Heterogeneous DNA hydrogel loaded with Apt02 modified tetrahedral framework nucleic acid accelerated critical-size bone defect repair

Han, Yafei; Wu, Yan; Wang, Fuxiao; Li, Guangfeng; Wang, Jian; Wu, Xiang; Deng, Anfu; Ren, Xiaoxiang; Wang, Xiuhui; Gao, Jie; Shi, Zhongmin; Bai, Long; Su, Jiacan

doi:10.1016/j.bioactmat.2024.01.009

Cited by 10 publications

(4 citation statements)

References 36 publications

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“…Different types of scaffold systems have been designed to fit specific cell groups, which allow for customization based on individual culture requirements and eliminate the use of a universal ECM surrogate. Seeding molecule-loaded hydrogel microspheres onto human organoid precursors narrows the gap between the in vitro culture systems and in vivo tissues, providing more tunable properties and better therapeutic effects in regenerative medicine [ 205 , 206 ]. To date, a combination of endometrial organoids and hydrogels has been used to study endometriosis [ 55 ], endometrial cancer [ 94 ], IUA [ 164 ], and the decidualization process [ 207 ], which indicates the expanding applicability of organoids to study various endometrial pathologies and their underlying biological mechanisms.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Bioengineering approaches for the endometrial research and application

Dai,

Liang,

Guo

et al. 2024

Materials Today Bio

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Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Bioengineering approaches for the endometrial research and application

Dai,

Liang,

Guo

et al. 2024

Materials Today Bio

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“…Its practical application demonstrates advantages unparalleled by traditional therapies, such as reduced organ damage, lower side effects, reduced likelihood of developing drug resistance, greater efficacy in eradicating residual tumor cells, long-term effectiveness, and prevention of recurrence. [18][19][20][21] However, immunotherapy still carries inherent limitations. Challenges such as specificity issues, low immunogenicity, inadequate delivery efficiency, and off-target side effects remain prominent.…”

Section: Introductionmentioning

confidence: 99%

SOAT1 in gallbladder cancer: Clinicopathological significance and avasimibe therapeutics

Hong,

Abudukeremu,

She

et al. 2024

J Biochem & Molecular Tox

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The aim of this investigation was to evaluate the differential expression of the sterol O‐acyltransferase 1 (SOAT1) protein in gallbladder cancer tissues and cells, investigate the impact of Avastin on the proliferation, migration, invasion capabilities of gallbladder cancer cells, and its potential to induce cell apoptosis. Immunohistochemical analysis of samples from 145 gallbladder cancer patients was conducted, along with analysis of SOAT1 protein, mRNA expression levels, and cholesterol content in gallbladder cancer cell lines SGC‐996, NOZ, and gallbladder cancer (GBC)‐SD using Western blot and q‐PCR techniques. Furthermore, the effects of Avastin on the proliferation, migration, and invasion capabilities of these gallbladder cancer cell lines were studied, and its ability to induce cell apoptosis was evaluated using flow cytometry, Western blot, and immunohistochemical methods. Additionally, gene expression and pathway analysis were performed, and the synergistic therapeutic effects of Avastin combined with gemcitabine were tested in a gallbladder cancer xenograft model. The study found that SOAT1 expression was significantly upregulated in GBC tissues and positively correlated with lymph node metastasis and TNM staging. In vitro experiments demonstrated that Avastin significantly inhibited the proliferation, migration, and invasion capabilities of SGC‐996 and GBC‐SD cell lines and induced apoptosis. RNA sequencing analysis revealed multiple differentially expressed genes in cells treated with Avastin, primarily enriched in biological pathways such as signaling transduction, malignant tumors, and the immune system. In vivo, experiments confirmed that Avastin could effectively suppress tumor growth in a gallbladder cancer xenograft model and enhanced the treatment efficacy when used in combination with gemcitabine. Overall, these findings provide new insights and strategies for targeted therapy in gallbladder cancer.

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“…Most recently, a novel approach has been developed involving polymer-modified DNA hydrogels containing tetrahedral Framework Nucleic Acid (tFNA) and Aptamer02 (Apt02). This approach simultaneously promotes both angiogenesis and osteogenic mineralization and has demonstrated promising efficacy in bone regeneration in rats with critical size bone defects [ 47 ]. However, inconsistent outcomes have also been observed in treatments involving angiogenic factors, particularly regarding blood vessel formation and bone formation in vivo [ 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects

Fang,

Liu,

Wang

et al. 2024

Bioactive Materials

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Heterogeneous DNA hydrogel loaded with Apt02 modified tetrahedral framework nucleic acid accelerated critical-size bone defect repair

Cited by 10 publications

References 36 publications

Bioengineering approaches for the endometrial research and application

Bioengineering approaches for the endometrial research and application

SOAT1 in gallbladder cancer: Clinicopathological significance and avasimibe therapeutics

Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects

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