High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma

Haveman, Lianne M.; Ewijk, Roelof van; Dalen, Elvira C. van; Breunis, Willemijn B.; Kremer, Leontien C. M.; Berg, Henk van den; Dirksen, Uta; Merks, Johannes H. M.

doi:10.1002/14651858.cd011406.pub2

Cited by 5 publications

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References 51 publications

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“…El tratamiento de la recurrencia y de la enfermedad metastásica sigue siendo un desafío, ya que en los últimos 30 años no ha habido grandes avances en la supervivencia de estos pacientes. Uno de los tratamientos utilizados en las recidivas tumorales de sarcoma de Ewing es la QT a altas dosis y el posterior trasplante autólogo de células hematopoyéticas, pero no hay suficiente evidencia sobre su superioridad respecto al tratamiento estándar (QT) 74 (Figura 3).…”

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Utilidad de los estudios genómicos basados en paneles de NGS (Next Generation Sequencing) para el manejo clínico de los sarcomas en pacientes pediátricos

Gutiérrez

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Clinical managem ent of sarcomas is complex because th ey are rare a.nd heterogeneous tumo rs. Management requires a coord inated multidiscip linary approach, especially in children. Genomic ch aracterization of this complex group of tumors con tributes to the identification of progn ostic biomarkers and to the continued exp ansion of therapeutic options. In this article, we p resen t the positive experience of two Spanish hospitals in the use of gen omic analysis in the overall clinical management of sarcomas in children and young adults. We describe on a case-by-case basis h ow gen omic analysis h as con tribu ted to both diagnosis an d treatm en t.

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Section: Tratamientounclassified

Utilidad de los estudios genómicos basados en paneles de NGS (Next Generation Sequencing) para el manejo clínico de los sarcomas en pacientes pediátricos

Gutiérrez

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High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma

Haveman

Ewijk

Dalen

et al. 2021

Cochrane Database of Systematic Reviews

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UK guidelines for the management of bone sarcomas

Gerrand,

Amary,

Anwar

et al. 2024

Br J Cancer

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This document is an update of the British Sarcoma Group guidelines (2016) and provides a reference standard for the clinical care of UK patients with primary malignant bone tumours (PMBT) and giant cell tumours (GCTB) of bone. The guidelines recommend treatments that are effective and should be available in the UK, and support decisions about management and service delivery. The document represents a consensus amongst British Sarcoma Group members in 2024. Key recommendations are that bone pain, or a palpable mass should always lead to further investigation and that patients with clinical or radiological findings suggestive of a primary bone tumour at any anatomic site should be referred to a specialist centre and managed by an accredited bone sarcoma multidisciplinary team. Treatment recommendations are provided for the major tumour types and for localised, metastatic and recurrent disease. Follow-up schedules are suggested.

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High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma

Abstract: High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma

Cited by 5 publications

References 51 publications

Utilidad de los estudios genómicos basados en paneles de NGS (Next Generation Sequencing) para el manejo clínico de los sarcomas en pacientes pediátricos

Utilidad de los estudios genómicos basados en paneles de NGS (Next Generation Sequencing) para el manejo clínico de los sarcomas en pacientes pediátricos

High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma

UK guidelines for the management of bone sarcomas

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