2019
DOI: 10.1159/000499590
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High BrdU Sensitivity of Passeriformes Chromosomes: Conservation of BrdU-Sensitive Fragile Sites on Their Z Chromosomes during Evolution

Abstract: Amongst 15 bird species, representative of 7 orders, recurrent breakages evocating the presence of fragile sites were detected in the chromosomes of the 5 species belonging to Passeriformes. These breaks appeared when 5-bromodeoxyuridine (BrdU) was added to the cell culture medium at a dose inefficient for inducing chromosome structure alterations in other birds and mammals. They involved, similarly in male and female, 3 loci on the Z chromosome of 3 Turdus species (Turdidae). Labeling by BrdU antibody confirm… Show more

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“…By further contemplating the conservation of FSs not only within the mammalian lineage [84][85][86][87] but also in avian species [53,88] and even the occurrence of somewhat similar sites in insects [89], yeast [90] and plants [91,92], it is tempting to speculate on the function of these sites. We suggest a balancer and memory function of FSs in the context of the incompatibility of cell division and cellular senescence to keep an equilibrium between the chance of self-renewal and regeneration as well as cancerogenic overgrowth and ageing, respectively.…”
Section: Conclusion Main Messages and Future Perspectivesmentioning
confidence: 99%
“…By further contemplating the conservation of FSs not only within the mammalian lineage [84][85][86][87] but also in avian species [53,88] and even the occurrence of somewhat similar sites in insects [89], yeast [90] and plants [91,92], it is tempting to speculate on the function of these sites. We suggest a balancer and memory function of FSs in the context of the incompatibility of cell division and cellular senescence to keep an equilibrium between the chance of self-renewal and regeneration as well as cancerogenic overgrowth and ageing, respectively.…”
Section: Conclusion Main Messages and Future Perspectivesmentioning
confidence: 99%