Heterocyclic substituted ureas. I. Immunosuppression and virus inhibition by benzimidazolylureas

Abstract

Method R. a-(m-Trifluoromethylanilino)phenylacetic Acid.-A solution of m-trifluoromethylaniliue (12.0 g) and o-bromophenylacetic acid (6.5 g) in EtOH (100 ml) was healed at 100°for 5 hr, and the solvent was evaporated at 40°. The residue was

Synthesis and antibacterial activity of some new 1-aroyl-3-(substituted-2-benzothiazolyl)thioureas

“…2-Aminobenzothiazoles are an important five-membered heterocycle used for the treatment of diabetes [18], epilepsy [19], inflammation [20], amyotrophic lateral sclerosis [21], analgesia [22], tuberculosis [23], viral infections [24], and as central muscle relaxants [25]. Riluzole [6-(trifluoromethoxy)-2-benzothiazolamine] [26] possesses potent anticonv-ulsant and neuroprotective effects in vitro [27].…”

β-[1-phenyl-5-bis(β-chloroethyl)-amino-benzimidazolyl-(2)]-Dl-alamine (ZIMET 3164): An immunosuppressant without marked anti-cancer effect

“…Like other benzimidazole derivatives [5,13,15,17,23], ZIMET 3164 showed a dosedependent suppression of humoral antibody formation in the test systems employed. Both primary and secondary immune response were affected and, in contrast to cyclophosphamide [4], the immunological memory, too.…”

Ultrasound-promoted, rapid, green, one-pot synthesis of 2′-aminobenzothiazolomethylnaphthols via a multi-component reaction, catalyzed by heteropolyacid in aqueous media

“…There has been marked interest in the synthesis of 2-aminobenzothiazoles and a significant number of compounds containing this moiety, due to their broad spectrum of biological activities, including anti-inflammatory (Sawhney et al, 1978), anti-carcinogenic (Paget et al, 1982;Tamm et al, 1958;Wells et al, 2000) and anti-viral (Paget et al, 1969) properties. 2-Aminobenzothiazoles are highly reactive compounds.…”