High circulating osteoprotegerin levels are associated with non-zero blood groups

Abstract

BackgroundOsteoprotegerin (OPG) and von Willebrand factor (VWF) form complex within endothelial cells and following secretion. The nature of blood group antigens strongly influences the levels of circulating VWF, but there is no available data concerning its ascendancy on OPG levels. We aimed to assess the relationship of AB0 blood groups with OPG, VWF levels (VWF: Ag) and collagen binding activity (VWF: CB) in peripheral arterial disease (PAD) patients.MethodsFunctional and laboratory parameters of 105 PAD patients and 109 controls were examined. Results of OPG, VWF: Ag, VWF: CB (ELISA-s) were analysed by comparative statistics, together with clinical data.ResultsOPG levels were higher in patients than in controls (4.64 ng/mL vs. 3.68 ng/mL, p < 0.001). Among patients elevation was marked in the presence of critical limb ischemia (5.19 ng/mL vs. 4.20 ng/mL, p = 0.011). The OPG in patients correlated positively with VWF: Ag and VWF: CB (r = 0.26, p = 0.008; r = 0.33, p = 0.001) and negatively with ankle-brachial pressure index (r = -0.22, p = 0.023). Furthermore, OPG was significantly elevated in non-0 blood groups compared to 0-groups both in patients and controls (4.95 ng/mL vs. 3.90 ng/mL, p = 0.012 and 4.09 ng/mL vs. 3.40 ng/mL, p = 0.002).ConclusionsOPG levels are associated to blood group phenotypes and higher in non-0 individuals. Increased OPG levels in PAD characterize disease severity. The significant correlation between OPG and VWF:CB might have functional importance in an atherothrombosis-prone biological environment.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-016-0287-2) contains supplementary material, which is available to authorized users.

Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects

“…All together these studies took in account the endothelial dysfunction, an early and important trigger of atherogenesis, as mechanism responsible for PAD development and worsening. In this direction an interesting significant association of high OPG was found with the non-0 blood groups in PAD patients, considering that non-0 blood group subjects have a well-established higher risk of developing thrombotic episode of venous or arterial origin [ 49 ].…”

TRAIL, OPG, and TWEAK in kidney disease: biomarkers or therapeutic targets?

“…As reported for TRAIL, the blood levels of OPG are in the picogram (per milliliter) range with reported physiological fluctuations due to age and gender as well the blood-group, with higher circulating levels associated with non-zero blood groups [70]. OPG circulating levels change in several diseases.…”

The Pathogenesis of Atherosclerosis Based on Human Signaling Networks and Stem Cell Expression Data

“…Atherosclerosis-risk Absent Modules were only identified from the normal weighted signaling network, which were crucial to maintain the normal cell regulation and transport function. Absence of these modules in disease status would lead to the disorder of the signal of stem cells and the change of the internal environment so as to participate in the pathogenesis of atherosclerosis 24 - 27 , 47 , 48 . The 3 Atherosclerosis-risk Absent Modules enriched significantly in the functional categories related to the maintenance of normal biological process, including “GO:0031328~positive regulation of cellular biosynthetic process”, “GO:0051173~positive regulation of nitrogen compound metabolic process” and “GO:0006935~chemotaxis”.…”