Hierarchical Composite Self‐Sorted Supramolecular Gel Noodles

Marshall, Libby J.; Wallace, Matthew; Mahmoudi, Najet; Ciccone, Giuseppe; Wilson, Claire; Vassalli, Massimo; Adams, Dave J.

doi:10.1002/adma.202211277

Cited by 8 publications

(12 citation statements)

References 39 publications

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“…Hence, at a high pH, we have a self-sorted micellar system with two co-existing populations. We highlight that this is not always the case; we have recently shown that two structurally dissimilar functionalized dipeptides form mixed micelles at a high pH . We also note that due to operational issues, the cryo-TEM data were collected around 1 year after sample formation, implying that there is no kinetic trapping occurring.…”

Section: Resultsmentioning

confidence: 90%

“…We highlight that this is not always the case; we have recently shown that two structurally dissimilar functionalized dipeptides form mixed micelles at a high pH. 29 We also note that due to operational issues, the cryo-TEM data were collected around 1 year after sample formation, implying that there is no kinetic trapping occurring. An interesting case was observed for one case where we were able to observe the formation of nanotubes from (L,D)-2NapFF.…”

Section: ■ Results and Discussionmentioning

confidence: 97%

“…30,31 It is worth noting that we have worked with other examples where co-assembly occurs 20,29 �in these cases, the molecules are very different, but the micellar structures are a wormlike micelle and a spherical micelle. Since very different molecules can co-assemble at a high pH 20,29 and (in some cases also at a low pH 20 ), the self-sorting here does not seem to be driven simply by the small differences in molecular structure, but rather by the fact that both of these structures form robust nanotubes at a high pH. However, further work is needed with other systems to understand this.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Self-Sorting in Diastereomeric Mixtures of Functionalized Dipeptides

Guan

McAulay

et al. 2023

Biomacromolecules

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Self-sorting in functionalized dipeptide systems can be driven by the chirality of a single amino acid, both at a high pH in the micellar state and at a low pH in the gel state. The structures formed are affected to some degree by the relative concentrations of each component showing the complexity of such an approach. The structures underpinning the gel network are predefined by the micellar structures at a high pH. Here, we describe the systems prepared from two dipeptide-based gelators that differ only by the chirality of one of the amino acids. We provide firm evidence for self-sorting in the micellar and gel phases using small-angle neutron scattering and cryo-transmission electron microscopy (cryo-TEM), showing that complete self-sorting occurs across a range of relative concentrations.

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Section: Resultsmentioning

confidence: 90%

Section: ■ Results and Discussionmentioning

confidence: 97%

Section: ■ Results and Discussionmentioning

confidence: 99%

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Self-Sorting in Diastereomeric Mixtures of Functionalized Dipeptides

Guan

McAulay

et al. 2023

Biomacromolecules

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“…Among supramolecular assemblies of small molecules, peptide assemblies have received considerable research attention over the last few decades. − Therefore, it is not surprising that peptide assemblies formed by EISA have become the most explored molecular platform for various applications since the demonstration of the EISA of small molecules . The first example of EISA in a living organism is the use of EISA of peptides to inhibit the growth of bacteria .…”

Section: Intracellular Peptide Assemblies Formed By Eisamentioning

confidence: 99%

Enzyme-Instructed Intracellular Peptide Assemblies

Liu,

Guo,

Qiao

et al. 2023

Acc. Chem. Res.

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Higher-order or supramolecular protein assemblies, usually regulated by enzymatic reactions, are ubiquitous and essential for cellular functions. This evolutionary fact has provided a rigorous scientific foundation, as well as an inspiring blueprint, for exploring supramolecular assemblies of man-made molecules that are responsive to biological cues as a novel class of therapeutics for biomedicine. Among the emerging man-made supramolecular structures, peptide assemblies, formed by enzyme reactions or other stimuli, have received most of the research attention and advanced most rapidly. In this Account, we will review works that apply enzyme-instructed self-assembly (EISA) to generate intracellular peptide assemblies for developing a new kind of biomedicine, especially in the field of novel cancer nanomedicines and modulating cell morphogenesis. As a versatile and cell-compatible approach, EISA can generate nondiffusive peptide assemblies locally; thus, it provides a unique approach to target subcellular organelles with exceptional cell selectivity. We have arranged this Account in the following way: after introducing the concept, simplicity, and uniqueness of EISA, we discuss the EISA-formed intracellular peptide assemblies, including artificial filaments, in the cell cytosol. Then, we describe the representative examples targeting subcellular organelles, such as mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and the nucleus, by enzyme-instructed intracellular peptide assemblies for potential cancer therapeutics. After that, we highlight the recent exploration of the transcytosis of peptide assemblies for controlling cell morphogenesis. Finally, we provide a brief outlook of enzyme-instructed intracellular peptide assemblies. This Account aims to illustrate the promise of EISA-generated intracellular peptide assemblies in understanding diseases, controlling cell behaviors, and developing new therapeutics from a class of less explored molecular entities, which are substrates of enzymes and become building blocks of self-assembly after the enzymatic reactions.

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“…[33] In this work, we aim to examine the effect of varying micellar agreements on calcium-bridged cross-linked gel, also known as "gel noodles." [34][35][36]…”

Section: Introductionmentioning

confidence: 99%

Fine‐Tuning Supramolecular Assemblies by Controlling Micellar Aggregates

Ghosh

Marshall

Ciccone

et al. 2023

Macro Materials & Eng

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Supramolecular assembly can be used to fabricate complex functional materials by organizing simple building blocks. However, it is difficult to control the hierarchical assembly across multiple length scales. The correlation of a supramolecular gel network and a pre‐gelling aggregate will help to understand how a molecular‐level assembly is translated into a higher order. Here, a functional dipeptide 2NapFF is used that can assemble in different micellar structures at high pH by varying the counterion. Replacing the counterions with a divalent calcium salt results in a cross‐linked gel network, or an interesting analog “gel noodles.” The physical properties of the gel noodles can be varied by choosing specific micellar assemblies as the pre‐gel. The mechanical rigidity of the gel networks is compared by nanoindentation and tensile testing, and the pattern to the structures of the micelles observed by small‐angle X‐ray scattering is correlated. The supramolecular assembly can be fine‐tuned by using different micelles as the pre‐gel without affecting the inherent gel‐state properties.

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Hierarchical Composite Self‐Sorted Supramolecular Gel Noodles

Cited by 8 publications

References 39 publications

Self-Sorting in Diastereomeric Mixtures of Functionalized Dipeptides

Self-Sorting in Diastereomeric Mixtures of Functionalized Dipeptides

Enzyme-Instructed Intracellular Peptide Assemblies

Fine‐Tuning Supramolecular Assemblies by Controlling Micellar Aggregates

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