High aldolase with normal creatine kinase in serum predicts a myopathy with perimysial pathology

Nozaki, Kenkichi; Pestronk, Alan

doi:10.1136/jnnp.2008.161448

Cited by 53 publications

(39 citation statements)

References 12 publications

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“…ILD may progress independently of the myopathy, be associated with mortality or severe disability and require additional immunomodulating treatments [11]. Laboratory associations with IMPP pathology include serum anti-tRNA synthetase antibodies, especially Jo-1 [21], and selectively elevated aldolase with normal creatine kinase [14]. Similar perimysial pathology occurs in graft-versus-host disease [14,22], fasciitis [21,23] and some toxic myopathies, but not in hereditary myopathies.…”

Section: Immune Myopathies With Perimysial Pathologymentioning

confidence: 97%

“…Myopathology in immune myopathies with perimysial pathology (IMPP) consistently involves perimysial connective tissue [14,21]. Perimysium is fragmented with scattered pale regions that appear empty ( Fig.…”

Section: Immune Myopathies With Perimysial Pathologymentioning

confidence: 99%

“…Clinical associations include symmetric, predominantly proximal muscle weakness, myalgias, interstitial lung disease (ILD), and skin pathology, most distinctively 'mechanic's hands', a hyperkeratotic rash at the edge of fingers and over joints [14,21]. IMPP patients with skin involvement are commonly classified clinically as dermatomyositis.…”

Section: Immune Myopathies With Perimysial Pathologymentioning

confidence: 99%

“…Some immune myopathy syndromes with myositis-specific antibodies include patients both with dermatomyositis and with polymyositis [3 , [11][12][13]. Clinical dermatomyositis syndromes are a pathologically heterogeneous group of immune disorders [14,15 ]. Polymyositis is a broad, now controversial [16,17], term with poor specificity that has traditionally been used to denote all inflammatory myopathies that are not dermatomyositis or IBM-like disorders [1,2,3 , 4,6].…”

Section: Introductionmentioning

confidence: 99%

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Acquired immune and inflammatory myopathies

Pestronk

2011

Current Opinion in Rheumatology

130

109

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Section: Immune Myopathies With Perimysial Pathologymentioning

confidence: 97%

Section: Immune Myopathies With Perimysial Pathologymentioning

confidence: 99%

Section: Immune Myopathies With Perimysial Pathologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acquired immune and inflammatory myopathies

Pestronk

2011

Current Opinion in Rheumatology

130

109

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“…In addition to a significant increase in serum LDH and CPK activities a sensitive marker of myopathy aldolase was significantly increased in zinc deficient sheep. The elevated serum aldolase is associated with syndromes including myopathies with discomfort and weakness, systemic disorders and myopathology in perimysial connective tissue (Nozaki and Pestronk, 2009). Moreover, the damage of muscle tissue can be defined as the disruption of plasma membrane accompanied by the loss of muscle proteins as CPK, myoglobin, LDH, aldolase and troponin (Tsitsimpikou et al, 2013).…”

Section: Ajavsmentioning

confidence: 99%

Biochemical Alterations in Zinc Deficient Sheep Associated by Hyperlactatemia

El‐Far¹

2013

American Journal of Animal and Veterinary Sciences

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Blood samples from diseased and clinically healthy Balady sheep of both sexes were collected and subjected for biochemical analysis of serum glucose, fructosamine, lactate, growth hormone, insulin, creatine phosphokinase, Lactate dehydrogenase and aldolase. The obtained results revealed a significant decrease in serum zinc and growth hormone were stated. In contrary, serum glucose and lactate, insulin, CPK, LDH and aldolase were significantly increased statically. While, fructosamine levels were non-significantly increased. From these results can conclude that, in zinc deficient sheep the carbohydrate metabolism is directed toward the anaerobic one accompanied by hyperlactemia which induce muscle cramp and damages leading to increased CPK, LDH and aldolase which appear clinically as enlargement of knee joint, lameness and staggering gait. In addition, growth retardation and wool loss are the main clinical signs of reduction in growth hormone.

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Inflammatory Myositis in Cancer Patients Receiving Immune Checkpoint Inhibitors

Aldrich

Pundole

Tummala

et al. 2021

Arthritis & Rheumatology

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Objective. To estimate the incidence of immune checkpoint inhibitor-related myositis (ICI-myositis) in cancer patients receiving ICIs, and to report associated clinical manifestations, patterns of care, and outcomes.Methods. We identified a retrospective cohort of patients receiving ICIs between 2016 and 2019 seen at the University of Texas MD Anderson Cancer Center. Cases of ICI-myositis were identified using International Classification of Disease codes and confirmed by reviewing medical records and pathology, as available.Results. A total of 9,088 patients received an ICI. Thirty-six patients (0.40%) were identified as having ICI-myositis: 17 patients (47%) with ICI-myositis alone and 19 (53%) with overlap manifestations (5 patients with myocarditis, 5 with myasthenia gravis, and 9 with both). The incidence of ICI-myositis was 0.31% in those receiving ICI monotherapy and 0.94% in those receiving combination ICI therapy (relative risk 3.1 [95% confidence interval 1.5-6.1]). Twenty-five patients (69%) received ≥1 treatment in addition to glucocorticoids: plasmapheresis in 17 patients (47%), intravenous immunoglobulin in 12 (33%), and biologics in 11 (31%). Patients with overlap conditions had worse outcomes than those with myositis alone, and 79% of them developed respiratory failure. Eight patients died as a result of ICImyositis, and all had overlap syndrome with myasthenia gravis or myocarditis (P < 0.05); 75% of these patients had a concomitant infection.Conclusion. ICI-myositis is a rare but severe adverse event. More than half of the patients presented with overlap manifestations and had deleterious outcomes, including respiratory failure and death. None of the patients with ICI-myositis alone died as a result of adverse events. Optimal treatment strategies have yet to be determined. PATIENTS AND METHODSPatients. We conducted a retrospective cohort study of patients seen at our institution between March 2016 and September 2019 who had received ≥1 of the following ICIs:

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High aldolase with normal creatine kinase in serum predicts a myopathy with perimysial pathology

Cited by 53 publications

References 12 publications

Acquired immune and inflammatory myopathies

Acquired immune and inflammatory myopathies

Biochemical Alterations in Zinc Deficient Sheep Associated by Hyperlactatemia

Inflammatory Myositis in Cancer Patients Receiving Immune Checkpoint Inhibitors

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