High density lipoprotein subfractions and paraoxonase 1 in children

Muchová, Jana; Andrezálová, Lucia; Oravec, Stanislav; Nagyová, Zuzana; Garaiová, Iveta; Ďuračková, Zdeňka

doi:10.18388/abp.2015_1230

Cited by 10 publications

(18 citation statements)

References 46 publications

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“…Moreover, smaller HDL size and/or increased proportion of HDL 3 particles were associated with reduced PON1 activity . The associations between HDL‐cholesterol level and size heterogeneity, and PON1 activity and/or markers of inflammation observed in our studies were subsequently confirmed by several research groups while denied by others . A possible explanation for inconsistent data could have been attributed to different methodological approaches used to isolate HDL subclasses, disparities in substrates employed for PON1 activity determination and differences in the characteristics of study participants.…”

Section: Hdl Characteristics and Pon1 Activity—a Bridge Toward Hdl Fumentioning

confidence: 48%

“…28,29,32 The associations between HDL-cholesterol level and size heterogeneity, and PON1 activity and/or markers of inflammation observed in our studies were subsequently confirmed by several research groups [33][34][35] while denied by others. 36,37 A possible explanation for inconsistent data could have been attributed to different methodological approaches used to isolate HDL subclasses, disparities in substrates employed for PON1 activity determination and differences in the characteristics of study participants. Our data provided valuable information on the clinical significance of the advanced lipid profile and oxidative stress testing and its modulation in high-risk subjects.…”

Section: Hdl Characteristics and Pon1 Activity-a Bridge Toward Hdl mentioning

confidence: 99%

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Paraoxonase 1 and atherosclerosis‐related diseases

et al. 2019

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A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high‐density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti‐inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis‐related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end‐stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features.

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Section: Hdl Characteristics and Pon1 Activity—a Bridge Toward Hdl Fumentioning

confidence: 48%

Section: Hdl Characteristics and Pon1 Activity-a Bridge Toward Hdl mentioning

confidence: 99%

Paraoxonase 1 and atherosclerosis‐related diseases

et al. 2019

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“…Moreover, a longer FA embedded in the membrane (e.g. DHA) contributes to the increased size of lipoprotein particles LDL and HDL characterized by an atheroprotective effect (Oravec et al 2011, Muchová et al 2016. In addition to the composition of FA, membrane fluidity is influenced also by other factors, e.g.…”

Section: Why Are Omega-3 Fas Important For Physical and Mental Health?mentioning

confidence: 99%

Cardiovascular Diseases, Depression Disorders and Potential Effects of Omega-3 Fatty Acids

et al. 2017

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Cardiovascular disease (CVD) and depressive disorders (DD) are two of the most prevalent health problems in the world. Although CVD and depression have different origin, they share some common pathophysiological characteristics and risk factors, such as the increased production of proinflammatory cytokines, endothelial dysfunction, blood flow abnormalities, decreased glucose metabolism, elevated plasma homocysteine levels, oxidative stress and disorder in vitamin D metabolism. Current findings confirm the common underlying factors for both pathologies, which are related to dramatic dietary changes in the mid-19th century. By changing dietary ratio of omega-6 to omega-3 fatty acids from 1:1 to 15-20:1 some changes in metabolism were induced, such as increased pro-inflammatory mediators and modulations of different signaling pathways following pathophysiological response related to both, cardiovascular diseases and depressive disorders.

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“…Oravec et al (2011) [ 20 ] consider intermediate HDL (I-HDL4-7) subfractions as anti-atherogenic part of HDL family. Based on our previous results, we hypothesize that I-HDL4 and I-HDL-5, which are adjacent to large HDL subfractions, are rather non-atherogenic and I-HDL6 a 7, which are adjacent to small HDL subfractions are rather atherogenic [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…No significant association between PON1-A and the HDL subfractions in 27 mildly hypercholesterolemic children was found. In contrast, PON1-L activity positively correlated with the antiatherogenic large HDL1 subfraction and negatively with intermediate HDL subfractions 4, 5, and 6 [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Lipid Profile, Lipoprotein Subfractions, and Fluidity of Membranes in Children and Adolescents with Depressive Disorder: Effect of Omega-3 Fatty Acids in a Double-Blind Randomized Controlled Study

et al. 2020

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Depressive disorder (DD) is a psychiatric disorder whose molecular basis is not fully understood. It is assumed that reduced consumption of fish and omega-3 fatty acids (FA) is associated with DD. Other lipids such as total cholesterol (TCH), LDL-, and HDL-cholesterols (LDL-CH, HDL-CH) also play a role in depression. The primary endpoint of the study was the effect of omega-3 FA on the severity of depression in children and adolescents. This study aimed to investigate the secondary endpoint, relationship between depressive disorder symptoms and lipid profile, LDL- and HDL-cholesterol subfractions, Paraoxonase 1 (PON1) activities, and erythrocyte membrane fluidity in 58 depressed children and adolescents (calculated by the statistical program on the effect size), as well as the effect of omega-3 FA on the monitored parameters. Depressive symptoms were assessed by the Children’s Depression Inventory (CDI), lipid profile by standard biochemical procedures, and LDL- and HDL-subfractions by the Lipoprint system. Basic biochemical parameters including lipid profile were compared with levels in 20 healthy children and were in the physiological range. Improvement of symptoms in the group supplemented with a fish oil emulsion rich in omega-3 FA in contrast to omega-6 FA (emulsion of sunflower oil) has been observed. We are the first to report that omega-3 FAs, but not omega-6 FA, increase large HDL subfractions (anti-atherogenic) after 12 weeks of supplementation and decrease small HDL subfractions (proatherogenic) in depressed children. We found a negative correlation between CDI score and HDL-CH and the large HDL subfraction, but not LDL-CH subfractions. CDI score was not associated with erythrocyte membrane fluidity. Our results suggest that HDL-CH and its subfractions, but not LDL-CH may play a role in the pathophysiology of depressive disorder. The study was registered under ISRCTN81655012.

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High density lipoprotein subfractions and paraoxonase 1 in children

Cited by 10 publications

References 46 publications

Paraoxonase 1 and atherosclerosis‐related diseases

Paraoxonase 1 and atherosclerosis‐related diseases

Cardiovascular Diseases, Depression Disorders and Potential Effects of Omega-3 Fatty Acids

Lipid Profile, Lipoprotein Subfractions, and Fluidity of Membranes in Children and Adolescents with Depressive Disorder: Effect of Omega-3 Fatty Acids in a Double-Blind Randomized Controlled Study

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