Hexane extractable chlorinated insecticides in human blood

Dale, William E.; Curley, August; Cueto, Cipriano

doi:10.1016/0024-3205(66)90186-x

Cited by 153 publications

(26 citation statements)

References 5 publications

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“…Dale, et al, 6 however, claimed that the six insecticides they routinely identified in the general population were so predominantly in plasma that serum or plasma values were satisfactory for toxicological studies. The practicality of their recommendation of doubling whole blood values to compare with serum values was confirmed during these studies, so long as a severe anemia did not co-exist.7 Since they demonstrated in vitro binding of insecticide, they postulated in vivo binding and suggest that n-hexane extract studies measured only the free or unbound moiety.…”

Section: Discussionmentioning

confidence: 99%

An epidemiologic application of the study of DDE levels in whole blood.

Davies¹,

Edmundson²,

Maceo³

et al. 1969

Am J Public Health Nations Health

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Section: Discussionmentioning

confidence: 99%

An epidemiologic application of the study of DDE levels in whole blood.

Davies¹,

Edmundson²,

Maceo³

et al. 1969

Am J Public Health Nations Health

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“…Extraction was modified from techniques described in Dale et al (1966) and U.S. EPA (1980). Briefly, serum (0.5 mL) was pipetted into a graduated stoppered centrifuge tube, 6 mL of hexane was added, and it was rotated in a slow-speed Roto-rac (National Institute of Occupational Health, Ahmedabad, India) for 2 hr.…”

Section: Methodsmentioning

confidence: 99%

Effect of endosulfan on male reproductive development.

Saiyed

Dewan

Bhatnagar

et al. 2003

Environ Health Perspect

196

119

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There is experimental evidence of adverse effects of endosulfan on the male reproductive system, but there are no human data. Therefore, we undertook a study to examine the relationship between environmental endosulfan exposure and reproductive development in male children and adolescents. The study population was composed of 117 male schoolchildren (10-19 years of age) of a village situated at the foothills of cashew plantations, where endosulfan had been aerially sprayed for more than 20 years, and 90 comparable controls with no such exposure history. The study parameters included recording of clinical history, physical examination, sexual maturity rating (SMR) according to Tanner stages, and estimation of serum levels of testosterone, luteinizing hormone (LH), follicle-stimulating hormone, and endosulfan residues (70 study and 47 control subjects). Mean +/- SE serum endosulfan levels in the study group (7.47 +/- 1.19 ppb) were significantly higher (p < 0.001) than in controls (1.37 +/- 0.40 ppb). Multiple regression analysis showed that SMR scoring for development of pubic hair, testes, penis, and serum testosterone level was positively related to age and negatively related to aerial exposure to endosulfan (AEE; p < 0.01). Serum LH levels were significantly positively related to AEE after controlling for age (p < 0.01). The prevalence of congenital abnormalities related to testicular descent (congenital hydrocele, undescended testis, and congenital inguinal hernia) among study and controls subjects was 5.1% and 1.1%, respectively, but the differences were statistically nonsignificant. Our study results suggest that endosulfan exposure in male children may delay sexual maturity and interfere with sex hormone synthesis. Our study is limited by small sample size and nonparticipation.

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“…Transfer of 5ml hexane extract was made to a 4 ml vial and eva p o ra ted with nitrogen steam. One microliter was ana l y zed by electron capture high resolution gas c h ro m a t o g raphy under standard conditions ( Dale et al, 1996). Chemical results we re re p o rted on the basis of volume (ng/ml or ppb).…”

Section: Chemical Analysesmentioning

confidence: 99%

Organochlorine exposure and breast cancer risk in Colombian women

et al. 1998

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An epidemiological study was performed in Santafé de Bogotá, Colombia, with a total of 306 women enrolled, including 153 incident BC cases and 153 age-matched controls. The objective of this study was to evaluate the association between BC risk and serum dichlorodiphenyl-dichloroethene (DDE) levels. Sociodemographic and reproductive data, diet, and past exposure to pesticides were obtained through a structured questionnaire. Chemical analysis of samples was performed by high resolution gas chromatography-ECD. Likelihood of developing BC by exposure to these substances was evaluated through odds ratios (OR) adjusted for: first-child breast-feeding, family BC history, body mass index (BMI), parity, and menopausal status. Data analysis was performed by conditional logistic regression techniques. Adjusted OR for exposure to serum DDE and BC suggests an increase risk of BC in the higher category of DDE exposure (OR = 1.95; CI 1.10-3.52). The test for trend was not statistically significant (p = 0.09). We confirm that serum DDE levels bear a positive association to risk of BC and could support the association between risk of BC and burden of DDE exposure.

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Hexane extractable chlorinated insecticides in human blood

Cited by 153 publications

References 5 publications

An epidemiologic application of the study of DDE levels in whole blood.

An epidemiologic application of the study of DDE levels in whole blood.

Effect of endosulfan on male reproductive development.

Organochlorine exposure and breast cancer risk in Colombian women

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