis are common presenting signs of disseminated disease.…”

Section: A Minority Of Immunocompetent Persons Infected With Hsv Devementioning

confidence: 99%

“…Fever, leucopenia and hepatitis are common presenting signs of disseminated disease. Pneumonitis is described in recipients of all organ types, but is most common in heart-lung recipients (14). (8,9,15 (9,18,19 (25).…”

Section: A Minority Of Immunocompetent Persons Infected With Hsv Devementioning

confidence: 99%

Herpes Simplex Virus Infections in Solid Organ Transplant Recipients

Zuckerman

Wald

2009

American Journal of Transplantation

View full text Add to dashboard Cite

Comparison of Posttransplant Dermatologic Diseases by Race

et al. 2017

View full text Add to dashboard Cite

IMPORTANCE The risk for skin cancer has been well characterized in white organ transplant recipients (OTRs); however, most patients on the waiting list for organ transplant in the United States are nonwhite. Little is known about cutaneous disease and skin cancer risk in this OTR population. OBJECTIVE To compare the incidence of cutaneous disease between white and nonwhite OTRs. DESIGN, SETTING, AND PARTICIPANTS This retrospective review of medical records included 412 OTRs treated from November 1, 2011, through April 22, 2016, at an academic referral center. Prevalence and characteristics of cutaneous disease were compared in 154 white and 258 nonwhite (ie, Asian, Hispanic, and black) OTRs. Clinical factors of cutaneous disease and other common diagnoses assessed in OTRs included demographic characteristics, frequency and type of cancer, anatomical location, time course, sun exposure, risk awareness, and preventive behavior. MAIN OUTCOMES AND MEASURES Primary diagnosis of malignant or premalignant, infectious, and inflammatory disease. RESULTS The 412 patients undergoing analysis included 264 men (64.1%) and 148 women (35.9%), with a mean age of 60.1 years (range, 32.1-94.3 years). White OTRs more commonly had malignant disease at their first visit (82 [67.8%]), whereas nonwhite OTRs presented more commonly with infectious (63 [37.5%]) and inflammatory (82 [48.8%]) conditions. Skin cancer was diagnosed in 64 (41.6%) white OTRs and 15 (5.8%) nonwhite OTRs. Most lesions in white (294 of 370 [79.5%]) and Asian (5 of 6 [83.3%]) OTRs occurred in sun-exposed areas. Among black OTRs, 6 of 9 lesions (66.7%) occurred in sun-protected areas, specifically the genitals. Fewer nonwhite than white OTRs reported having regular dermatologic examinations (5 [11.4%] vs 8 [36.4%]) and knowing the signs of skin cancer (11 [25.0%] vs 10 [45.4%]). CONCLUSIONS AND RELEVANCE Early treatment of nonwhite OTRs should focus on inflammatory and infectious diseases. Sun protection should continue to be emphasized in white, Asian, and Hispanic OTRs. Black OTRs should be counseled to recognize the signs of genital human papillomavirus infection. Optimal posttransplant dermatologic care may be determined based on the race or ethnicity of the patients, but a baseline full-skin assessment should be performed in all patients. All nonwhite OTRs should be counseled more effectively on the signs of skin cancer, with focused discussion points contingent on skin type and race or ethnicity.

show abstract

Herpes Simplex Virus Infection in Heart-Lung Transplant Recipients

Cited by 88 publications

References 0 publications

Herpes Simplex and Varicella Zoster Viruses: Forgotten but Not Gone

Herpes Simplex and Varicella Zoster Viruses: Forgotten but Not Gone

Herpes Simplex Virus Infections in Solid Organ Transplant Recipients

Comparison of Posttransplant Dermatologic Diseases by Race

Contact Info

Product

Resources

About