High-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Cardiovascular Disease in United States Adults

Bilhorn, Kyle R.; Luo, Yunhua; Lee, Brian T.; Wong, Nathan D.

doi:10.1016/j.amjcard.2012.06.056

Cited by 23 publications

(16 citation statements)

References 16 publications

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“…It has been shown, however, that hs-CRP levels above 3 mg/L were associated with a decrease in the protective effect of HDL >0.6 g/L. 16 The decrease in ESR also appears clinically relevant. It has been shown that the incidence of carotid atherosclerotic plaques was significantly higher in the psoriasis group (as compared to control group) when inflammatory parameters, including ESR, were increased (34.7% vs. 8.2%, P = 0.001).…”

Section: Discussionmentioning

confidence: 99%

Impact of systemic treatment of psoriasis on inflammatory parameters and markers of comorbidities and cardiovascular risk: results of a prospective longitudinal observational study

Montaudié¹,

Albert-Sabonnadière²,

Acquacalda³

et al. 2013

Acad Dermatol Venereol

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We observed a high frequency of disturbance of inflammatory parameters and markers of comorbidities and CV risk in a population with moderate to severe PsO and PsA, most of which were not detected before. A significant decrease in inflammatory parameters was noted after the introduction of systemic therapy, while other parameters remained unaffected by the treatment, except the weight that increased under biologics therapies.

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Section: Discussionmentioning

confidence: 99%

Impact of systemic treatment of psoriasis on inflammatory parameters and markers of comorbidities and cardiovascular risk: results of a prospective longitudinal observational study

Montaudié¹,

Albert-Sabonnadière²,

Acquacalda³

et al. 2013

Acad Dermatol Venereol

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“…C-reactive protein (CRP) is a circulatory acute phase reactant produced mainly in the liver, but smooth muscle cells of coronary arteries also make this substance. In addition to its role in pathogenesis of CVDs mostly due to initiation and development of atherosclerotic lesions and causing insulin resistance and type 2 DM, this protein enhances the likelihood of plaque rupture [9][10][11][12]. High sensitivity method are used to measure this acute phase reactant protein, which introduced a novel biomarker named high sensitivity CRP (hs-CRP).…”

Section: Introductionmentioning

confidence: 99%

High Sensitivity C-Reactive Protein Predictive Value for Cardiovascular Disease: A Nested Case Control from Isfahan Cohort Study (ICS)

Koosha

Roohafza

Sarrafzadegan

et al. 2020

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“…3-7 Lipoprotein-associated phospholipase A2 (Lp-PLA 2 ), a proatherogenic inflammatory marker, has also been shown to be associated with risk for CHD, independent of traditional cardiovascular risk factors. 8 We recently demonstrated in US adults from the cross-sectional National Health and Nutrition Examination Survey that CRP levels > 3 mg/L are associated with a greater prevalence of CHD at all levels of HDL-C. 9 …”

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confidence: 99%

Impact of inflammatory biomarkers on relation of high density lipoprotein-cholesterol with incident coronary heart disease: Cardiovascular Health Study

et al. 2013

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Background Inflammatory factors and low HDL-C relate to CHD risk, but whether inflammation attenuates any protective association of high HDL-C is unknown. Objective Investigate inflammatory markers' individual and collective impact on the association of HDL-C with incident coronary heart disease (CHD). Methods In 3,888 older adults without known cardiovascular disease (CVD), we examined if the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and lipoprotein-associated phospholipase A2 (Lp-PLA2) modify the relation of HDL-C with CHD. HDL-C, CRP, IL-6, and Lp-PLA2 values were grouped as using gender-specific tertiles. Also, an inflammation index of z-score sums for CRP, IL-6, and Lp-PLA2 was categorized into tertiles. We calculated CHD incidence for each HDL-C/inflammation group and performed Cox regression, adjusted for standard CVD risk factors and triglycerides to examine the relationship of combined HDL-C-inflammation groups with incident events. Results CHD incidence (per 1,000 person years) was higher for higher levels of CRP, IL-6, and the index, and lower for higher levels of HDL-C. Compared to high HDL-C/low-inflammation categories (referent), adjusted HRs for incident CHD were increased for those with high HDL-C and high CRP (HR=1.50, p<0.01) or highest IL-6 tertile (HR=1.40, p<0.05), but not with highest Lp-PLA2 tertile. Higher CHD incidence was similarly seen for those with intermediate or low HDL-C accompanied by high CRP, high IL-6, or a high inflammatory index. Conclusion The protective relation of high HDL-C for incident CHD appears to be attenuated by greater inflammation.

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High-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Cardiovascular Disease in United States Adults

Cited by 23 publications

References 16 publications

Impact of systemic treatment of psoriasis on inflammatory parameters and markers of comorbidities and cardiovascular risk: results of a prospective longitudinal observational study

Impact of systemic treatment of psoriasis on inflammatory parameters and markers of comorbidities and cardiovascular risk: results of a prospective longitudinal observational study

High Sensitivity C-Reactive Protein Predictive Value for Cardiovascular Disease: A Nested Case Control from Isfahan Cohort Study (ICS)

Impact of inflammatory biomarkers on relation of high density lipoprotein-cholesterol with incident coronary heart disease: Cardiovascular Health Study

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