High Dose Cabergoline in Management of Bilateral Ovarian Hyperstimulation Syndrome: A Case Report

Abstract

Ovarian hyperstimulation syndrome (OHSS) is an exaggerated response to excess hormones and is also one of the life-threatening iatrogenic complications which is associated with ovulation induction. This syndrome usually occurs in women who receive injectable hormones for the stimulation of egg development in the ovaries. This study describes a rare case of moderate ovarian hyperstimulation syndrome which has been managed and treated with high-dose cabergoline. The patient was diagnosed in the Medical Imaging and Radiation Sciences Department of Kabul University of Medical Sciences and treated in Shahrara Teaching Hospital. A 26-year-old woman was diagnosed with the development of bilateral moderate ovarian hyperstimulation syndrome after receiving clomiphene citrate in dose of 100 mg BID on day 5 of period and Human Chorionic Gonadotropin (HCG) 10,000 units for egg release on day 14 of period. The patient was given a high dose of cabergoline. The dose was adjusted to 1 mg/day for eight days since she was diagnosed with ovarian hyperstimulation syndrome. Consequently, the main outcome of our intervention was complete resolution of OHSS as well as complete recovery of the patient. As a result, it is concluded that the high dose of cabergoline prevents and reduces the occurrence, prolongation, and severity of ovarian hyperstimulation syndrome. However, more assessments through randomized controlled trials regarding the efficacy and safety of cabergoline doses and treatment duration for treatment and preventive purposes are required.

Cabergolina en El Tratamiento Del Síndrome De Hiperestimulación Ovárica: Una Revisión Actualizada.

“…Además, la cabergolina ha demostrado ser efectiva en la prevención del SHO en pacientes con síndrome de ovario poliquístico (SOP), un grupo de alto riesgo para el desarrollo de esta complicación (8). Estudios han reportado una reducción significativa en la incidencia de SHO en mujeres con SOP tratadas con cabergolina en comparación con aquellas que no recibieron tratamiento preventivo (8,9).…”

Adnexal Torsion Associated With Recurrent Ovarian Hyperstimulation Syndrome: A Case Report

“…In high-risk cases, preventive measures such as cabergoline, prophylactic albumin or high-protein diet, metformin, low-dose aspirin, and relcovaptan among other strategies can be adopted to reduce the incidence of OHSS [ 11 ]. This patient had been managed with cabergoline after her diagnosis of OHSS, the effectiveness of which is described in several studies including randomized controlled trials and case reports [ 12 , 13 ].…”