High circulating microRNA-122 expression is a poor prognostic marker in patients with hepatitis B virus-related hepatocellular carcinoma who undergo radiofrequency ablation

Cho, Hyo Jung; Kim, Jai Keun; Nam, Ji Sun; Wang, Hee Jung; Lee, Jei Hee; Kim, Bong-Wan; Kim, Soon Sun; Noh, Choong‐Kyun; Shin, Sung Jae; Lee, Kee Myung; Cho, Sung Won; Cheong, Jae Youn

doi:10.1016/j.clinbiochem.2015.06.019

Cited by 41 publications

(39 citation statements)

References 31 publications

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“…Circulating miR-122-5p and miR-16-5p could be used as putative biomarkers for HCC. Among them, miR-122-5p and miR-16-5p were shown to be up and down-regulated, respectively4950.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, hepatic necroinflammatory activity was associated with the high expression of miR-122-5p in plasma. The over expression of circulating miR-122-5p was a prognostic biomarker predicting the poor survival rate of patients underwent radio frequency ablation49.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, miR-101-3p, miR-122-5p, miR-125b-5p, miR-130a-3p, miR-146a-5p, miR-214-3p and miR-99a-5p were considered as tumor suppressors in HCC and served as prognostic indicators for HCC3899100101102103104. Serum miR-1-3p, miR-101-3p, miR-122-5p, miR-150-5p, miR-203a-3p and miR-30c-5p were associated with suppressing tumorigenicity and new independent parameters of overall survival in HCC3849607791105.…”

Section: Resultsmentioning

confidence: 99%

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Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Shen

Lin

Yuan

et al. 2016

Sci Rep

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Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors with high incidence and mortality rate. Precision and effective biomarkers are therefore urgently needed for the early diagnosis and prognostic estimation. MicroRNAs (miRNAs) are important regulators which play functions in various cellular processes and biological activities. Accumulating evidence indicated that the abnormal expression of miRNAs are closely associated with HCC initiation and progression. Recently, many biomarker miRNAs for HCC have been identified from blood or tissues samples, however, the universality and specificity on clinicopathological features of them are less investigated. In this review, we comprehensively surveyed and compared the diagnostic, prognostic, and therapeutic roles of HCC biomarker miRNAs in blood and tissues based on the cancer hallmarks, etiological factors as well as ethnic groups, which will be helpful to the understanding of the pathogenesis of biomarker miRNAs in HCC development and further provide accurate clinical decisions for HCC diagnosis and treatment.

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“…Circulating miR-122-5p and miR-16-5p could be used as putative biomarkers for HCC. Among them, miR-122-5p and miR-16-5p were shown to be up and down-regulated, respectively4950.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Shen

Lin

Yuan

et al. 2016

Sci Rep

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“…Recently, we have evaluated the association between plasma miR‐122 levels and prognosis after surgery or radiofrequency ablation, in HCC patients. In contrast with the previous studies, high plasma miR‐122 level was demonstrated to be an independent risk factor for poor overall survival in patients treated with radiofrequency ablation . This study also included HBV‐related HCC patients, and we used the same cut‐off value for plasma miR‐122 levels as here.…”

Section: Discussionmentioning

confidence: 99%

Plasma micoRNA‐122 as a predictive marker for treatment response following transarterial chemoembolization in patients with hepatocellular carcinoma

Kim

Nam

Cho

et al. 2017

J of Gastro and Hepatol

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“…Furthermore, high levels of PRDX II mRNA targeting miRNA, miR-122 [44], associated with the dismal outcome in the current material. The prognostic role of miR-122 has been previously quite extensively studied especially in hepatocellular carcinoma with both worse and better survival being reported [45–47]. …”

Section: Discussionmentioning

confidence: 99%

Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas

Karihtala

Porvari

Soini

et al. 2017

Oxidative Medicine and Cellular Longevity

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There are no previous studies assessing the microRNAs that regulate antioxidant enzymes in Hodgkin lymphomas (HLs). We determined the mRNA levels of redox regulating enzymes peroxiredoxins (PRDXs) I–III, manganese superoxide dismutase (MnSOD), nuclear factor erythroid-derived 2-like 2 (Nrf2), and Kelch-like ECH-associated protein 1 (Keap1) from a carefully collected set of 41 classical HL patients before receiving any treatments. The levels of redoxmiRs, miRNAs known to regulate the above-mentioned enzymes, were also assessed, along with CD3, CD20, and CD30 protein expression. RNAs were isolated from freshly frozen lymph node samples and the expression levels were analyzed by qPCR. mir23b correlated inversely with CD3 and CD20 expressions (p = 0.00076; r = −0.523 and p = 0.0012; r = −0.507) and miR144 with CD3, CD20, and CD30 (p = 0.030; r = −0.352, p = 0.041; r = −0.333 and p = 0.0032; r = −0.47, resp.). High MnSOD mRNA levels associated with poor HL-specific outcome in the patients with advanced disease (p = 0.045) and high miR-122 levels associated with worse HL-specific survival in the whole patient population (p = 0.015). When standardized according to the CD30 expression, high miR212 and miR510 predicted worse relapse-free survival (p = 0.049 and p = 0.0058, resp.). In conclusion, several redoxmiRs and redox regulating enzyme mRNA levels associate with aggressive disease outcome and may also produce prognostic information in classical HL.

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High circulating microRNA-122 expression is a poor prognostic marker in patients with hepatitis B virus-related hepatocellular carcinoma who undergo radiofrequency ablation

Cited by 41 publications

References 31 publications

Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Plasma micoRNA‐122 as a predictive marker for treatment response following transarterial chemoembolization in patients with hepatocellular carcinoma

Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas

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