High circulating miR‐18a, miR‐20a, and miR‐92a expression correlates with poor prognosis in patients with non‐small cell lung cancer

Xu, Xiaoxiao; Zhu, Shan; Zeng, Tao; Ye, Shenglan

doi:10.1002/cam4.1238

Cited by 69 publications

(53 citation statements)

References 45 publications

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“…Third through checking the full-text and data integrity, 46 articles were further excluded. Finally, 13 studies that met all the inclusion criteria were included in the present study, containing 5 studies on the diagnostic accuracy of miR-126 and NSCLC [19][20][21][22][23] and 8 studies on miR-126 and the prognosis of NSCLC [16,[24][25][26][27][28][29][30]. Specific screening flow chart was presented in Figure 1.…”

Section: Literature Research and Characteristic Of Studiesmentioning

confidence: 99%

Meta-analysis of diagnostic and prognostic value of miR-126 in non-small cell lung cancer

Sun¹,

Zhou²,

Yang³

et al. 2020

Bioscience Reports

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In recent years, many studies on the relationship between the expression of microRNA-126 (miR-126) and the diagnostic and prognostic value of non-small cell lung cancer (NSCLC) have been made, but the results were still controversial. The aim is to explore the expression of miR-126 and the diagnosis and prognosis value of NSCLC, and to provide relevant evidence for clinical diagnosis and treatment. Literature related to miR-126 and NSCLC were searched in PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang from the inception to February 2020. Stata 15.0 was used for meta-analysis. The diagnostic value data were used to calculate the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and the prognostic value data were used to calculate the pooled risk ratio (hazard ratio, HR) of overall survival (OS) and its 95% confidence interval (95% CI). Thirteen studies were included, among which five were related to diagnosis containing 439 patients and 463 healthy controls, and eight related to prognosis containing 1102 patients. The results of miR-126 expression and diagnostic value of NSCLC showed that the pooled sensitivity was 0.83 (95% CI: 0.59–0.94), specificity = 0.83 (95% CI: 0.71–0.90), PLR = 4.78 (95% CI: 2.97–7.69), NLR = 0.20 (95% CI: 0.08–0.54), DOR = 23.48 (95% CI: 7.87–70.10), and the area under the summ ary receiver operating characteristic curve (SROC) was 0.89 (95% CI: 0.86–0.91). The results of prognostic value indicated that the expression of miR-126 was related to the OS of NSCLC (HR = 0.79, 95% CI: 0.63–0.98). In conclusion, the expression of miR-126 has medium diagnostic value, and it is related to the prognosis of patients with NSCLC, with poor prognosis of miR-126 low expression.

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Section: Literature Research and Characteristic Of Studiesmentioning

confidence: 99%

Meta-analysis of diagnostic and prognostic value of miR-126 in non-small cell lung cancer

Sun¹,

Zhou²,

Yang³

et al. 2020

Bioscience Reports

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“…Then we did a bioinformatics study based on public miRNA array data and demonstrated that miR-20a-5p as a candidate to regulate WTX. It was reported that miR-20a was highly expressed in hepatocellular carcinoma [43], lung cancer [44], colon cancer [45] and other tumors [46,47] and acts as an oncogene. And miR-20a can be used as a biomarker in the diagnosis and prognosis of GC [48,49].…”

Section: Discussionmentioning

confidence: 99%

Mir-20a-5p Induced WTX Deficiency Promotes Gastric Cancer Progressions Through Regulating PI3K/AKT Signaling Pathway

Shen

et al. 2020

Preprint

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Background: The X-linked gene WTX (also called AMER1), has been reported to act as a tumor suppress gene in Wilms tumor. Our previous study reported that WTX expression was significantly reduced in gastric cancer (GC), but the function and mechanism of WTX loss had not been fully elucidated yet. Methods: WTX/miR-20a-5p expression was analyzed in paraffin-embedded archived GC tissues and validated in public databases. KEGG pathway analyses were performed to explore the mechanism of WTX in GC progression. The role of WTX/miR-20a-5p in cell growth, migration, invasion and angiogenesis was investigated in vitro and in vivo. Western blot, immunohistochemistry, RT-PCR, luciferase assay, and Co-immunoprecipitation (Co-IP) were used to detect the regulation of WTX and PI3K/AKT/mTOR signaling by miR-20a-5p.Results: We revealed that WTX served as a tumor suppressor whose loss associated with the aggressive feature of GC by showing hyperproliferation in vitro and high metastasis phenotype in vivo. And WTX expression level was positively correlated with the overall survival of GC patients. Microarray, bioinformatics analysis, and verification experiments showed that WTX loss activated PI3K/AKT/mTOR pathway, and promoted the proliferation and invasion of GC cells. We also discovered that the miR-20a-5P aberrant upregulation was one of the reasons inducing WTX loss in GC which stimulated PI3K phosphorylation to activate PI3K/AKT/mTOR signaling pathway, thus promoted GC progression.Conclusions: This study unveiled the mechanism of GC progression which was, at least partially, caused by miR-20a-5p aberrant upregulation which inhibited WTX expression and thus activate PI3K/AKT/mTOR signaling pathway. It provided a comprehensive understanding of the action of miR-20a-5p/WTX/PI3K/AKT/mTOR signaling pathway in the progression and metastasis of GC.

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“…A previous study revealed that miR-18a may be highly expressed in lung cancer and may function as an oncogene in the development of the disease (17). Increased circulating miR-18a may also be a prognostic factor for lung cancer (18). A meta-analysis revealed that miR-18a may be a promising biomarker for the diagnosis of patients with gastric carcinoma (19).…”

Section: Discussionmentioning

confidence: 99%

Screening of key miRNAs and evaluation of their diagnostic and prognostic values in nasopharyngeal carcinoma

Zhuo

Zhou

et al. 2019

Oncol Lett

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Increasing evidence has revealed the importance of microRNA (miRNA/miR) in cancer genesis and progression. The aim of the current study was to identify the key miRNAs involved in the onset and development of nasopharyngeal carcinoma (NPC) and to further evaluate their diagnostic and prognostic values. Microarray data were obtained and analyzed to screen differentially expressed miRNAs (DEMs) between patients with NPC and healthy controls. The target genes of the DEMs were predicted and their possible functions were evaluated. The diagnostic and prognostic values of the DEMs were subsequently investigated. A total of 4 DEMs, including miR-18a, miR-135b, miR-204 and miR-497, were identified. Gene Ontology (GO) and pathway enrichment analysis revealed that the target genes were enriched in a number of GO terms and signaling pathways. The results demonstrated that the selected DEMs may present potential diagnostic factors for NPC. In addition, miR-18a [Hazard ratio (HR), 3.405; 95% confidence interval (CI), 1.334-8.693] and miR-135b (HR, 2.482; 95% CI, 1.014-6.076) may serve prognostic roles for patients with NPC. In summary, the present study identified 4 miRNAs that may be involved in the genesis and development of NPC. In addition, miR-18a and miR-135b may present useful prognostic markers for patients with NPC. Future in vitro and in vivo investigations are warranted to substantiate the results obtained in the current study.

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High circulating miR‐18a, miR‐20a, and miR‐92a expression correlates with poor prognosis in patients with non‐small cell lung cancer

Cited by 69 publications

References 45 publications

Meta-analysis of diagnostic and prognostic value of miR-126 in non-small cell lung cancer

Meta-analysis of diagnostic and prognostic value of miR-126 in non-small cell lung cancer

Mir-20a-5p Induced WTX Deficiency Promotes Gastric Cancer Progressions Through Regulating PI3K/AKT Signaling Pathway

Screening of key miRNAs and evaluation of their diagnostic and prognostic values in nasopharyngeal carcinoma

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