Hexaconazole Induced Changes in the Histological Architecture of Male and Female Reproductive Systems in Rats

Kumar, Prabhat; Kanniappan, M.; Mathuram, L.N.; Selvasubra, S.; Manohar, B. Murali; Sriram, P.

doi:10.3923/rjpharm.2011.9.13

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, there is much concern that exposure to pesticides may cause reproductive toxicity through impairment of sperm motility, decreasing sperm counts, reducing fertilization ability and producing abnormal sperms [29]. Reproductive toxicity of PENZ and other triazole fungicides had been previously reported [1,16,30]. Therefore, abnormalities in sperm morphology in the current result could be attributed to a direct action of PENZ on testicular compartments, or due to an indirect manifestation through altered epididymal functions.…”

Section: Discussionmentioning

confidence: 68%

Ameliorative Effects of Sesame Seed Oil Against Penconazole-Induced Testicular Toxicity and Endocrine Disruption in Male Rats

Borai

Atef

El-Kashoury

et al. 2019

BJSTR

View full text Add to dashboard Cite

The current study investigated the protective effect of sesame seed oil (SSO) against testicular damage and endocrine disruption induced by the oral intoxication with penconazole (PENZ), a commonly used systemic triazole fungicide, in adult male Wistar rats. Subchronic oral exposure to two different doses of PENZ significantly reduced fertility indices, serum luteinizing hormone, follicle stimulating hormone, triiodothyronine and thyroxine levels, and by contrast a significant increase was recorded in serum estradiol and testosterone levels. Furthermore, PENZ significantly depleted testicular vitamins (A, C and E) level. On the other hand, administration of SSO prior to PENZ intoxication ameliorated most of the fertility indices and minimized PENZ-induced adverse effects on serum sexual, reproductive and thyroid hormones, compared to PENZ-treated animals. Histological data confirmed the biochemical findings. In conclusion, supplementation of SSO might be beneficial against the endocrine-disrupting potential and testicular toxicity induced by PENZ in adult male rats. abstract induced toxic effects on rat testes and endocrine disrupting potential and the probable protective effect of SSO supplementation.

show abstract

Section: Discussionmentioning

confidence: 68%