Heteroploid reticulate evolution and taxonomic status of an endemic species with bicentric geographical distribution

Nierbauer, Kai Uwe; Paule, Juraj; Zizka, Georg

doi:10.1093/aobpla/plx002

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…Owing to sustained autophagic stimulators, excessive autophagy leads to the depletion of organelles and key proteins and eventually leads to cell death [37][38][39] . Recently, several autophagy regulators, such as rapamycin, chloroquine, and hydroxychloroquine, have been widely used in cancer therapy [25,[40][41][42][43] . Thus, the development of novel autophagy regulators has presented remarkable potential in CRC treatment.…”

Section: Discussionmentioning

confidence: 99%

Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy

et al. 2021

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BackgroundColorectal cancer (CRC) is one of the most malignant cancer worldwide, and the limited e cacy of existing treatments is the leading cause of death in patients with CRC. Thus, novel drugs for CRC treatment are urgently needed. MethodsWe screened an FDA-approved small-molecule library upon HCT116 cells, and identi ed lomitapide as a novel CRC anticancer compound. Then we con rmed the activities of lomitapide on CRC cells by WST-1 assay, colony formation, and ow cytometry. RNA sequencing and GO analysis were used to investigate

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Section: Discussionmentioning

confidence: 99%

Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy

et al. 2021

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“…The discrimination between cryptic hybrids (Gaskin and Kazmer 2009) and purebred taxa has important implications for the delineation of conservation units (Allendorf et al 2001). The clarification of the taxonomic status of populations of endangered species is important for appropriate conservation measures (Smith and Waterway 2008;Nierbauer et al 2017). Although hybrid populations may have a certain conservation interest, protective laws often ignore hybrids.…”

Section: Introductionmentioning

confidence: 99%

Genetic status of the endangered plant species Gladiolus palustris in the western part of its distribution area

et al. 2019

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Many endangered plant species suffer from the effects of ongoing fragmentation of their populations leading to a loss of genetic diversity through genetic drift. In addition, populations of rare plants may also be affected by hybridization with other plant species. We studied the genetic population structure of populations of the endangered Gladiolus palustris in the western limit of its distribution area using AFLP markers. In addition, we clarified the taxonomic status of populations where hybridization with the closely related G. imbricatus was suspected based on morphology by sequencing the ITS region of the nuclear ribosomal DNA as well as two regions of the chloroplast DNA. Our analysis of the genetic population structure of G. palustris revealed a strong differentiation among geographical regions, which was much higher than the differentiation among populations within regions. Most populations retained a considerable amount of genetic variation. To counteract the future loss of genetic diversity through drift, we recommend using the largest populations per region as seed source to increase genetic diversity in genetic depauperate populations of the same region. Our genetic analyses indicated that some French populations of G. palustris are of hybrid origin. These hybridization events are likely to be ancient as these populations are very isolated and some parent taxa went regionally extinct. As these hybrid populations may elucidate post-glacial distribution patterns of related Gladiolus taxa, we advocate that they deserve the same conservation efforts as purebred ones.

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“…Reticulate evolution (e.g., horizontal gene transfer, introgression, and hybridization) has been considered an important driving force of angiosperm evolution with recombination of traits to accelerate the process of adaptation to new environments (Ellstrand & Schierenbeck, 2000;Davis & Wurdack, 2004;Seehausen, 2004;Vriesendorp & Bakker, 2005;Barton, 2010;Mallet et al, 2016;Nierbauer et al, 2017). Approximately 25% of the species of flowering plants, especially the species in rapidly radiating groups, are considered to involve in natural hybridization and introgression with other species (Mallet, 2005(Mallet, , 2007.…”

Section: Introductionmentioning

confidence: 99%

Testing reticulate evolution of fourVitisspecies from East Asia using restriction‐site associated DNA sequencing

Wen

Tian

et al. 2018

J of Sytematics Evolution

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Reticulate evolution is an important driving force of angiosperm evolution. It has been proposed as an important evolutionary process in Vitis L. subgenus Vitis. Events of natural hybridization and introgression of several taxa native to North America have been hypothesized and discussed. However, there is no convincing evidence of reticulate evolution reported for closely related Vitis taxa from East Asia. We aim to explore natural hybridization and introgression among four closely related Vitis taxa from East Asia (V. amurensis Ruprecht, V. romanetii Romanet du Caillaud, V. shenxiensis C. L. Li, and V. piasezkii Maximowicz) with the restriction‐site associated DNA sequencing technique. A total of 46 accessions, covering the potential morphological and geographic variation of each species, are sequenced. Our results show a complex evolutionary pattern of the four Vitis species. The phylogenetic inference suggests that V. amurensis is monophyletic, however, V. romanetii, V. shenxiensis, and V. piasezkii do not appear to be monophyletic. Significant signals of introgression in some accessions have been detected by population structure analyses. D‐statistics analysis and population structure analyses support the presence of introgression between V. shenxiensis/V. piasezkii and V. romanetii in sympatric populations, but a strong signal of admixture has not been recognized between distantly located populations. Our results provide strong evidence of reticulate evolution among V. romanetii, V. shenxiensis, and V. piasezkii.

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Heteroploid reticulate evolution and taxonomic status of an endemic species with bicentric geographical distribution

Cited by 5 publications

References 43 publications

Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy

Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy

Genetic status of the endangered plant species Gladiolus palustris in the western part of its distribution area

Testing reticulate evolution of fourVitisspecies from East Asia using restriction‐site associated DNA sequencing

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