Hibernoma cervical e lipoblastomatose

Abstract

Lipoblastoma and lipoblastomatosis are rare benign soft-tissue tumoral lesions resembling fetal adipose tissue. A total of 16 cases of lipoblastoma of the neck were reported in the literature, and only 3 were described in the posterior side of the neck. Hibernoma is a rare benign adipose tumor composed of brown fat cells and only about ten cases occurring in the cervical area have been reported. We reported two rare cases of adipose tissue tumors. The first case was a male infant aged 12 months who had a cervical mass on the posterior side of the neck. He underwent a complete resection of the lesion and the pathologic study revealed lipoblastomatosis. The second case was a 36-year-old man with an anterior cervical mass, which moved with swallowing. A resection was made and the histological analysis showed hibernoma.

Lipoblastoma: a clinicopathologic review of 23 cases from a major tertiary care center plus detailed review of literature

“…Grossly, these are soft, lobulated and yellow, white or tan in color. Fat, myxoid nodules or cystic spaces separated by fine, white, fibrous septa are seen on cut surface [ 9 , 14 – 17 , 19 , 21 , 22 , 24 , 27 , 29 ]. All tumors in our study were encapsulated, soft and showed fibrous septations.…”

“…In one study [ 16 ], lobules bordered by septa were seen in 44%, prominent blood vessels in 76% and myxoid foci in 52% cases. Mitoses are rare, abnormal mitoses are never seen [ 9 , 16 , 17 , 19 – 21 , 23 , 29 ]. On IHC, adipocytes are positive for CD34 and S100 protein, while primitive cells are positive for Desmin [ 9 ].…”

“…Most common locations include extremities and trunk [ 10 – 15 ]. Lipoblastomas have been reported in head and neck [ 12 , 13 , 16 – 21 ], mediastinum, axilla, labia, vulva, abdomen, retroperitoneum, groin, inguinoscrotal, and gluteal region [ 14 – 16 , 22 – 27 ]. Lipoblastomatosis is reserved for lesions which demonstrate infiltrative growth [ 2 , 8 , 11 , 16 , 20 , 21 ].…”

Rapidly growing facial tumor in a 5-year-old girl

“…However, these characteristics can be ambiguous and overlap with other lesions such as simple lipoma, hibernoma, and, importantly, malignant lesions such as myxoid liposarcoma. [ 1 4 8 15 29 ]…”

“…[ 2 8 ] Hibernoma is also characteristic of adults, is very rare in children under 18 years of age, and is histologically defined as a tumor of embryonic brown fat, showing characteristic eosinophilia; also, it usually has a lobular pattern and granular cytoplasm not present in the white fat of lipoblastoma. [ 2 11 15 ] Regardless, both lesions are benign, and the treatment is complete excision. [ 2 8 11 15 ]…”