High correlation between salivary cortisol awakening response and the psychometric profiles of healthy children

Shibuya, Ikuhiko; Nagamitsu, Shinichiro; Okamura, Hisayoshi; Ozono, Shuichi; Chiba, Hiromi; Ohya, Takashi; Yamashita, Yushiro; Matsuishi, Toyojiro

doi:10.1186/1751-0759-8-9

Cited by 19 publications

(12 citation statements)

References 25 publications

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“…Cetaceans have the largest brains and among the longest lifespans of any mammal [33] and are considered by some to rival primates in their complex cognition [34,35]. Pathologies resulting from sleep deprivation in land mammals may be the result of stress induced by the sleep deprivation procedure, particularly the repeated awakenings, which may reach 1,000 a day, linked to the cortisol awakening response [6,36,37] and phasic changes in brain neuronal activity and neurochemistry, including monoamine release [2].…”

Section: Figure 4 Cumulative Loss Of Projected Rem Sleep Time In Seamentioning

confidence: 99%

Fur Seals Suppress REM Sleep for Very Long Periods without Subsequent Rebound

Lyamin

Kosenko

Korneva³

et al. 2018

Current Biology

100

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Virtually all land mammals and birds have two sleep states: slow-wave sleep (SWS) and rapid eye movement (REM) sleep [1, 2]. After deprivation of REM sleep by repeated awakenings, mammals increase REM sleep time [3], supporting the idea that REM sleep is homeostatically regulated. Some evidence suggests that periods of REM sleep deprivation for a week or more cause physiological dysfunction and eventual death [4, 5]. However, separating the effects of REM sleep loss from the stress of repeated awakening is difficult [2, 6]. The northern fur seal (Callorhinus ursinus) is a semiaquatic mammal [7]. It can sleep on land and in seawater. The fur seal is unique in showing both the bilateral SWS seen in most mammals and the asymmetric sleep previously reported in cetaceans [8]. Here we show that when the fur seal stays in seawater, where it spends most of its life [7], it goes without or greatly reduces REM sleep for days or weeks. After this nearly complete elimination of REM, it displays minimal or no REM rebound upon returning to baseline conditions. Our data are consistent with the hypothesis that REM sleep may serve to reverse the reduced brain temperature and metabolism effects of bilateral nonREM sleep, a state that is greatly reduced when the fur seal is in the seawater, rather than REM sleep being directly homeostatically regulated. This can explain the absence of REM sleep in the dolphin and other cetaceans and its increasing proportion as the end of the sleep period approaches in humans and other mammals.

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Section: Figure 4 Cumulative Loss Of Projected Rem Sleep Time In Seamentioning

confidence: 99%

Fur Seals Suppress REM Sleep for Very Long Periods without Subsequent Rebound

Lyamin

Kosenko

Korneva³

et al. 2018

Current Biology

100

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“…Studies examining the HPA axis have predominantly focused on salivary samples due to the ease and noninvasive nature of this collection method (e.g., Koss et al., 2014; Nater et al., 2005; Shibuya et al., 2014). A complementary measure involves examining hair cortisol concentrations (HCC).…”

Section: Introductionmentioning

confidence: 99%

Maternal expressive suppression moderates the relations between maternal and child hair cortisol

Doan

Venkatesh

Predroza

et al. 2020

Developmental Psychobiology

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Stress is contagious, influencing multiple domains within a person, as well as other close individuals (Pearlin, Aneshensel, & LeBlanc, 1997), particularly within families (Guajardo, Snyder, & Petersen, 2009; Pearlin et al., 1997; Thoits, 2010). Experiences of stress within mother-child dyads mutually accelerate and reinforce one another (Patterson & McCubbin, 1983). Parents are social regulators of children's emotions (Barthel, Hay, Doan, & Hofmann, 2018). Thus parents' and children's levels of self-reported stress are linked (Compas, Howell, Phares, Williams, & Ledoux, 1989). In addition, mother-child saliva cortisol levels, the end product of the hypothalamic-pituitary-adrenal axis, (HPA), a primary stress response system, are also correlated (Stenius et al.,

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“…Mean (SD) score for TMD of POMS was 205.6 (59.4). The subscale scores of Tension–Anxiety and Depression–Dejection were higher than normal ranges ( 26 ), but the differences did not reach significance. Mean (SD) IQ was 105 ( 13 ).…”

Section: Resultsmentioning

confidence: 73%

Altered SPECT 123I-iomazenil Binding in the Cingulate Cortex of Children with Anorexia Nervosa

et al. 2016

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Several lines of evidence suggest that anxiety plays a key role in the development and maintenance of anorexia nervosa (AN) in children. The purpose of this study was to examine cortical GABA(A)-benzodiazepine receptor binding before and after treatment in children beginning intensive AN treatment. Brain single-photon emission computed tomography (SPECT) measurements using 123I-iomazenil, which binds to GABA(A)-benzodiazepine receptors, was performed in 26 participants with AN who were enrolled in a multimodal treatment program. Sixteen of the 26 participants underwent a repeat SPECT scan immediately before discharge at conclusion of the intensive treatment program. Eating behavior and mood disturbances were assessed using Eating Attitudes Test with 26 items (EAT-26) and the short form of the Profile of Mood States (POMS). Clinical outcome scores were evaluated after a 1-year period. We examined association between relative iomazenil-binding activity in cortical regions of interest and psychometric profiles and determined which psychometric profiles show interaction effects with brain regions. Further, we determined if binding activity could predict clinical outcome and treatment changes. Higher EAT-26 scores were significantly associated with lower iomazenil-binding activity in the anterior and posterior cingulate cortex. Higher POMS subscale scores were significantly associated with lower iomazenil-binding activity in the left frontal, parietal cortex, and posterior cingulate cortex (PCC). “Depression–Dejection” and “Confusion” POMS subscale scores, and total POMS score showed interaction effects with brain regions in iomazenil-binding activity. Decreased binding in the anterior cingulate cortex and left parietal cortex was associated with poor clinical outcomes. Relative binding increases throughout the PCC and occipital gyrus were observed after weight gain in children with AN. These findings suggest that cortical GABAergic receptor binding is altered in children with AN. This may be a state-related change, which could be used to monitor and guide the treatment of eating disorders.

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High correlation between salivary cortisol awakening response and the psychometric profiles of healthy children

Cited by 19 publications

References 25 publications

Fur Seals Suppress REM Sleep for Very Long Periods without Subsequent Rebound

Fur Seals Suppress REM Sleep for Very Long Periods without Subsequent Rebound

Maternal expressive suppression moderates the relations between maternal and child hair cortisol

Altered SPECT 123I-iomazenil Binding in the Cingulate Cortex of Children with Anorexia Nervosa

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