High and Low LET Radiation Differentially Induce Normal Tissue Damage Signals

Niemantsverdriet, Maarten; Goethem, Marc-Jan van; Bron, Reinier; Hogewerf, Wytse; Brandenburg, S.; Langendijk, Johannes A.; Luijk, Peter van; Coppes, Robert P.

doi:10.1016/j.ijrobp.2011.09.057

Cited by 62 publications

(45 citation statements)

References 33 publications

(60 reference statements)

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“…X-rays, gamma rays and charged particles are the most common types of radiation used for cancer treatment. Recent advances in radiotherapy have enabled the use of different types of radiation sources for a better cancer treatment efficacy [27] . Biological effects of IR on cellular molecules can be direct (target effects) and indirect (no target effects) [21,28] .…”

Section: Ir and Its Effects On The Cellmentioning

confidence: 99%

Research and Development of Radioprotective Agents: A Mini-Review

Saaya

Katsube

Xie

et al. 2017

International Journal of Radiology

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The research and development (R&D) of radioprotective agents (RAs) have been conducting since seven decades ago, and the safety and protection against undesirable effects of ionizing radiation (IR) has become an important issue especially for the benefit of patients receiving the radiotherapy, in addition to the applications in nuclear industry, military, outer space exploration and accidental exposures. Although the technology advancement makes the radiotherapy a promising better treatment by maximizing the effect of IR to the cancer cells, there are still needs for improvement in minimizing the toxicity to the normal cells. Aiming at providing the new researchers in the radiation protection field with an overall view for R&D of the RAs, this mini-review elucidates in brief a general understanding of the IR and its effects on the cell, the concepts of radiotherapy and therapeutic ratio, the categories of RAs and their mechanisms, and discusses on the strategies and challenge for R&D of the RAs.

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Section: Ir and Its Effects On The Cellmentioning

confidence: 99%

Research and Development of Radioprotective Agents: A Mini-Review

Saaya

Katsube

Xie

et al. 2017

International Journal of Radiology

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“…High LET has the potential to intensely damage regions of the cell membrane and its proteins, theoretically leading to a more robust antigen. Therefore, tumor cells at the edge of the SOBP may experience an enhanced rate of apoptosis due to the high LET that results in a higher ionization density within the cellular structure compared with the lower LET of photon radiation . Thus, we hypothesized that proton therapy may be a better upregulator of RITI compared with conventional photon radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Radiation‐induced tumor immunity in patients with non‐small cell lung cancer

et al. 2019

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Background Radiation‐induced tumor immunity (RITI) influences primary tumor growth and development of metastases in preclinical cancer models with conventional radiotherapy. Antigen‐specific immune responses have also been shown for prostate cancer treated with radiotherapy. We examined whether RITI can be induced in patients with non‐small cell lung cancer (NSCLC) following proton radiotherapy. Methods Pre‐ and post‐radiotherapy plasma samples from 26 patients with nonmetastatic NSCLC who received radiotherapy between 2010 and 2012 were evaluated by western blotting for IgG and IgM bands to assess RITI response to tumor antigens from lung cancer cell lines. Statistical analysis was used to evaluate any correlation among IgG or IgM and clinical outcomes. Results Twenty‐one patients received proton therapy at 2 GyRBE/fraction (n = 17) or 6–12 Gy/fraction (n = 4); five received photon therapy at 2–2.5 GyRBE/fraction. Compared with the pretreatment baseline, new IgG or IgM binding was detected in 27% and 50% of patients, respectively. New IgG bands were detected in the 25–37 kD, 50–75 kD, and 75–100 kD ranges. New IgM bands were detected in the 20–25 kD, 25–37 kD, 37–50 kD, 50–75 kD, and 75–100 kD ranges. There was no difference in IgG and/or IgM RITI response in patients treated with photons versus protons, or in patients who received SBRT compared to standard fractionation (P > 0.05). There was no difference in overall survival, metastasis‐free survival, or local control based on IgG and/or IgM RITI response (P > 0.05). Conclusion RITI can be induced in patients with NSCLC through upregulated IgG and/or IgM. RITI response was not associated with proton versus photon therapy or with clinical outcomes in this small cohort and should be examined in a larger cohort in future studies.

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“…In the recent reports, it has been demonstrated that High LET irradiation increases killing effects on the CSLCs of colorectal (2), pancreatic (7), glioblastoma (6,8), human tongue (9) and breast (10) cells. However, expensive establishment of high LET caused some limitations to access this modality (2,11). Therefore, the improvement of conventional radiotherapy effects by using some strategies such as application of a radiosensitizer can be considered as an effective and affordable method.…”

Section: Introductionmentioning

confidence: 99%

Combination of gold nanoparticles with low-LET irradiation: an approach to enhance DNA DSB induction in HT29 colorectal cancer stem-like cells

Abbasian

Baharlouei

Arab‐Bafrani

et al. 2018

J Cancer Res Clin Oncol

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High-linear energy transfer (High LET) irradiation has significant cytotoxic effects on different cancerous, stem-like, cells (CSLCs) such as colon CSLCs. A review of the literature has indicated that the presence of gold nanoparticles (GNPs) enables low LET irradiation to produce a highly non-homogeneous dose distributions like high LET irradiation.The purpose of this study was to evaluate the radio-responsiveness of HT29 colon CSLCs under low LET irradiation (X-ray) and in the presence of GNPs.Radio-responsiveness was evaluated using the ϒ-H2AX foci formation assay, the clonogenic assay, the cell cycle progression assay and analyses of radiobiological parameters.In the presence of GNPs, the survival fraction of HT29 CSCLs was significantly reduced, and caused significant changes in the radiobiological parameters after irradiation. In addition, ϒ-H2AX assay showed that in the presence of GNPs, the persistent DNA double strand breaks (DSBs) were significantly increased in irradiated HT29 CSLCs. The relative biological effectiveness (RBE) value of GNPs with Xrays was about 1.6 for HT-29 CSLCs at the D10 stage when compared to X-rays alone. Therefore, the combination of GNPs with X-ray irradiation has potential to kill HT29 CSLCs greater than the X-rays alone, and may be considered as an alternative for high LET irradiation.

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High and Low LET Radiation Differentially Induce Normal Tissue Damage Signals

Abstract: Our results indicate that diverse mechanisms involved in the development of normal tissue damage may be differentially affected by high and low LET radiation. This may have consequences for the development and manifestation of normal tissue damage.

Cited by 62 publications

References 33 publications

Research and Development of Radioprotective Agents: A Mini-Review

Research and Development of Radioprotective Agents: A Mini-Review

Radiation‐induced tumor immunity in patients with non‐small cell lung cancer

Combination of gold nanoparticles with low-LET irradiation: an approach to enhance DNA DSB induction in HT29 colorectal cancer stem-like cells

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