“…Multi Component Reaction (MCR) chemistry [ 1 , 2 ] applied to the synthesis of heterocycles [ 3 , 4 , 5 ] with all its variations and extensions has undergone an enormous and meaningful upturn. Seeds sown in the last century, particularly appreciated by Ugi [ 6 ], have grown enormously and provided a plurality of novel reactions, new smart strategies as well as forward-looking methods, and high product diversity [ 7 , 8 ].…”