High-density theta oscillatory-modulated tDCS (theta HD-otDCS) over the parietal cortex for targeted memory enhancement

Abstract

Associative memory (AM) is a memory domain vital for normal cognitive functioning. It declines over time due to healthy aging as well as in various neurological conditions. Standard transcranial electrical stimulation (tES) protocols show inconclusive facilitatory effects on AM, often lacking function specificity and stimulation focality. We tested the effectiveness of high-density electrode montage delivering anodal theta oscillatory-modulated transcranial direct current stimulation (HD-Theta-otDCS) over the left posterior parietal cortex (PPC), aiming to target AM in a spatially focused and function-specific manner. In a sham-controlled cross-over experiment, we explored the differential effects of HD-Theta-otDCS applied during either encoding or the retrieval phases of two AM tasks (Face-Word and Object-Location). The stimulation protocol consisted of an anode over the left PPC (P3) and four surrounding return electrodes (CP1, CP5, PO3, POz) with electrical current oscillating in theta rhythm (5Hz, 1.5 ± 0.5mA). HD-Theta-otDCS stimulation applied during both encoding (p=0.020, ηp2=0.22) and retrieval (p=0.005, ηp2=0.32) increased AM performance compared to sham control in the Face-Word task. We found no differences between the two active stimulation conditions. HD-Theta-otDCS showed to be a promising tool for enhancing AM, regardless of the stimulation timing. The results provide further support for our previous findings with bipolar otDCS and confirm that PPC stimulation can induce behaviorally relevant modulation in the memory-related cortico-subcortical networks. Significance: The presented approach is one step forward towards precision brain stimulation for memory neuromodulation. The novelty lies in the combination of increased focality and function-specific current waveform. Positive results set the ground for further research on HD-theta-otDCS effectiveness on clinical samples.