2021
DOI: 10.21203/rs.3.rs-1105667/v1
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Heterogenous Profiles Between Matched Primary Tumors and Brain Metastases Reveal Tumor Evolution

Abstract: Background: Brain metastases (BMs) are the most common central nervous system (CNS) malignant tumors, with rapid disease progression and extremely poor prognosis. The heterogeneity between primary tumors and BMs leads to the divergent efficacy of the adjuvant therapy response to primary tumors and BMs. However, the extent of heterogeneity between primary tumors and BMs, and the evolutionary process remains little known. Methods: To deeply insight the extent of inter-tumor heterogeneity at single-patient level … Show more

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“…In our work, we mainly test robustness from the prompt design perspective such as how to select in-context examples, the number of in-context examples and the prompt format of in-context examples. It would also be valuable to investigate our prompting methods under different databases, natural language questions, or SQL perturbations (Chang et al, 2023a). This broader exploration would enable us to evaluate the robustness of our prompting methods across diverse scenarios.…”
Section: Limitationsmentioning
confidence: 99%
“…In our work, we mainly test robustness from the prompt design perspective such as how to select in-context examples, the number of in-context examples and the prompt format of in-context examples. It would also be valuable to investigate our prompting methods under different databases, natural language questions, or SQL perturbations (Chang et al, 2023a). This broader exploration would enable us to evaluate the robustness of our prompting methods across diverse scenarios.…”
Section: Limitationsmentioning
confidence: 99%