Hierarchical and heterogeneous hydrogel system as a promising strategy for diversified interfacial tissue regeneration

Zhang, Liwen; Fu, Lei; Zhang, Xin; Chen, Linxin; Cai, Qing; Yang, Xiaoping

doi:10.1039/d0bm01595d

Cited by 26 publications

(18 citation statements)

References 217 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Briefly, GelMA has suffered from its incapacity to construct sophisticated biomimetic structures. This is because the homogeneous architecture of the GelMA scaffolds fails to mimic the heterogeneous structure of natural bone, thus hindering its potential to treat critical-size bone defects (Zhang et al, 2021). In this study, to address the drawbacks associated with traditional bulk biomaterials in bone regeneration, a hydrogel scaffold with a biomimetic heterogeneous structure was designed to recreate the osteogenic activity of bone matrix and the angiogenic activity of periosteum.…”

Section: Introductionmentioning

confidence: 99%

A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects

Wang

Mao

Cai

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The regeneration of critical-size bone defects on long bones has remained a significant challenge because of the complex anatomical structure and vascular network. In such circumstances, current biomaterial forms with homogeneous structure and function can hardly satisfy the need for both osteogenesis and angiogenesis. In the current study, a heterogeneous biomimetic structured scaffold was constructed with the help of a 3D printed mold to simultaneously mimic the outer/inner periosteum and intermediate bone matrix of a natural long bone. Because of the reinforcement via modified mesoporous bioactive glass nanoparticles (MBGNs), enhanced structural stability and adequate osteogenic capacity could be achieved for the intermediate layer of this scaffold. Conversely, GelMA incorporated with VEGF-loaded liposome exhibiting controlled release of the angiogenic factor was applied to the inner and outer layers of the scaffold. The resulting heterogeneous structured scaffold was shown to successfully guide bone regeneration and restoration of the natural bone anatomic structure, rendering it a promising candidate for future orthopedic clinical studies.

show abstract

Section: Introductionmentioning

confidence: 99%

A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects

Wang

Mao

Cai

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…The water content of the pure PAA hydrogel without ultralong HAP nanowires is 68 wt.%, and the water contents of the HFMOS hydrogel samples obtained at various molding pressures are similar (~ 65 wt.%-68.5 wt.%) (Fig. 2(b)), which are comparable to those of natural biological tissues (for example, cartilage, ~ 70 wt.%) [35]. When the HFMOS hydrogel is completely dried in air and rehydrated in water until reaching the equilibrium, the water recovery percentages of the HFMOS hydrogel are 85%-90% of its original value (Fig.…”

Section: Microstructure Of the Hfmos Hydrogelmentioning

confidence: 67%

Bioinspired flexible, high-strength, and versatile hydrogel with the fiberboard-and-mortar hierarchically ordered structure

Zhu

2021

Nano Res.

View full text Add to dashboard Cite

The synthetic hydrogels with high water contents are promising for various applications, however, they usually exhibit low mechanical properties. In this work, inspired by the natural biological soft tissues, whose hierarchically ordered fibrous structures result in high strength and good flexibility, a flexible, high-strength, and versatile hydrogel with the fiberboard-and-mortar hierarchically ordered structure (HFMOS) is developed based on ultralong hydroxyapatite (HAP) nanowires and polyacrylic acid (PAA). The as-prepared HFMOS hydrogel has a high water content (~ 70 wt.%), dense structure, and excellent mechanical properties, and these properties are similar to those of the human cartilage and are superior to many hydrogels reported in the literature. The excellent mechanical properties of the HFMOS hydrogel originate from the combination of the fiberboard-and-mortar hierarchically ordered structure, reinforcement of ultralong HAP nanowires, strong interfacial strength, and multiple energy dissipation pathways. Moreover, thanks to the controllable components and injection procedure, the HFMOS hydrogel with a Janus structure is prepared for particular applications. The HFMOS hydrogel possesses abundant ordered water channels, and can be used for loading, release, and directed delivery of various functional substances. Thus, the as-prepared flexible, high-strength, and versatile HFMOS hydrogel possesses a great potential for various applications such as water purification, pollution treatment, biomedicine, nanofluidic devices, and high-performance structural materials.

show abstract

“…456,457 Gradient hydrogels enable to integrate variable properties into a single gel material leading to many possible applications including tissue engineering and cell culturing. 458,459 Different stimuli can be employed to generate hydrogels with intrinsic heterogeneous structures over a broad length scale. 457 Photo-patterned hydrogels are the most common heterogeneous gels with a tunable gradients in mechanical and photophysical properties (discussed in Section 3(iii)).…”

Section: Future Perspectivementioning

confidence: 99%

Stimuli responsive dynamic transformations in supramolecular gels

2021

View full text Add to dashboard Cite

show abstract

Hierarchical and heterogeneous hydrogel system as a promising strategy for diversified interfacial tissue regeneration

Abstract: A state-of-the-art review on the design and preparation of hierarchical and heterogeneous hydrogel systems for interfacial tissue regeneration.

Cited by 26 publications

References 217 publications

A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects

A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects

Bioinspired flexible, high-strength, and versatile hydrogel with the fiberboard-and-mortar hierarchically ordered structure

Stimuli responsive dynamic transformations in supramolecular gels

Contact Info

Product

Resources

About