2019
DOI: 10.1016/j.prp.2018.12.022
|View full text |Cite
|
Sign up to set email alerts
|

HIF1A and VEGF regulate each other by competing endogenous RNA mechanism and involve in the pathogenesis of peritoneal fibrosis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
20
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
7
2
1

Relationship

0
10

Authors

Journals

citations
Cited by 37 publications
(22 citation statements)
references
References 32 publications
0
20
0
Order By: Relevance
“…Under a hypoxia state, HIF-1α accumulates, dimerizes with a HIF-1β, translocates to the nucleus, and transcriptionally activates its downstream genes (Kaelin and Ratcliffe, 2008). Previous studies have shown that HIF1-α-VEGFA pathway is involved in various organ fibrosis (Barratt et al, 2017;Elzamly et al, 2017;Li et al, 2019). In this study, we found that Nestin can interact with HIF-1α and increase its protein level.…”
Section: Discussionmentioning
confidence: 48%
“…Under a hypoxia state, HIF-1α accumulates, dimerizes with a HIF-1β, translocates to the nucleus, and transcriptionally activates its downstream genes (Kaelin and Ratcliffe, 2008). Previous studies have shown that HIF1-α-VEGFA pathway is involved in various organ fibrosis (Barratt et al, 2017;Elzamly et al, 2017;Li et al, 2019). In this study, we found that Nestin can interact with HIF-1α and increase its protein level.…”
Section: Discussionmentioning
confidence: 48%
“…On the one hand, HIF 1α expression in transplant biopsies is associated with early recovery of graft function (129). On the other hand, both HIF1α and VEGF increased in the peritoneal effluent of PD patients with ultrafiltration failure and might be involved in the pathogenesis of peritoneal fibrosis (130). Future trials of HIF enhancing medications, such as PHD2 inhibitors, are needed to investigate whether, in addition to their role in the treatment of renal anemia, they also have preventive effects against hypoxia related tissue injury, inflammation as well as senolytic effects.…”
Section: Therapeutic Implicationsmentioning
confidence: 99%
“…4). MiR-17-5p has been reported to regulate peritoneal brosis through the positive feedback loop of HIF1A and VEGF 25 . MiR-155-5p has been implicated as a multifunctional molecule that includes SHIP1, HBP1, SOCS1, BCL6, CARHSP1, and MAP3K10, which are linked to atherosclerotic in ammatory processes and are regulated in coronary artery disease 26 .…”
Section: Discussionmentioning
confidence: 99%