1990
DOI: 10.1016/0360-3016(90)90061-n
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Heterogeneity in tumor microvascular response to radiation

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Cited by 55 publications
(32 citation statements)
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References 26 publications
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“…Extracted biomarkers including the hemoglobin saturation, 44,45 maximum velocity and vessel diameter, 14 and shear rate, 46 are all in qualitative agreement with previous studies that employed different techniques in window chamber tumors, as well as a previous study that employed the same techniques in a different window chamber tumor model. 28 Variations in red blood cell flux and pO 2 , 15 hemoglobin oxygen saturation, 23 and diameter 44 have previously Normalized redox ratio as a function of distance from the nearest vessel for tumors ͑compiled from n = 94 line profiles corresponding to the 94 regions of interest from the three redox animals across the entire tumor time course͒, and for normal tissues ͑compiled from n = 36 line profiles from six regions of interest from each of six normal animals͒.…”
Section: Discussionsupporting
confidence: 83%
See 1 more Smart Citation
“…Extracted biomarkers including the hemoglobin saturation, 44,45 maximum velocity and vessel diameter, 14 and shear rate, 46 are all in qualitative agreement with previous studies that employed different techniques in window chamber tumors, as well as a previous study that employed the same techniques in a different window chamber tumor model. 28 Variations in red blood cell flux and pO 2 , 15 hemoglobin oxygen saturation, 23 and diameter 44 have previously Normalized redox ratio as a function of distance from the nearest vessel for tumors ͑compiled from n = 94 line profiles corresponding to the 94 regions of interest from the three redox animals across the entire tumor time course͒, and for normal tissues ͑compiled from n = 36 line profiles from six regions of interest from each of six normal animals͒.…”
Section: Discussionsupporting
confidence: 83%
“…Blood flow on the microvessel level has traditionally been measured using laser Doppler flowmetry, 7 the dual-slit method, 13 or video microscopy. 14,15 Laser Doppler flowmetry provides a relative ͑not calibrated͒ measurement of blood flow at a single point, and scanning laser Doppler provides an average flow over a tissue area without accounting for contributions from individual vessels. The dual-slit technique and video microscopy both suffer from inaccurate estimations of the length traveled by red blood cells because the length of a 3-D vessel is projected onto a 2-D image, resulting in imprecise velocity values.…”
Section: Introductionmentioning
confidence: 99%
“…The SOD mimic only group appeared to display improved oxygenation as well, consistent with previous findings elucidating its anti-HIF/VEGF effects [92]. Altogether, these results are consistent with previous views regarding post-radiation tumor reoxygenation [90,93,94]. The finding that irradiated tumors increase glucose consumption in the presence of reoxygenation strongly suggests initiation of glycolysis rather than oxidative phosphorylation.…”
Section: Radiation Studiessupporting
confidence: 91%
“…The effect is probably caused by reduction in oxygen consumption rate as a result of death of the more radiosensitive oxygenated tumour cells in addition to an increase in perfusion 130,134,135 . We used the RFP c and GFP h cell lines described above to evaluate the effects of radiation therapy on HIF1 activity 136 .…”
Section: Effects Of Radiation Therapy On Hif1 Activitymentioning
confidence: 99%