Heteronuclear metal–organic framework‐based fluorescent sensor for the detection of tetracycline antibiotics

Abstract

The residues of tetracycline antibiotics (TCs) have caused serious environmental pollution due to the multi‐field application. In order to rapidly detect TCs, there is an urgent need to design new fluorescence sensor. Herein, a heterometallic metal‐organic framework (HNU‐61) is constructed and used as a fluorescence sensor for detecting the TCs. In HNU‐61, both Zn2+ and Li+ ions are assembled into the crystal structure, in which Zn2+ adopts tetrahedral coordination mode, and can be served as the potential coordination site. The 3D structure of HNU‐61 is formed by the connection between Zn2+/Li+ and isophthalic acid (m‐BDC2−) ligand with the 1D channel along a axis. Among the six categories of antibiotics, HNU‐61 can effectively detect TCs, including tetracycline hydrochloride (TCY), chlortetracycline hydrochloride (CTE), doxycycline hydrochloride (DOX), and oxytetracycline hydrochloride (OXY) with the detection limits of 6.5 × 10−8 M, 9.2 × 10−8 M, 4.5 × 10−7 M, and 3.9 × 10−7 M, respectively. Furthermore, HNU‐61 enables a rapid and sensitive detection of TCs with good anti‐interference and circulation. The detection mechanism can be attributed to the interaction between Zn2+ in HNU‐61 and TCs.

Antibiotic-Fe3O4 nanoparticles with highly efficient catalytic activity for enhanced chemiluminescence detection of tetracyclines residues in foods

“… Detection method for TCs Detection range (nmol/L) Limit of detection (LOD) (nmol/L) Ref. TC OTC CTC TC OTC CTC CL method 10–2400 10–2800 5–2100 4.0 6.0 2.0 This work HPLC 300–1600 300–1800 300–1700 150 150 150 This work ELISA 0.58–4.5 1.62 7.2 14.4 ( Chen et al, 2015 ) Ratio fluorescence 10–10 4 – – 5.0 – – ( Zhang et al, 2022 ) MOF-fluorescent 0–2 × 10 4 0–2 × 10 4 0–2 × 10 4 65 390 92 ( Wang et al, 2022 ) Fluorescence – 25–1750 – – 9.5 – (Y. Wang et ...…”

Single-phase white light material and antibiotic detection of lanthanide metal–organic frameworks

“…[29][30][31][32][33] Due to its benefits of simplicity, high efficiency, fast response, and high selectivity, fluorescence sensing has attracted much attention. [34][35][36][37][38] Benefiting from the strong fluorescence emission and stable structure, the fluorescence detection performance of HNU-82 for antibiotics was also investigated. The fluorescence intensity of HNU-82 has a good quenching effect on nitrofurazone (NZF) and nitrofurantoin (NFT) in aqueous solution with the detection limits of NZF and NFT were 6.60 × 10 −7 mol L −1 and 4.62 × 10 −7 mol L −1 , respectively.…”