Hierarchical Alteration of Brain Structural and Functional Networks in Female Migraine Sufferers

Liu, Jixin; Zhao, Ling; Li, Guoying; Xiong, Shiwei; Nan, Jiaofen; Li, Jing; Yuan, Kai; Deneen, Karen M. von; Liang, Fanrong; Qin, Wei; Tian, Jie

doi:10.1371/journal.pone.0051250

Cited by 107 publications

(107 citation statements)

References 58 publications

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“…These findings are consistent with the current view of VM as a migraine subtype clinically characterized by vestibular symptoms and correlated with interictal dysfunctional central vestibulo-thalamocortical processing [1]. Both structural and functional thalamic abnormalities are documented in patients with migraine [2].…”

Section: Headache Disorders Thalamic Function and Vestibular Migrainesupporting

confidence: 90%

Thalamic Function and Vestibular Migraine

Millichap¹

2014

Pediatr Neurol Briefs

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Section: Headache Disorders Thalamic Function and Vestibular Migrainesupporting

confidence: 90%

Thalamic Function and Vestibular Migraine

Millichap¹

2014

Pediatr Neurol Briefs

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“…The compelling evidence that several functional connectivity networks are altered in CH (2,3) suggests that the underlying anatomical connectivity is also abnormal. This is in agreement with several studies suggesting that chronic pain causes functional and anatomical network reorganization (20).…”

supporting

confidence: 94%

Exploring cerebral networks in cluster headache: Insights and perspectives

et al. 2013

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In the last several years, neuroimaging studies have greatly increased our knowledge of cluster headache (CH) pathophysiology (1). The main neuroimaging techniques used to investigate functional and structural changes in CH include positron-emission tomography (PET) (2,3), functional magnetic resonance imaging (fMRI) (4-6), structural magnetic resonance imaging (sMRI) (7-9) and diffusion tensor imaging (DTI) (9-11).PET and fMRI indirectly measure the neural activity that assesses, respectively, regional glucose uptake and blood oxygen level-dependent (BOLD) signal during the execution of a task or in resting state condition (12). Advances in fMRI data processing, such as the use of independent component analyses and correlation analyses among signals detected in defined brain regions, have allowed researchers to assess the temporal dependency of neural activation patterns of spatially separated brain regions and therefore to investigate functional connectivity. While fMRI can assess functional connectivity, structural connectivity can be assessed with DTI (13). This imaging technique measures local fractional anisotropy (direction of water molecules diffusion) and enables mapping of white matter tracts. The imaging technique sMRI investigates structural brain abnormalities by assessing macroscopic volumetric changes of gray matter tissue, using methods such as voxel-based morphometry (VBM) (14) and the measure of cortical thickness (15).Seminal PET studies initially suggested that the ipsilateral posterior hypothalamic area played a key role as the cluster headache generator (generator of pain attacks) (2,3). This result was supported by an sMRI study that showed volumetric abnormality of this structure (8). However, long-term results on the efficacy of deep brain stimulation (DBS) in CH (16) indicated that the hypothalamus is not the trigger of CH attacks but might play a role in the dynamic interactions between not-yet known cortical and subcortical areas and the hypothalamo-trigeminal pathway (17).Other brain regions in the so-called pain matrix could play a role in CH pathophysiology (18). Indeed, during CH attacks, a PET study showed the involvement of brain regions related to pain processing, such as the anterior and posterior cingulate cortices and the insular and orbitofrontal cortices (2). More recently, a DTI study has shown microstructural changes in similar brain areas belonging to the pain network (10). Accordingly, resting state fMRI studies reported abnormal functional connectivity between the hypothalamus and pain-related regions during CH attacks (4). Interestingly, diffuse abnormal functional connectivity was also reported in areas beyond the pain matrix network during (4) and outside (5) the attack period.To understand anatomic pathways employed by DBS to improve CH and facilitate a more precise patient-specific targeting of DBS, Clelland and colleagues used probabilistic DTI to map the common connectivity of DBS-targeted regions (19).They showed that DBS targets project to the ipsilateral hyp...

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“…This measure quantifies the ability of information transfer from a given node to the other nodes in the cortical network. 22 The betweenness centrality of a brain node denotes the number of shortest paths between all possible pairs for the rest of the nodes through the given node, 24 which is computed in…”

Section: Nodal Centralitymentioning

confidence: 99%

Topological Alterations of the Intrinsic Brain Network in Patients with Functional Dyspepsia

Nan

Zhang

Zhu

et al. 2015

J Neurogastroenterol Motil

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Background/AimsPrevious studies reported that integrated information in the brain ultimately determines the subjective experience of patients with chronic pain, but how the information is integrated in the brain connectome of functional dyspepsia (FD) patients remains largely unclear. The study aimed to quantify the topological changes of the brain network in FD patients. MethodsSmall-world properties, network efficiency and nodal centrality were utilized to measure the changes in topological architecture in 25 FD patients and 25 healthy controls based on functional magnetic resonance imaging. Pearson's correlation assessed the relationship of each topological property with clinical symptoms. ResultsFD patients showed an increase of clustering coefficients and local efficiency relative to controls from the perspective of a whole network as well as elevated nodal centrality in the right orbital part of the inferior frontal gyrus, left anterior cingulate gyrus and left hippocampus, and decreased nodal centrality in the right posterior cingulate gyrus, left cuneus, right putamen, left middle occipital gyrus and right inferior occipital gyrus. Moreover, the centrality in the anterior cingulate gyrus was significantly associated with symptom severity and duration in FD patients. Nevertheless, the inclusion of anxiety and depression scores as covariates erased the group differences in nodal centralities in the orbital part of the inferior frontal gyrus and hippocampus. ConclusionsThe results suggest topological disruption of the functional brain networks in FD patients, presumably in response to disturbances of sensory information integrated with emotion, memory, pain modulation, and selective attention in patients. (J Neurogastroenterol Motil 2016;22:118-128)

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Hierarchical Alteration of Brain Structural and Functional Networks in Female Migraine Sufferers

Cited by 107 publications

References 58 publications

Thalamic Function and Vestibular Migraine

Thalamic Function and Vestibular Migraine

Exploring cerebral networks in cluster headache: Insights and perspectives

Topological Alterations of the Intrinsic Brain Network in Patients with Functional Dyspepsia

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