High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome

Xia, Fang; Zhang, Tingran; Yang, Gangyi; Cheng, Zhigang; Hu, Wenjing; Xia, Fan; Liu, Hua; Zhu, Zhiming; Liu, Dongfang; Wang, Cong-Yi; Gu, Harvest F.; Li, Rui

doi:10.1159/000495823

Cited by 10 publications

(20 citation statements)

References 26 publications

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“…A positive correlation was observed between alarin levels and fasting glucose levels, glycosylated hemoglobin (HbA1c) levels, and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). 21 PCOS is accompanied by dyslipidemia, central obesity, and insulin resistance, similar to MetS. As in MetS, alarin levels were demonstrated to be higher in patients with PCOS in previous studies.…”

Section: Discussionmentioning

confidence: 77%

“…In human studies, circulating alarin levels were found higher in women diagnosed as having metabolic syndrome (MetS). A positive correlation was observed between alarin levels and fasting glucose levels, glycosylated hemoglobin (HbA1c) levels, and Homeostatic Model Assessment of Insulin Resistance (HOMA‐IR) 21 . PCOS is accompanied by dyslipidemia, central obesity, and insulin resistance, similar to MetS.…”

Section: Discussionmentioning

confidence: 99%

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Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case–control study

Görkem

Yıldırım

2022

J of Obstet and Gynaecol

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Aim: There is scant evidence concerning the relationship of alarin concentrations for polycystic ovary syndrome (PCOS) status in the existing literature. Therefore, we aimed to reveal the relationship about predictive value of serum alarin concentrations for PCOS risk in infertile women. Methods: This prospective case-control study included a total of 151 infertile women who met eligibility criteria of the study. Infertile women diagnosed with PCOS formed the study group (n = 80). Women with diagnoses of unexplained infertility constituted the control group (n = 71). The biochemical analyses of serum concentrations of lipid profiles, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Mullerian hormone (AMH) and alarin were performed. Results: There were no differences for the study parameters, including age, body mass index, fasting glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total triglyceride, E2, and FSH levels in either group. Serum LH, AMH, alarin concentrations, and antral follicle counts had higher values in the PCOS group compared with the controls. Correlation analysis revealed that serum alarin levels were significantly positively correlated with LH and AMH levels, only in the PCOS group. Multivariate binary logistic regression analysis demonstrated that infertile women with high alarin concentrations were significantly more likely to develop PCOS (OR = 1.77, 95% CI = 0.095-0.332, p < 0.001). Conclusion: Higher serum concentrations of alarin and a positive correlation with serum LH levels were found in infertile women with PCOS. This evidence supported that high alarin concentrations might play a role in the development of PCOS.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case–control study

Görkem

Yıldırım

2022

J of Obstet and Gynaecol

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“…Free fatty acid (FFA) was measured with a commercial kit (Randox Laboratories). Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were analyzed enzymatically using an autoanalyzer (Hitachi) as in a previous report [19]. Serum hormonal levels including total testosterone (TEST), follicle-stimulating hormone (FSH), estradiol (E2) and luteinizing hormone (LH) were examined with electrochemiluminescence immunoassay using COBAS E immunoassay analyzers (Roche Diagnostics GmbH).…”

Section: Biochemical and Hormone Measurementsmentioning

confidence: 99%

Several Circulating Biomarkers for PCOS Diagnosis

Luo

Zhang

et al. 2019

Exp Clin Endocrinol Diabetes

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Aims Irisin, Betatrophin and Zinc-α2-glycoprotein (ZAG) have been shown to be associated with insulin resistance (IR) and polycystic ovary syndrome (PCOS), respectively. The purpose of this study is to explore the potential accuracy of this combination of three cytokines in screening PCOS. Methods 186 individuals were recruited for this study. Circulating Irisin, Betatrophin and ZAG concentrations were measured by enzyme-linked immunosorbent assay. The association between these serum biomarkers and PCOS was assessed by logistic regression analysis. Receiver operating curve (ROC) analysis was performed to evaluate the diagnostic value of these biomarkers for PCOS women. Results In women with PCOS, serum Irisin and Betatrophin levels were markedly elevated compared to those in healthy controls (p<0.01), while ZAG levels were lower (p<0.01). PCOS women with IR (M-value<6.28) had lower circulating ZAG concentrations, and higher circulating Irisin and Betatrophin levels relative to PCOS women without IR (M-value ≥ 6.28). ROC curve analyses showed that the AUC for Irisin, ZAG and Betatrophin for predicting PCOS were 0.77, 0.83 and 0.85, respectively. In a joint ROC curves analysis of these serum markers and other parameters, the results showed that the AUC was 0.93, and the sensitivity and specificity were 82.1 % and 92.3 %, respectively. Conclusions When compared to using single cytokine, the analysis of Irisin, ZAG and Betatrophin elevates the accuracy in diagnosing PCOS.

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“…In vivo studies have also reported that Alarin may be released in response to metabolic stress factors such as abdominal obesity, insulin resistance, dyslipidemia, hyperglycemia, and hypertension. [ 19 ]. In patients with metabolic syndrome and obesity, Alarin levels have been determined to be higher than those of control groups.…”

Section: Discussionmentioning

confidence: 99%

Plasma and aqueous levels of alarin and adipsin in patients with and without diabetic retinopathy

Gül¹,

Kobat

Çelik

et al. 2022

BMC Ophthalmol

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Backround Diabetic retinopathy is a disease seen with microvascular complications as a result of hyperglycemia and insulin resistance. Alarin and Adipsin are molecules with a role in energy and glucose metabolism. The aim of this study was to determine plasma and aqueous levels of Alarin and Adipsin in patients with and without diabetic retinopathy to evaluate their potential roles in diabetic retinopathy. Methods The study included one eye from each of 20 cataract patients without diabetes (C), 20 cataract patients with diabetes and without diabetic retinopathy (DM + C), and 20 cataract patients with diabetes and diabetic retinopathy (DR + C). Plasma and aqueous humour samples were taken from all patients during the cataract operation. Alarin and Adipsin levels were examined with the enzyme-linked immunosorbent assay (ELISA) method. Results Both plasma and aqueous Alarin levels were significantly higher in the patients with diabetic retinopathy than in the control group (p < 0.001, p = 0.006). Adipsin levels were found to be significantly higher in plasma in the control group than in the DR + C group and significantly higher in aqueous in the DR + C group than in the control group (p < 0.001, p < 0.001). Conclusion These findings suggest that Alarin and Adipsin may play important role in diabetic retinopathy.

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High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome

Cited by 10 publications

References 26 publications

Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case–control study

Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case–control study

Several Circulating Biomarkers for PCOS Diagnosis

Plasma and aqueous levels of alarin and adipsin in patients with and without diabetic retinopathy

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