Abstract:Herpes simplex virus type 2 was isolated and identified from the vesicular border of pyoderma gangrenosum lesions on the genital region of a patient with chronic lymphatic leukemia. Dramatic relief of pain as well as quick disappearance of the vesicular margin of the lesions and of the inflammatory halo around them occurred as a result of local treatment with a solution of zinc acetate. A careful search for a viral agent should be done in every case of pyoderma gangrenosum occurring in a patient with a hematol… Show more
“…Pyoderma gangrenosum, of which only one case has been published in the literature, 19 is rare although it is frequently observed in the myeloproliferative syndromes.Kaposi's sarcoma 21,22 and cutaneous cancers of all types (basal‐cell epitheliomas, squamous‐cell carcinomas, and melanomas) are more frequent than in the normal population 20 23 pemphigus vulgaris, 24 and rheumatoid arthritis 25 ), in which pure coincidence cannot be excluded due to a limited number of observations, are rare.Angioedema with acquired C1‐esterase inhibitor deficiency was reported twice 26,27 …”
Section: Associated Lesionsmentioning
confidence: 99%
“…Pyoderma gangrenosum, of which only one case has been published in the literature, 19 is rare although it is frequently observed in the myeloproliferative syndromes.…”
Cutaneous lesions arising during the course of chronic lymphocytic leukemia (CLL), generally of the B-cell type, are frequent. Three types of cutaneous manifestations must be differentiated: (1) specific lesions, (2) cutaneous manifestations closely related to the disease but without a leukemoid infiltrate and (3) associations with various dermatologic conditions. The various clinical features are discussed.
“…Pyoderma gangrenosum, of which only one case has been published in the literature, 19 is rare although it is frequently observed in the myeloproliferative syndromes.Kaposi's sarcoma 21,22 and cutaneous cancers of all types (basal‐cell epitheliomas, squamous‐cell carcinomas, and melanomas) are more frequent than in the normal population 20 23 pemphigus vulgaris, 24 and rheumatoid arthritis 25 ), in which pure coincidence cannot be excluded due to a limited number of observations, are rare.Angioedema with acquired C1‐esterase inhibitor deficiency was reported twice 26,27 …”
Section: Associated Lesionsmentioning
confidence: 99%
“…Pyoderma gangrenosum, of which only one case has been published in the literature, 19 is rare although it is frequently observed in the myeloproliferative syndromes.…”
Cutaneous lesions arising during the course of chronic lymphocytic leukemia (CLL), generally of the B-cell type, are frequent. Three types of cutaneous manifestations must be differentiated: (1) specific lesions, (2) cutaneous manifestations closely related to the disease but without a leukemoid infiltrate and (3) associations with various dermatologic conditions. The various clinical features are discussed.
“…The first case dates from 1979, when Wahba et al described a patient with chronic lymphatic leukemia and HSV-2 isolated from genital PG. In that instance, Authors recommended to carefully research viruses in patients with PG and impaired immunity or hematological malignancy, mainly if face or genital area are involved (6). Furthermore, in 2005, Tay et al reported the case of a man with resistant PG complicated by HSV-1 infection, whose late recognition led to the ulcer progression (7).…”
SummaryPyoderma gangrenosum is a neutrophilic dermatosis that can be idiopathic or associated with other conditions such as hematologic malignancies. Both diseases require the use of immunosuppressive therapies that predispose patients to opportunistic infections, that sometimes have atypical presentation. We describe a case of genital pyoderma gangrenosum complicated by herpes simplex virus infection in a 69-year-old woman with chronic myeloid leukaemia.
“…A case of pyoderma gangrenosum involved in female genitalia was reported in Korea (8). Two reported cases of penile pyoderma gangranosum were associated with systemic chronic lymphocytic leukemia (9) and ulcerative colitis (10) respectively, but the others occurred without any associated diseases. Pyoderma gangranosum is a disease entity diagnosed when other causes of purulent ulcerations, such as STD, multi-system disease, necrotizing faciitis, cutaneous metastatic Crohn's disease, deep fungal infection, pemphigus vegetans, Fournier's gangrene, neoplastic conditions, erosive lichen planus, trauma and factitious damage have been excluded.…”
We report a patient who developed pyoderma gangrenosum in the penis with invasion of the distal urethra. The patient was treated with prednisolone and thalidomide, followed by a reconstructive surgical repair using a scrotal island flap. We report this case with a brief review of the literature.
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