Heterotopic Bone Formation in the Gall‐bladder

Js, Indyk; Ea, Shipton

doi:10.5694/j.1326-5377.1957.tb49413.x

Cited by 8 publications

(1 citation statement)

References 7 publications

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“…Heterotopic bone formation (or osseous metaplasia), a process whereby bone forms outside the skeletal system, has not been reported in the pediatric gallbladder. The English literature from 1966 to present contains rare reports of its occurrence in the adult gallbladder [11][12][13][14][15], and these reports are summarized in Table 1. Heterotopic bone formation can occur in soft tissue at sites of chronic injury.…”

Section: Discussionmentioning

confidence: 99%

Cholecystitis and Cholelithiasis Associated with an Intramural Fasciitis-Like Proliferation and Osseous Metaplasia

Rege

Vargas

2011

Pediatr Dev Pathol

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Fasciitis-like proliferations are said to be uncommon in the viscera; a fasciitis-like pattern of gallbladder injury may not be rare, but to our knowledge it has not been explicitly reported as such in any age group. Osseous metaplasia, or heterotopic bone, in the gallbladder is rare and has not to our knowledge been reported in a pediatric patient. We report a 7-year-old boy with sickle cell disease who presented with right upper quadrant abdominal pain. An ultrasonograph demonstrated a dilated common bile duct with sludge and stones. A cholecystectomy was performed. Grossly the gallbladder showed numerous pigmented choleliths, and histologically there was cholecystitis with a fasciitis-like fibrous proliferation containing scattered osteoclast-like giant cells and an area of osseous metaplasia. This report, describing a pattern that could be termed "cholecystitis ossificans," expands the histologic spectrum of chronic cholecystitis, a common disease with a poorly understood pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Cholecystitis and Cholelithiasis Associated with an Intramural Fasciitis-Like Proliferation and Osseous Metaplasia

Rege

Vargas

2011

Pediatr Dev Pathol

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Histological investigation of bone induction by demineralized allogeneic bone matrix: A natural biomaterial for osseous reconstruction

Vandersteenhoven

Spector

1983

J. Biomed. Mater. Res.

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The objective of the study was to delineate the histological sequence of events associated with bone formation induced in extraosseous sites by implants of demineralized allogeneic bone matrix (DABM) in order to provide a more complete basis for the clinical use of the natural biomaterial for osseous reconstruction. The rat was the experimental animal model. Implants were prepared by demineralization of diaphyseal cortical rat bone in 0.6N HCl for 18-24 h. A total of 104 specimens, 4 mm square, were implanted both subcutaneously and intramuscularly in 26 rats for periods of 3 days to 22 weeks. Histological evaluation revealed a sequence of events that at 3 days displayed an inflammatory response to surgical trauma and after 6 weeks exhibited the formation of a mature lamellar ossicle with central marrow which was maintained through 22 weeks. Resorption of the DABM, first evident at 1 week, was accompanied by the appearance of chondroblast in vascular canals and in crevices in the implant. Osteoblastic activity, initially seen at 2 weeks, appeared to be associated with capillary and blood vessel formation around the implant and within enlarged resorptive cavities within the specimens. Calcification occurred in the cartilaginous matrix and osteoid and within the implanted matrix. The osteoinductive process comprises (1) the inflammation/granulation/scar formation processes elicited by implantation of a material, (2) the resorptive response elicited by DABM, and (3) the process of induction of nonosseous mesenchymal cells to differentiate to chondroblasts and osteoblasts. The results of the present study support previous investigations demonstrating the bone-inducing property of DABM and provide further evidence for the potential value of this natural biomaterial for use in osseous reconstruction.

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Bony and cartilaginous tumours of the urinary bladder

Shu‐Chao

Pang

1958

J. Pathol.

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Heterotopic Bone Formation in the Gall‐bladder

Cited by 8 publications

References 7 publications

Cholecystitis and Cholelithiasis Associated with an Intramural Fasciitis-Like Proliferation and Osseous Metaplasia

Cholecystitis and Cholelithiasis Associated with an Intramural Fasciitis-Like Proliferation and Osseous Metaplasia

Histological investigation of bone induction by demineralized allogeneic bone matrix: A natural biomaterial for osseous reconstruction

Bony and cartilaginous tumours of the urinary bladder

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