Hidradenitis suppurativa (HS) and Down syndrome (DS): Increased prevalence and a younger age of hidradenitis symptom onset

Denny, George; Anadkat, Milan J.

doi:10.1016/j.jaad.2016.04.045

Cited by 27 publications

(52 citation statements)

References 5 publications

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“…In our sample series, the mean age at diagnosis (21.1 vs. 31.8 years; p = 0.01), as well as the age of onset (14.3 ± 3.6 vs. 23.4 ± 12.31 years; p = 0.029), was significantly lower in patients with HS and DS compared to those with HS only. This finding is comparable with that of other authors [12] who detected a younger age in patients with HS and DS compared to those without DS (17.9 vs. 33.9 years; p < 0.001). In line with previous studies [10, 12], our 9 patients with HS and DS had a mild severity of the disease (Hurley stage I in 7 cases and Hurley stage II in 2 cases) and therefore they had been treated with topical corticosteroids and antibiotics, achieving a good control of the disease.…”

Section: Discussionsupporting

confidence: 91%

“…This finding is comparable with that of other authors [12] who detected a younger age in patients with HS and DS compared to those without DS (17.9 vs. 33.9 years; p < 0.001). In line with previous studies [10, 12], our 9 patients with HS and DS had a mild severity of the disease (Hurley stage I in 7 cases and Hurley stage II in 2 cases) and therefore they had been treated with topical corticosteroids and antibiotics, achieving a good control of the disease. No significant differences concerning sex, BMI, and comorbidities were found between patients with HS and DS compared to patients with HS only (Table 2).…”

Section: Discussionsupporting

confidence: 91%

“…A syndromic condition including both HS and DS, and belonging to group 1, has been previously described, but only in a few studies [10-16]. In a retrospective study, Denny and Anadkat [12] found that 16 of 667 (2.4%) patients with HS were concomitantly affected by DS, showing that the prevalence of DS was about 29 times higher in HS patients compared to the general population. In the present study, we evaluated all patients with HS examined in a multicenter university setting and found that the prevalence of DS in HS patients was 3.5% (9/257 patients).…”

Section: Discussionmentioning

confidence: 99%

“…DS is the most common chromosomal disorder, with an estimated prevalence of 8.27 people per 10,000 population (90% uncertainty interval: 6.14–10.62) [12]. The Down phenotype includes a wide range of congenital heart defects, endocrinological and neurological abnormalities, as well as a variety of dermatological disorders including alopecia areata and acne [13].…”

Section: Introductionmentioning

confidence: 99%

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Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

Giovanardi¹,

Chiricozzi

Bianchi

et al. 2018

Dermatology

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Background/Aims: The association between hidradenitis suppurativa (HS) and multiple comorbidities has been widely investigated but data about the coexistence of Down syndrome (DS) are scarce. We sought to evaluate the prevalence of DS among a population of HS patients and assess their clinical features. Methods: We collected demographic and clinical data of patients affected with HS referred to three Italian outpatient dermatology clinics. Results: A total of 257 HS patients were enrolled, 62% females and 38% males (mean age [±SD]: 23.3 ± 10.7 years); 9 of the 257 patients (3.5%), 7 females and 2 males, had concomitant HS and DS. The patients with DS and HS had a significantly earlier age of onset (mean age: 14.3 ± 3.6 vs. 23.4 ± 12.31 years; p = 0.029), a significantly younger age at diagnosis (mean age: 21.1 ± 11.1 vs. 31.8 ± 13.5 years; p = 0.015), and were significantly younger (mean age: 23.3 ± 10.7 vs. 34.6 ± 13.07 years; p = 0.005). No significant differences about other clinical data were found between the two groups. Conclusion: The prevalence of DS in HS patients corresponds to a not negligible 3.5% of cases, who experienced an onset of HS at a younger age compared to patients with HS only.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

Giovanardi¹,

Chiricozzi

Bianchi

et al. 2018

Dermatology

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“…We noticed a higher prevalence of Down syndrome in our cohort (6.5%) compared to the study done by Denny et al . in the US (2.4%) . The HS patients with Down syndrome described by Denny et al .…”

Section: Discussionmentioning

confidence: 98%

The clinical, biochemical, and ultrasonographic characteristics of patients with hidradenitis suppurativa in Northern Peninsular Malaysia: a multicenter study

et al. 2018

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Importance of a multi-tiered treatment approach for intellectually and developmentally disabled patients with hidradenitis suppurativa

et al. 2023

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Hidradenitis suppurativa (HS) and Down syndrome (DS): Increased prevalence and a younger age of hidradenitis symptom onset

Cited by 27 publications

References 5 publications

Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

The clinical, biochemical, and ultrasonographic characteristics of patients with hidradenitis suppurativa in Northern Peninsular Malaysia: a multicenter study

Importance of a multi-tiered treatment approach for intellectually and developmentally disabled patients with hidradenitis suppurativa

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