2013
DOI: 10.1182/blood-2012-09-457283
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Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma

Abstract: Key Points• Analysis of coding genomes of FL tumor subpopulations reveals striking clonal diversity at diagnosis and progression.• Within a hierarchy of somatic evolution of FL coding genomes, many recurrent mutations are subclonal at diagnosis.Follicular lymphoma (FL) is currently incurable using conventional chemotherapy or immunotherapy regimes, compelling new strategies. Advances in high-throughput sequencing technologies that can reveal oncogenic pathways have stimulated interest in tailoring therapies to… Show more

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Cited by 283 publications
(264 citation statements)
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“…S8B). This is in line with our prior observations that allelic frequencies within the bulk tumor are poorly predictive of clonal origin (12). The average mutational burden of the EIP was 221 mutations (range, 59-447 mutations).…”
Section: Frequent Cooccurring Mutations Of Chromatin-modifying Genes supporting
confidence: 78%
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“…S8B). This is in line with our prior observations that allelic frequencies within the bulk tumor are poorly predictive of clonal origin (12). The average mutational burden of the EIP was 221 mutations (range, 59-447 mutations).…”
Section: Frequent Cooccurring Mutations Of Chromatin-modifying Genes supporting
confidence: 78%
“…We performed exome sequencing on 65 tumors from 28 patients. Ten tumors from eight patients, including two patients with paired diagnosis and relapse, have been described previously (12). For the remaining 55 tumors from 20 patients, 11 patients had paired diagnosis and a single relapse, six patients had paired diagnosis and two relapses, and three patients had paired diagnosis and three relapses.…”
Section: Methodsmentioning
confidence: 99%
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