Hierarchical supramolecular hydrogels: self-assembly by peptides and photo-controlled release via host–guest interaction

Abstract

A hierarchical supramolecular hydrogel was self-assembled from a Fmoc-RGDS tetrapeptide and showed photo-controlled release directed by host-guest interaction. Multiple payloads, including vesicles, were successively released from a single peptide hydrogel.

Arylazopyrazole Photoswitches in Aqueous Solution: Substituent Effects, Photophysical Properties, and Host–Guest Chemistry

“…Later, we were able to show that AAPs could be additionally used in CD‐based supramolecular systems, which exhibited similar light‐responsive interactions with β‐CD to those reported for azobenzenes . In recent publications, we have reported several improved light‐responsive systems with the new AAP/CD motif to enable better photocontrol, through which photoswitching of azobenzene restricted the function of the supramolecular system, such as particle assemblies, hydrogels, or DNA compaction …”

“…[36] In recent publications,w eh ave reported severali mproved light-responsive systemsw ith the new AAP/CDm otif to enable better photocontrol, through which photoswitching of azobenzene restricted the function of the supramolecular system, such as particle assemblies, hydrogels, or DNA compaction. [37][38][39][40][41][42] Similar to azobenzenes, it is expectedt hat for AAPs the properties of the photoswitch will be strongly dependent on the substitution pattern of the molecule. Af irst study on varying the heterocycle wasr eported by Fuchter and co-workersi n 2017 to support this expectation.…”

Light‐Responsive Arylazopyrazole Gelators: From Organic to Aqueous Media and from Supramolecular to Dynamic Covalent Chemistry

“…Thiso bservation indicates that these organogels can be appliedf or light-responsive patterning by using ap hotomask, similart ow hat has been recently described by Venkataramania nd co-workers for tripodalA AP derivatives in the solid state. [64] Rheological measurements confirmed the viscoelasticity and the photoresponseo ft he organogelp repared in toluene. Two different concentrations of the organogel, 10 and 15 mg mL À1 , were tested by frequency sweep measurements ( Figure 4A).…”

“…[62,63] Recently,a lso al ight-responsive peptideh ydrogel featuring hostguest interactions betweenA AP peptides and cyclodextrin vesicles was introduced by our group. [64] Ap articularly versatile class of supramolecular polymers assembles from tripodal" core-arm" small molecules. In most cases,t hese supramolecular polymers are based on cyclohexane, [65,66] or benzene [67,68] cores.…”

Surface‐Selective Grafting of Crosslinking Layers on Hydrogel Surfaces via Two Different Mechanisms of Photopolymerization for Site‐Controllable Release

“…Substance release of the modified hydrogel evidently declined with increasing photografting time. RhB release was close to 90% in 5 h without photografting but declined to 20% after a photografting of 4 min and a cationic photopolymerization of 60 s. These results indicate that site‐controlled substance release can be realized by controlling photografting and photo‐crosslinking time. The epoxide group residue can act as the reaction site to introduce other target groups.…”