HIFU: Effects and Clinical Effectiveness of Non-surgical Therapy for Uterine Fibroids

Chang, Ikjin; Hwang, Kyoung Jin; Choi, Ho Jin; Yoon, Hyo Jin; Lee, Eung Seok; Choi, Sun Young

doi:10.6118/jmm.2016.22.2.59

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…High-intensity focused US has increasingly been used for treatment of uterine fibroids worldwide because of its excellent therapeutic efficacy in producing symptomatic relief. 26,27 It has been revealed that HIFU has a therapeutic effect on uterine fibroids mainly by causing coagulation necrosis of targeted tissue, which was presented as a nonenhancement characteristic on enhanced MRI. 28,29 Enhanced MRI was considered an important evaluation measure for the early therapeutic response of uterine fibroids to HIFU.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Quantitative Uterine Fibroid Perfusion Parameters From Contrast‐Enhanced Ultrasound for the Therapeutic Effect of High‐Intensity Focused Ultrasound Ablation

Wang

Zhang

et al. 2018

J of Ultrasound Medicine

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Objectives To assess the predictive significance of quantitative perfusion parameters from contrast‐enhanced ultrasound (CEUS) for the therapeutic response to high‐intensity focused ultrasound (HIFU) ablation in patients with uterine fibroids. Methods A total of 263 patients with single uterine fibroids were treated with HIFU ablation under ultrasound guidance. The arrival time, peak time, enhancement time, enhancement intensity, and enhancement rate were evaluated with pretreatment CEUS. According to a nonperfused volume ratio evaluation by posttreatment magnetic resonance imaging, all patients were assigned to groups with volume ratios of 70% or higher and lower than 70%. Then the predictive performances of different parameters for ablation efficacy were studied. Results The arrival time, peak time, and enhancement time in the group with a nonperfused volume ratio of 70% or higher were longer than those in the group with a volume ratio lower than 70% (mean ± SD, 16.7 ± 3.5, 26.5 ± 4.9, and 10.2 ± 2.6 seconds, respectively, versus 13.3 ± 4.2, 20.8 ± 5.4, and 7.6 ± 2.3 seconds), whereas patients with a volume ratio of 70% or higher had a lower mean enhancement intensity and enhancement rate than those with a volume ratio lower than 70% (29.7 ± 16.7 dB and 3.2 ± 1.5 dB/s versus 63.2 ± 26.3 dB and 8.6 ± 4.3 dB/s; P < .05). The nonperfused volume ratio was negatively correlated with the enhancement intensity and enhancement rate (r = –0.631 and –0.712) but positively correlated with the arrival time, peak time, and enhancement time (r = 0.322, 0.456, and 0.477; P < .05). The areas under the receiver operating characteristic curve for the enhancement time, enhancement intensity, and enhancement rate were 0.73, 0.79, and 0.81 (P < .05). Conclusions Quantitative parameters from CEUS are potentially useful for evaluating the therapeutic effect of HIFU ablation for uterine fibroids.

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