HETEROAROMATIZATION WITH KETENE DITHIOACETALS: PART II. SYNTHESIS OF SOME NOVEL 5-AMINOPYRAZOLE-3-CARBONITRILE, 3-CARBOXAMIDE AND PYRAZOLO[3,4-d]PYRIMIDIN-4-ONE DERIVATIVES AS ANTIMICROBIAL AGENTS

Infrared, Raman and NMR spectra, conformational stability, normal coordinate analysis and B3LYP calculations of 5-amino-4-cyano-3-(methylthio)-1H-pyrazole-1-carbothioamide

“…The solid sample of AMPC was prepared by the reaction of a ketene with a hydrazine derivative using the method described by Hassan et al [44]. A mixture of 0.01 mol 2-(bis(methylthio)methylene)malononitrile, (SCH 3 ) 2 C@C(CN) 2 and 0.01 mol of either (NH 2 NH) 2 CS or NH 2 NHCSNH 2 (thiosemicarbazide) in 30 mL absolute ethanol was refluxed until the evolution of methane thiol cased.…”

Reactions of ketene dithioacetal for a new versatile synthesis of 4,5-substituted 3-aminothiophene-2-carboxylate derivatives

“…[3] Ketene dithioacetals could be used in reactions with various nucleophiles leading to synthesis of a variety of nitrogen heterocycles like pyridines, pyridones, pyrimidines, quinolines, pyrroles, pyrazoles and imidazoles. [1,2,[5][6][7][8][9][10][11] They are used in the synthesis of sulfur containing heterocycles like thiophenes, thiopyrans and other bioactive molecules like cyclopentanoids, polyenes, etc. [1][2][3][4][5][6][7][8][9][10][11] Thiophenes form a major class of bioactive heterocycles.…”

“…[1,2,[5][6][7][8][9][10][11] They are used in the synthesis of sulfur containing heterocycles like thiophenes, thiopyrans and other bioactive molecules like cyclopentanoids, polyenes, etc. [1][2][3][4][5][6][7][8][9][10][11] Thiophenes form a major class of bioactive heterocycles. They show a broad spectrum of biological response such as antibacterial, [12][13][14] anti-leishmanial, [1] antifungal, [1,[12][13][14][15] antimicrobial, [12][13][14][15] antitumor, [16,17] anticancer, [16,17] antiinflammatory, [13,14] antiproliferative, [18] molluscicidal [19] and anticonvulsant activity.…”

Synthesis of Pyrazolo[3,4‐d]pyrimidin‐4‐ones Catalyzed by Br?nsted‐acidic Ionic Liquids as Highly Efficient and Reusable Catalysts

“…Pyrazolo [3,4-d]pyrimidins are one such class of bioactive fused heterocycles with diverse and interesting biological activities. These compounds are reported to possess significant vasodilatory, 11 fungicidal, 12,13 herbicidal, [14][15][16] and antimicrobial [17][18][19] activities. In addition, a number of these compounds are known to inhibit enzymes such as adenosine deaminase, 20 and Plasmodium falciparum PfPK7 protein kinase.…”