1994
DOI: 10.1073/pnas.91.24.11487
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High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

Abstract: We report here that the Intrinsic affinities of the antigen-specific T-cell receptors (TCR) of two unrelated CD8+ T-cell clones for their respective peptide-major histocompatibility complex (MHC) ligands are higher than the values generally thought to prevail for TCR. The TCR of one clone (2C) binds an aflogeneic class I MHC protein (Ld) in association with an a-ketoglutarate dehydrogenase nonapeptide (QLSPFPFDL, termed QL9) with an intrinsic anity (intrinsic equilibrium association constant) of 1-2 x 107 M-1… Show more

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Cited by 183 publications
(162 citation statements)
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“…In contrast, both types of hybrids were equally sensitive to stimulation with anti-CD3 Abs (data not shown). Thus, these findings are in general agreement with the prior studies (28,29) and show that alloreactive T cells have lower activation thresholds than self-restricted T cells.…”
Section: A B /Ep-specific Alloreactive T Cells Are More Sensitive To supporting
confidence: 82%
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“…In contrast, both types of hybrids were equally sensitive to stimulation with anti-CD3 Abs (data not shown). Thus, these findings are in general agreement with the prior studies (28,29) and show that alloreactive T cells have lower activation thresholds than self-restricted T cells.…”
Section: A B /Ep-specific Alloreactive T Cells Are More Sensitive To supporting
confidence: 82%
“…It also remains to be determined whether the overall orientation and the exact positions of complementarity determining region (5) loops with respect to MHC and peptide ligands of alloreactive TCRs is similar to that of self-restricted TCRs. Third, it has been argued that alloreactive T cells depend more strongly on interactions with residues located on the ␣-helices of the allo-MHC and less on interactions with peptide residues (28,(35)(36)(37)(38). This idea is supported by studies that compared the ligand requirements for self vs alloantigen recognition of different MHC alleles by a single T cell clone (28,(35)(36)(37)(38).…”
supporting
confidence: 53%
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