Herpes Zoster and Multiple Sclerosis

Corona, Teresa; Flores, José de Jesús Vargas

doi:10.1093/infdis/jir243

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…The potential role of VZV in the pathogenesis of multiple sclerosis (MS) has been a subject of extensive research and speculation, although the precise mechanism of its involvement remains a topic of ongoing investigation and debate in the scientific community 127 . Findings from epidemiological investigations have indicated a plausible association between VZV infection and the pathogenesis of MS 128 . The vast majority (95.1%) of MS patients in a case‐control study conducted in northern Iran tested positive for anti‐VZV antibodies, while 26.1% tested positive for VZV DNA.…”

Section: Role Of Vzv Infection In Inflammatory Neurological Diseasesmentioning

confidence: 99%

Varicella‐zoster virus‐related neurological complications: From infection to immunomodulatory therapies

Hakami,

Khan,

Abdulaziz

et al. 2024

Reviews in Medical Virology

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The Varicella‐zoster virus (VZV), classified as a neurotropic member of the Herpesviridae family, exhibits a characteristic pathogenicity, predominantly inducing varicella, commonly known as chickenpox, during the initial infectious phase, and triggering the reactivation of herpes zoster, more commonly recognized as shingles, following its emergence from a latent state. The pathogenesis of VZV‐associated neuroinflammation involves a complex interplay between viral replication within sensory ganglia and immune‐mediated responses that contribute to tissue damage and dysfunction. Upon primary infection, VZV gains access to sensory ganglia, establishing latent infection within neurons. During reactivation, the virus can spread along sensory nerves, triggering a cascade of inflammatory mediators, chemokines, and immune cell infiltration in the affected neural tissues. The role of both adaptive and innate immune reactions, including the contributions of T and B cells, macrophages, and dendritic cells, in orchestrating the immune‐mediated damage in the central nervous system is elucidated. Furthermore, the aberrant activation of the natural defence mechanism, characterised by the dysregulated production of immunomodulatory proteins and chemokines, has been implicated in the pathogenesis of VZV‐induced neurological disorders, such as encephalitis, myelitis, and vasculopathy. The intricate balance between protective and detrimental immune responses in the context of VZV infection emphasises the necessity for an exhaustive comprehension of the immunopathogenic mechanisms propelling neuroinflammatory processes. Despite the availability of vaccines and antiviral therapies, VZV‐related neurological complications remain a significant concern, particularly in immunocompromised individuals and the elderly. Elucidating these mechanisms might facilitate the emergence of innovative immunomodulatory strategies and targeted therapies aimed at mitigating VZV‐induced neuroinflammatory damage and improving clinical outcomes. This comprehensive understanding enhances our grasp of viral pathogenesis and holds promise for pioneering therapeutic strategies designed to mitigate the neurological ramifications of VZV infections.

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Section: Role Of Vzv Infection In Inflammatory Neurological Diseasesmentioning

confidence: 99%

Varicella‐zoster virus‐related neurological complications: From infection to immunomodulatory therapies

Hakami,

Khan,

Abdulaziz

et al. 2024

Reviews in Medical Virology

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“…There are also researches on the involvement of varicella zoster virus (VZ) in the etiology of multiple sclerosis. VZ may act as a risk factor in areas where the frequency of multiple sclerosis is low [22]. VZ virus as well as EB is acquired in childhood or adolescence and may remain latent in the host for decades [23].…”

Section: Viral Hypothesis In Multiple Sclerosismentioning

confidence: 99%

“…These particles could cause continuous activation of the immune system affecting immune pathways responsible for the onset of lesions typical of Multiple Sclerosis [14]. Besides, up to 30% of outbreaks of established MS may be associated with acute bacterial or viral infectious processes [22]. Viral infections are also implicated in other CNS demyelinating diseases such as Acute Disseminated Encephalomyelitis (ADEM).…”

Section: Viral Hypothesis In Multiple Sclerosismentioning

confidence: 99%

Is there a Low Risk of Multiple Sclerosis in HIV Patients?

Vilaça

Leite

Fiorelli

et al. 2018

BJSTR

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Objectives: Discuss the hypothesis of HIV infection to reduce the risk of Multiple Sclerosis.Method: Non-systematic review using a Google Scholar platform of articles with the keywords: "HIV" or "Human Immunodeficiency Virus" associated with the term "multiple sclerosis" in the title of the journal.Results and Discussion: 44 articles were used in English language for this manuscript. Conclusion:There are few cases of patients with HIV and multiple sclerosis. The HIV infection may decrease risks of multiple sclerosis. The study of this association may contribute to the understanding of the physiopathology in inflammatory diseases of the central nervous system and the use of drugs for HIV infection in multiple sclerosis.

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Estudio epidemiológico de la esclerosis múltiple en La Rioja

et al. 2015

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Prevalence and incidence are similar to those found in other regions Spain. The average age at onset age for primary progressive MS is slightly higher than in other papers (40-49 years). In families with multiple patients, MS may be more aggressive. Disability in these patients remains very severe. We require more epidemiology studies with a variety of data gathering methods to support findings for prevalence obtained in different provinces.

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Herpes Zoster and Multiple Sclerosis

Cited by 5 publications

References 13 publications

Varicella‐zoster virus‐related neurological complications: From infection to immunomodulatory therapies

Varicella‐zoster virus‐related neurological complications: From infection to immunomodulatory therapies

Is there a Low Risk of Multiple Sclerosis in HIV Patients?

Estudio epidemiológico de la esclerosis múltiple en La Rioja

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