Heterotopic ossification in a lymph node with metastatic follicular carcinoma of thyroid: A case report

Wasiljew, Bohdan K.; Apostol, James V.; Rao, M. Sambasiva

doi:10.1002/jso.2930170108

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…An interesting, although rare, characteristic of thyroid tumors is intratumoral heterotopic ossification 48 49 50 51 52 53 54 , which may suggest the presence of multipotent mesenchymal stem/stromal cells in thyroid tissue. Indeed, tumor-associated MSCs recently characterized in ovarian carcinoma and prostate cancer have similar phenotype and functionality as BM MSC but altered growth factor expression profile 55 56 .…”

Section: Discussionmentioning

confidence: 99%

Extracellular Superoxide Dismutase Expression in Papillary Thyroid Cancer Mesenchymal Stem/Stromal Cells Modulates Cancer Cell Growth and Migration

Parascandolo

Rappa

Cappello

et al. 2017

Sci Rep

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Tumor stroma-secreted growth factors, cytokines, and reactive oxygen species (ROS) influence tumor development from early stages to the metastasis phase. Previous studies have demonstrated downregulation of ROS-producing extracellular superoxide dismutase (SOD3) in thyroid cancer cell lines although according to recent data, the expression of SOD3 at physiological levels stimulates normal and cancer cell proliferation. Therefore, to analyze the expression of SOD3 in tumor stroma, we characterized stromal cells from the thyroid. We report mutually exclusive desmoplasia and inflammation in papillary and follicular thyroid cancers and the presence of multipotent mesenchymal stem/stromal cells (MSCs) in non-carcinogenic thyroids and papillary thyroid cancer (PTC). The phenotypic and differentiation characteristics of Thyroid MSCs and PTC MSCs were comparable with bone marrow MSCs. A molecular level analysis showed increased FIBROBLAST ACTIVATING PROTEIN, COLLAGEN 1 TYPE A1, TENASCIN, and SOD3 expression in PTC MSCs compared to Thyroid MSCs, suggesting the presence of MSCs with a fibrotic fingerprint in papillary thyroid cancer tumors and the autocrine-paracrine conversion of SOD3 expression, which was enhanced by cancer cells. Stromal SOD3 had a stimulatory effect on cancer cell growth and an inhibitory effect on cancer cell migration, thus indicating that SOD3 might be a novel player in thyroid tumor stroma.

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Section: Discussionmentioning

confidence: 99%

Extracellular Superoxide Dismutase Expression in Papillary Thyroid Cancer Mesenchymal Stem/Stromal Cells Modulates Cancer Cell Growth and Migration

Parascandolo

Rappa

Cappello

et al. 2017

Sci Rep

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Tumor Ossification

Connor

1983

Soft Tissue Ossification

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Heterotopic bone formation in rectal carcinoma

et al. 1992

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A case of heterotopic bone formation in a primary rectal adenocarcinoma was recently observed in a 54-year-old woman. This unusual finding was present both in the diagnostic biopsy and in the subsequently resected bowel. Pertinent gross and microscopic features are presented. This report represents the twelfth case in the literature of heterotopic bone formation in a primary rectal adenocarcinoma and the first such finding in a colonic biopsy from one of these malignancies. The average age of these patients was 56 years (range 32-72) and the male-to-female ratio was 5:7. The rectum is the most common site of ossification in the gastrointestinal tract. The exact mechanism of heterotopic ossification is unknown, but it is probably the result of metaplasia of fibroblasts. Adenocarcinoma has been associated with 12 of the 16 reported cases of rectal glandular tumors with heterotopic bone.

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Heterotopic ossification in a lymph node with metastatic follicular carcinoma of thyroid: A case report

Cited by 8 publications

References 12 publications

Extracellular Superoxide Dismutase Expression in Papillary Thyroid Cancer Mesenchymal Stem/Stromal Cells Modulates Cancer Cell Growth and Migration

Extracellular Superoxide Dismutase Expression in Papillary Thyroid Cancer Mesenchymal Stem/Stromal Cells Modulates Cancer Cell Growth and Migration

Tumor Ossification

Heterotopic bone formation in rectal carcinoma

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