High-definition transcranial direct current stimulation of the dorsal anterior cingulate cortex modulates decision-making and executive control

Mattavelli, Giulia; Presti, Sara Lo; Tornaghi, Diana; Canessa, Nicola

doi:10.1007/s00429-022-02456-3

Cited by 14 publications

(28 citation statements)

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“…To fill this gap, we took a meta-analytic approach to compare the behavioural and neural effects of the three most popular types of intervention, that is, cognitive, These clusters connect with segregated networks (Figure 4b-d) that, however, overlap in the midcingulate cortex (Figure 4e). This region is considered an emerging target for neurostimulation (Downar et al, 2016;Mattavelli et al, 2022), because of its role in multiple facets of self-regulation and control, via performance monitoring, feedback detection and behavioural adjustments to improve performance based on both endogenous (e.g., goals) and exogenous (e.g., context) factors (Ridderinkhof et al, 2004). Importantly, this hypothesis is mostly based on fMRI data showing transient responses in the posterior fronto-medial cortex to multiple facets of preresponse conflict and post-response feedback-based learning (Venkatraman et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Cognition, body, and mind: A three‐in‐one coordinate‐based fMRI meta‐analysis on cognitive, physical, and meditative trainings

Presti

Origlia

Gianelli

et al. 2023

Human Brain Mapping

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While mounting evidence shows promising effects of brain training on cognitive functioning in healthy and pathological conditions, the spread of variable training approaches highlights the need to compare their efficacy and identify their neural correlates, representing possible targets for neuromodulation treatments. We performed coordinate‐based functional magnetic resonance imaging meta‐analyses to compare the neural correlates and the cognitive outcomes of cognitive (n = 22), physical (n = 22), and meditative (n = 20) training in healthy non‐expert individuals. Pre/post‐training cognitive metrics improved after cognitive and physical training, but their heterogeneity, or even the lack of these measurements in some studies, highlights the need of more structured protocols. Cognitive, physical, and meditative interventions increased brain activity in distinct fronto‐medial areas likely mediating training effects on cognitive, action, and attentional control, respectively. The modular, training‐specific, engagement of a region that is known to mediate feedback‐based learning provides cues for boosting brain training via combined interventions that might jointly outperform their individual effects.

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Section: Discussionmentioning

confidence: 99%

Cognition, body, and mind: A three‐in‐one coordinate‐based fMRI meta‐analysis on cognitive, physical, and meditative trainings

Presti

Origlia

Gianelli

et al. 2023

Human Brain Mapping

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Section: Cortical Targetmentioning

confidence: 99%

“…Interestingly, by matching HD-tDCS with high standard modeling and targeting procedures, recent studies attempted to reach and modulate the dACC during task performance. Mattavelli et al (2022) , for example, relying on current modeling, optimized the HD-tDCS montage ( Figure 1B ) and delivered 20 min of 1 mA DC by using three circular, small (∼1 cm 2 ) anodes over Fz-F1-FCz and three cathodes over PO9-O9-O10 to target the dACC. Following a within-subject cross-over design, participants were asked to complete behavioral tasks such as the Arrow-Flanker, while receiving one of the three stimulation conditions (i.e., atDCS and ctDCS, and sham) in different days.…”

Section: The Application Of Polarized Direct Current To Probe Spatial...mentioning

confidence: 99%

“…Here, the conflict arises when the spatial position of the target and the response side do not correspond (i.e., the green circle appears on the right). The middle panel (B) displays three examples of electrodes’ montage in transcranial alternating current stimulation studies (from left to right, Fusco et al, 2022 ; Khan et al, 2022 ; and Mattavelli et al, 2022 ). The lower panel (C) shows three different views of 3D cortical maps representing the electric field intensity distribution (simulated through the open-source software ROAST; https://www.parralab.org/roast/ ; Huang et al, 2019 ) of six tES experimental studies differing for both the employed electrodes sizes and montages; from left to right: (i) the axial views of two transcranial direct current stimulation (tDCS) studies both employing a conventional bipolar tDCS montage with two rectangular electrodes of 25 cm 2 ( Adelhöfer et al, 2021 ) and 35 cm 2 ( Bellaïche et al, 2013 ); (ii) the saggital views of two transcranial alternating current stimulation (tACS) studies employing a conventional tACS montage with two circular electrodes of 25 cm 2 ; (iii) the antero-sagittal views of two HD-tDCS studies both employing a 4 returns × 1 active ring-like montage.…”

Section: Introductionmentioning

confidence: 99%

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Neuromodulating the performance monitoring network during conflict and error processing in healthy populations: Insights from transcranial electric stimulation studies

Fusco

Cristiano

Perazzini

et al. 2022

Front. Integr. Neurosci.

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The performance monitoring system is fundamentally important for adapting one’s own behavior in conflicting and error-prone, highly demanding circumstances. Flexible behavior requires that neuronal populations optimize information processing through efficient multi-scale communication. Non-invasive brain stimulation (NIBS) studies using transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES) fields to alter the cortical activity promise to illuminate the neurophysiological mechanisms that underpin neuro-cognitive and behavioral processing and their causal relationship. Here, we focus on the transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) that have been increasingly used in cognitive neuroscience for modulating superficial neural networks in a polarity (tDCS) and frequency/phase (tACS) fashion. Specifically, we discuss recent evidence showing how tDCS and tACS modulate the performance monitoring network in neurotypical samples. Emphasis is given to studies using behavioral tasks tapping conflict and error processing such as the Stroop, the Flanker, and the Simon tasks. The crucial role of mid-frontal brain regions (such as the medial frontal cortex, MFC; and the dorsal anterior cingulate cortex, dACC) and of theta synchronization in monitoring conflict and error is highlighted. We also discuss current technological limitations (e.g., spatial resolution) and the specific methodological strategies needed to properly modulate the cortical and subcortical regions.

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“…The dorsal ACC (dACC), also labeled the midcingulate cortex (MCC; Stevens et al, 2011 ), is connected to the dlPFC, supplementary motor area (SMA), supramarginal gyrus, and insula revealing its involvement in social cognitive and motor processes ( Overbeek et al, 2021 ; Tuovinen et al, 2022 ). The MCC was found to mediate decision making, executive control ( Mattavelli et al, 2022 ), and emotion regulation ( Li et al, 2014 ) with increased activation in the anterior MCC being associated with decreased negative emotion ( Stevens et al, 2011 ). Increased ACC activity during a task has been associated with improved emotion regulation ( Tang et al, 2016 ).…”

Section: Structure and Function Of Neural Regions That May Be Connect...mentioning

confidence: 99%

The neurobiology of misophonia and implications for novel, neuroscience-driven interventions

et al. 2022

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Decreased tolerance in response to specific every-day sounds (misophonia) is a serious, debilitating disorder that is gaining rapid recognition within the mental health community. Emerging research findings suggest that misophonia may have a unique neural signature. Specifically, when examining responses to misophonic trigger sounds, differences emerge at a physiological and neural level from potentially overlapping psychopathologies. While these findings are preliminary and in need of replication, they support the hypothesis that misophonia is a unique disorder. In this theoretical paper, we begin by reviewing the candidate networks that may be at play in this complex disorder (e.g., regulatory, sensory, and auditory). We then summarize current neuroimaging findings in misophonia and present areas of overlap and divergence from other mental health disorders that are hypothesized to co-occur with misophonia (e.g., obsessive compulsive disorder). Future studies needed to further our understanding of the neuroscience of misophonia will also be discussed. Next, we introduce the potential of neurostimulation as a tool to treat neural dysfunction in misophonia. We describe how neurostimulation research has led to novel interventions in psychiatric disorders, targeting regions that may also be relevant to misophonia. The paper is concluded by presenting several options for how neurostimulation interventions for misophonia could be crafted.

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High-definition transcranial direct current stimulation of the dorsal anterior cingulate cortex modulates decision-making and executive control

Cited by 14 publications

References 105 publications

Cognition, body, and mind: A three‐in‐one coordinate‐based fMRI meta‐analysis on cognitive, physical, and meditative trainings

Cognition, body, and mind: A three‐in‐one coordinate‐based fMRI meta‐analysis on cognitive, physical, and meditative trainings

Neuromodulating the performance monitoring network during conflict and error processing in healthy populations: Insights from transcranial electric stimulation studies

The neurobiology of misophonia and implications for novel, neuroscience-driven interventions

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