1999
DOI: 10.1046/j.1365-2958.1999.01422.x
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Hierarchical gene regulatory systems arising from fortuitous gene associations: controlling quorum sensing by the opine regulon in Agrobacterium

Abstract: Conjugation of the Agrobacterium Ti plasmid pTiC58 is regulated by a hierarchy involving induction by the opines agrocinopines A and B and a quorum‐sensing system. Regulation by the opines is mediated by the repressor AccR, while quorum sensing is effected by the transcriptional activator TraR and its ligand, the acyl‐homoserine lactone signal molecule Agrobacterium autoinducer (AAI). These last two elements combine to activate expression of the tra system at high population densities. Sequence analysis indica… Show more

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Cited by 89 publications
(132 citation statements)
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“…The transfer of wild-type pTiC58 (Fig. 1) requires induction by the sugar phosphodiester opines agrocinopines A and B (1, 9) and also activation of TraR by AAI (35). Since TraR and AAI comprise the two components of a typical quorum-sensing system, we determined whether the frequency of transfer of wild-type pTiC58 is influenced by the size of the donor population.…”
Section: Resultsmentioning
confidence: 99%
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“…The transfer of wild-type pTiC58 (Fig. 1) requires induction by the sugar phosphodiester opines agrocinopines A and B (1, 9) and also activation of TraR by AAI (35). Since TraR and AAI comprise the two components of a typical quorum-sensing system, we determined whether the frequency of transfer of wild-type pTiC58 is influenced by the size of the donor population.…”
Section: Resultsmentioning
confidence: 99%
“…The quorum-sensing system of pTiC58 is itself controlled by the opine regulon (35). In the absence of the conjugal opine, expression of traR is strongly repressed.…”
Section: Resultsmentioning
confidence: 99%
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