High Dietary Magnesium Intake  is Significantly and Independently Associated with Higher Insulin Sensitivity in a Mexican-Mestizo Population: A Brief Cross-Sectional Report

Moctezuma‐Velázquez, Carlos; Gómez-Sámano, Miguel Ángel; Cajas-Sánchez, María Belen; Reyes-Molina, Diana Lorena; Galindo-Guzmán, Mariana; Meza-Arana, Clara Elena; Cuevas‐Ramos, Daniel; Gómez-Pérez, Francisco J.; Gulı́as-Herrero, Alfonso

doi:10.24875/ric.17002086

Cited by 8 publications

(8 citation statements)

References 28 publications

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“…This is consistent with the Dietary Reference Intakes (DRI) from the French Food Safety Agency, which recommended 6 mg/kg body weight of Mg intake per day. 28 A study from the United States also demonstrated that the dietary Mg intake requirement, which was 2.36 mg/kg per day, was related to body weight. 29 More studies are necessary to confirm whether weight-adjusted Mg intake is a better indicator for Mg intake.…”

Section: Discussionmentioning

confidence: 98%

<p>Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population</p>

Yang

et al. 2020

DMSO

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Purpose: High dietary magnesium intake may reduce insulin resistance (IR) and metabolic syndrome (MetS). The aim of the cross-sectional analysis was to evaluate the association between dietary magnesium intake, IR, and MetS using data from China Health and Nutrition Survey. Methods: Dietary magnesium intake was defined as daily dietary magnesium intake divided by body weight. Logistic regression analysis was used to calculate the odds ratio (OR) for IR and the prevalence of MetS across the quartile categories of dietary magnesium intake. In addition, we used the macro PROCESS to perform the mediation analyses. Results: A total of 8120 participants were included in the final analysis. We found a significant negative association between dietary magnesium intake and IR, the multivariable-adjusted OR for HOMA-IR comparing the highest to the lowest quartile of dietary magnesium intake was 0.435 (95% confidence intervals [CI] 0.376 to 0.502). The prevalence of the MetS was 38.6%, 28.9%, 22.5%, and 16.5% for increasing quartiles of dietary magnesium intake (p <0.001). The mediation model analysis displayed that insulin resistance mediated the effect of dietary magnesium on MetS. The direct effect and indirect effect of dietary magnesium on MetS were found significant, and the calculated percentage of mediation by insulin resistance was 19.6%. Conclusion: Our study demonstrated a significant and independent negative relationship among weight-adjusted dietary magnesium intake, HOMA-IR, and MetS in a large Chinese population. IR partly mediated the relationship between dietary magnesium intake and MetS.

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Section: Discussionmentioning

confidence: 98%

<p>Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population</p>

Yang

et al. 2020

DMSO

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“…Yu et al also showed an association between magnesium levels and HD patients’ responses to ESAs [ 23 ]. Previous studies have also suggested that improvements in insulin sensitivity, serum albumin levels, endothelial function, and the energy metabolism of erythrocytes may contribute to improvements in the responsiveness of ESAs via magnesium [ 24 , 25 , 26 ]. Our study did not include data on micronutrients.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Patient Survival According to Erythropoiesis-Stimulating Agent Type of Treatment in Maintenance Hemodialysis Patients

Kang

Kim

Son

et al. 2023

JCM

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This study aimed to evaluate the difference in patient survival according to the type of erythropoiesis-stimulating agent (ESA) treatment used in the Korean hemodialysis (HD) population. This retrospective study analyzed the laboratory data from a national HD quality assessment program and the claims of Korea. Included participants were divided into three groups according to the type of ESA used during the 6 months of each assessment period as follows: the EP group (n = 38,043, epoetin-α or epoetin-β), the DP group (n = 10,054, darbepoetin-α), and the MR group (2253, continuous erythropoietin receptor activator). The ESA doses in the EP, DP, and MR groups were 6451 ± 3586, 5959 ± 3857, and 3877 ± 2275 unit/week, respectively. The erythropoiesis resistance indexes (ERIs) in the three groups were 10.7 ± 6.7, 9.9 ± 7.6, and 6.3 ± 4.1 IU/kg/g/dL, respectively. Kaplan–Meier curves revealed similar rates of patient survival among the three groups (p = 0.530). A multivariate Cox regression analysis showed that the hazard ratios in the DP group and MR group were 1.00 (p = 0.853) and 0.87 (p < 0.001), respectively, compared to that of the EP group. The hazard ratio in the MR group was 0.87 (p = 0.001) compared to that of the DP group. Our study shows that the MR group had comparable or better patient survival than the EP and DP groups in the multivariate analysis. However, the ESA doses and ERI were considerably different among the three groups. It was difficult to determine whether the better patient survival in the MR group originated from the ESA type, ESA dose, ERI, or other hidden factors.

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“…Then, we decided to adjust the dietary Mg intake by body weight, and we found a significant association before and after the three-model adjustment. A study from Mexico also chose to adjust the Mg intake by body weight and found a significant result showing that the insulin sensitivity assessed by the Matsuda index was higher in the high dietary Mg intake group; however, the sample size of the study was small [26]. Given that the previous studies, which did not show a statistically significant correlation between dietary Mg intake and insulin resistance all used total dietary Mg intake instead of weight-adjusted dietary Mg intake, we assumed that the amount of dietary Mg an individual needed was related to his/her weight.…”

Section: Discussionmentioning

confidence: 99%

Reduced insulin resistance partly mediated the association of high dietary magnesium intake with less metabolic syndrome in a large Chinese population

Yang

et al. 2020

Preprint

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Background High dietary magnesium intake may reduce insulin resistance (IR) and metabolic syndrome (MetS). However, previous studies were inconsistent in Asian population and there have been no study about the mediation of IR in the relationship between dietary magnesium intake and MetS. Thus, this cross-sectional analysis aimed to evaluate the association between dietary magnesium intake, IR and MetS using data from China Health and Nutrition Survey. Methods Dietary magnesium intake was defined as daily dietary magnesium intake divided by body weight. Logistic regression analysis was used to calculate the odds ratio (OR) for IRand the prevalence of MetS across the quartile categories of dietary magnesium intake. Results 8,254 participants were included in final analysis. We found a significant negative association between dietary magnesium intake and IR, the multivariable-adjusted OR for HOMA-IR comparing the highest to the lowest quartile of dietary magnesium intake was 0.435 (95% confidence intervals (CI) 0.376 to 0.502). The prevalence of the MetS was 33.5%, 24.9%, 18.4% and 13.4% for increasing quartiles of dietary magnesium intake (p <0.001). The direct effect and indirect effect of dietary magnesium on MetS was found significant, and the calculated percentage of mediation was 23.0%. Conclusion Our study demonstrated a significant and independent negative relationship among weight adjusted dietary magnesium intake, HOMA-IR and MetS in a large Chinese population. IR partly mediated the relationship between dietary magnesium intake and MetS.Keywords: diet magnesium intake; metabolic syndrome; insulin resistance; Chinese population; mediation effect

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High Dietary Magnesium Intake is Significantly and Independently Associated with Higher Insulin Sensitivity in a Mexican-Mestizo Population: A Brief Cross-Sectional Report

Abstract: background: Magnesium acts as a cofactor in many intracellular reactions including phosphorylation of the insulin receptor;

Cited by 8 publications

References 28 publications

<p>Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population</p>

<p>Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population</p>

Comparison of Patient Survival According to Erythropoiesis-Stimulating Agent Type of Treatment in Maintenance Hemodialysis Patients

Reduced insulin resistance partly mediated the association of high dietary magnesium intake with less metabolic syndrome in a large Chinese population

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