High-Dose 8% Capsaicin Patch in Treatment of Chemotherapy-Induced Peripheral Neuropathy. A Systematic Review

Cabezón-Gutiérrez, Luis; Custodio-Cabello, Sara; Palka-Kotlowska, Magda; Khosravi-Shahi, Parham

doi:10.1016/j.jpainsymman.2020.06.026

Cited by 13 publications

(8 citation statements)

References 31 publications

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“…In migraine, several agents targeting TRPA-1 and TRPV-1 receptors can trigger or preempt headache attacks. The high-concentration (8%) capsaicin patch is strongly recommended for the treatment of peripheral NPs such as PDN, PHN, and HIV-neuropathy [ 88 , 89 ]. Early-phase clinical trials are ongoing both for migraine and NPs.…”

Section: Transient Receptor Potential Ion Channel Function In Migrain...mentioning

confidence: 99%

Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain

Tajti

Delia

Csáti

et al. 2023

IJMS

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Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which exhibit some symptom similarities and are thus considered to share a common etiology. The calcitonin gene-related peptide (CGRP) has gained credit as a target for migraine management; nevertheless, the efficacy and the applicability of CGRP modifiers warrant the search for more effective therapeutic targets for pain management. This scoping review focuses on human studies of common pathogenic factors in migraine and NP, with reference to available preclinical evidence to explore potential novel therapeutic targets. CGRP inhibitors and monoclonal antibodies alleviate inflammation in the meninges; targeting transient receptor potential (TRP) ion channels may help prevent the release of nociceptive substances, and modifying the endocannabinoid system may open a path toward discovery of novel analgesics. There may exist a potential target in the tryptophan-kynurenine (KYN) metabolic system, which is closely linked to glutamate-induced hyperexcitability; alleviating neuroinflammation may complement a pain-relieving armamentarium, and modifying microglial excitation, which is observed in both conditions, may be a possible approach. Those are several potential analgesic targets which deserve to be explored in search of novel analgesics; however, much evidence remains missing. This review highlights the need for more studies on CGRP modifiers for subtypes, the discovery of TRP and endocannabinoid modulators, knowledge of the status of KYN metabolites, the consensus on cytokines and sampling, and biomarkers for microglial function, in search of innovative pain management methods for migraine and NP.

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Section: Transient Receptor Potential Ion Channel Function In Migrain...mentioning

confidence: 99%

Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain

Tajti

Delia

Csáti

et al. 2023

IJMS

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“…In einem systematischen Review kommen Cabezón-Gutiérrez et al zu dem Schluss, dass 8 %iges Capsaicin zu einer signifikanten Schmerzlinderung bei PatientInnen mit CIPN führt. Die Autoren kritisieren allerdings die geringe Anzahl an geeigneten Studien [46].…”

Section: Nutzenunclassified

Nutzen und Wirtschaftlichkeit der Topischen Behandlung Peripherer Neuropathischer Schmerzen mit dem Capsaicin-Pflaster Qutenza – ein Literaturüberblick

Thiem

Kunde

Quandel

et al. 2022

Gesundheitsökonomie & Qualitätsmanagement

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Zusammenfassung Hintergrund Periphere Neuropathien sind häufig und beeinträchtigen die Lebensqualität der PatientInnen erheblich. Die Behandlung ist komplex und kann, in Abhängigkeit von der Grunderkrankung, bei vielen PatientInnen keine vollständige Beschwerdefreiheit erzielen. Eine Therapieoption ist hochdosiertes Capsaicin 179 mg (oder 8%) in Form eines kutanen Pflasters (Qutenza). Die vorliegende Literaturübersicht soll eine Einschätzung zu Nutzen und Kosten dieser Therapie, auch im Vergleich zu systemischer Medikation, bieten. Methodik In der bibliografischen Datenbank PubMed wurde eine strukturierte Literaturrecherche durchgeführt, um relevante Publikationen zur topischen Therapie peripherer neuropathischer Schmerzen mit dem hochdosierten Capsaicin-Pflaster zu identifizieren und hinsichtlich ihres Nutzens sowie unter ökonomischen Gesichtspunkten zu bewerten. Die Ergebnisse der eingeschlossenen Publikationen wurden extrahiert und narrativ zusammengefasst. Ergebnisse Es wurden insgesamt 29 Artikel in die Auswertung einbezogen. In acht randomisierten kontrollierten Studien konnte die Wirksamkeit einer Behandlung peripherer neuropathischer Schmerzen unterschiedlicher Genese mit hochdosiertem Capsaicin in Form eines kutanen Pflasters belegt werden. Das Capsaicin-Pflaster führte gegenüber der Standard-Therapie zu einer vergleichbaren Reduktion der neuropathischen Schmerzsymptome bei deutlich geringeren Nebenwirkungen. Für den Bereich der Wirtschaftlichkeit konnten nur drei Publikationen ermittelt werden, die jedoch nicht das deutsche Gesundheitssystem berücksichtigen. Die drei Analysen kommen zu dem Schluss, dass die topische Capsaicin-Therapie im Vergleich zu den jeweils untersuchten systemisch wirksamen Vergleichspräparaten kosteneffektiv ist. Schlussfolgerung Es konnte für periphere neuropathische Schmerzen unterschiedlicher Genese der Nutzen einer topischen Behandlung mit dem kutanen Capsaicin-Pflaster Qutenza nachgewiesen werden. In Bezug auf die Wirtschaftlichkeit dieser Therapieoption, besonders in Hinblick auf das deutsche Gesundheitssystem, sind weitere Analysen notwendig.

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“…Meanwhile, the subpopulation of NK-1R+ cells possibly correlated to impaired STAT3 phosphorylation and neuroendocrine cell maintenance ( 33 ). Interestingly, capsaicin purified from the pepper plant has a dose-dependent effect on its target TRPV1; the appropriate dose of capsaicin binds to TRPV1 and activates sensory nerves with the release of SP and CGRP, whereas an accumulating dose of capsaicin could achieve capsaicin desensitization which reversibly or permanently silences whole neurons for the treatment proposed ( 69 , 70 ). According to these mechanisms, the application of TRPV1 antagonist (AG1529 has a partially inhibitory effect) has been approved to prevent the transition from acute pancreatitis to chronic pancreatitis (CP), along with the development of CP and inflammation-related pain in a murine model ( 71 , 72 ).…”

Section: Nerve Innervation In Pdacmentioning

confidence: 99%

The connection between innervation and metabolic rearrangements in pancreatic cancer through serine

et al. 2022

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Pancreatic cancer is a kind of aggressive tumor famous for its lethality and intractability, and pancreatic ductal adenocarcinoma is the most common type. Patients with pancreatic cancer often suffer a rapid loss of weight and abdominal neuropathic pain in their early stages and then go through cachexia in the advanced stage. These features of patients are considered to be related to metabolic reprogramming of pancreatic cancer and abundant nerve innervation responsible for the pain. With increasing literature certifying the relationship between nerves and pancreatic ductal adenocarcinoma (PDAC), more evidence point out that innervation’s role is not limited to neuropathic pain but explore its anti/pro-tumor functions in PDAC, especially the neural–metabolic crosstalks. This review aims to unite pancreatic cancer’s innervation and metabolic rearrangements with terminated published articles. Hopefully, this article could explore the pathogenesis of PDAC and further promote promising detecting or therapeutic measurements for PDAC according to the lavish innervation in PDAC.

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High-Dose 8% Capsaicin Patch in Treatment of Chemotherapy-Induced Peripheral Neuropathy. A Systematic Review

Cited by 13 publications

References 31 publications

Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain

Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain

Nutzen und Wirtschaftlichkeit der Topischen Behandlung Peripherer Neuropathischer Schmerzen mit dem Capsaicin-Pflaster Qutenza – ein Literaturüberblick

The connection between innervation and metabolic rearrangements in pancreatic cancer through serine

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