Herpesviruses: General Properties

Viruses are dependent upon the host cell protein synthesis machinery, thus they have developed a range of strategies to manipulate host translation to favour viral protein synthesis. Consequently, the study of viral translation has been a powerful tool for illuminating many aspects of cellular translational control. Although much work to date has focused on translational regulation by RNA viruses, DNA viruses have also evolved complex mechanisms to regulate protein synthesis. Here we summarize work on a large family of DNA viruses, the Herpesviridae, which have evolved mechanisms to sustain efficient cap-dependent translation and to regulate the translation of specific viral mRNAs.

show abstract

“…Eight herpesviruses, representing all three subfamilies, cause disease in humans (Table 1). For reviews of herpesvirus biology, see [1,2].…”

Section: Herpesviridaementioning

confidence: 99%

Regulation of translation initiation by herpesviruses

Smith

Graham

Gray

2008

Biochemical Society Transactions

View full text Add to dashboard Cite

show abstract

“…The Herpesviridae family is subdivided into three subfamilies: Alphaherpesvirinae [e.g., herpes simplex virus type 1 and 2 (HSV-1 and -2), and pseudorabies virus (PRV)], Betaherpesvirinae [e.g., human cytomegalovirus (HCMV) and human herpesvirus type 6], and Gammaherpesvirinae [e.g., Epstein-Barr virus (EBV), and Kaposi’s sarcoma-associated herpesvirus (KSHV)]. The double-stranded DNA genomes of herpesviruses vary within 125–240 kilobase-pairs ( Davison, 2007 ; Davison and Clements, 2010 ). The heart of the viral life cycle is the regulation of transcription.…”

Section: Introductionmentioning

confidence: 99%

Long-Read Sequencing Revealed an Extensive Transcript Complexity in Herpesviruses

Tombácz¹,

Balázs²,

Csabai³

et al. 2018

Front. Genet.

View full text Add to dashboard Cite

Long-read sequencing (LRS) techniques are very recent advancements, but they have already been used for transcriptome research in all of the three subfamilies of herpesviruses. These techniques have multiplied the number of known transcripts in each of the examined viruses. Meanwhile, they have revealed a so far hidden complexity of the herpesvirus transcriptome with the discovery of a large number of novel RNA molecules, including coding and non-coding RNAs, as well as transcript isoforms, and polycistronic RNAs. Additionally, LRS techniques have uncovered an intricate meshwork of transcriptional overlaps between adjacent and distally located genes. Here, we review the contribution of LRS to herpesvirus transcriptomics and present the complexity revealed by this technology, while also discussing the functional significance of this phenomenon.

show abstract

“…Herpesvirus genes are transcribed in the nucleus by cellular RNA polymerase II, resulting in capped and polyadenylated mRNAs (reviewed in [82]). The Herpesviridae family comprises enveloped double-stranded DNA viruses divided into three subfamilies, the Alphaherpesvirinae, Betaherpesvirinae and Gammaherpesvirinae.…”

Section: Pabp Recruitment To Eif4f By Hcmv (Human Cytomegalovirus) Anmentioning

confidence: 99%

Poly(A)-binding protein (PABP): a common viral target

Smith

Gray

2010

Biochemical Journal

View full text Add to dashboard Cite

Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles in mRNA translation and stability. In the present review, we examine recent evidence that the activity of PABP is altered during infection with a wide range of viruses, bringing about changes in its stability, complex formation and intracellular localization. Targeting of PABP by both RNA and DNA viruses highlights the role of PABP as a central regulator of gene expression.

show abstract

Herpesviruses: General Properties

Cited by 10 publications

References 103 publications

Regulation of translation initiation by herpesviruses

Regulation of translation initiation by herpesviruses

Long-Read Sequencing Revealed an Extensive Transcript Complexity in Herpesviruses

Poly(A)-binding protein (PABP): a common viral target

Contact Info

Product

Resources

About