High-Dose Conjugated Estrogens do not Reduce Antithrombin III Activity in Tall Girls

W, von Petrykowski; Schmidt, Bernard

doi:10.1055/s-2007-1018741

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Further studies on the influence of oral contraceptives on coagulation confirm an increase of coagulation factors II, VII, IX, X, XII, of fibrinogen, protein C, and plasminogen, as well as a decrease of antithrombin III and of protein S 1634 35 Petrykowski and Schmidt7observed no decrease of antithrombin III during tall stature treatment with 7.5 mg conjugated oestrogens, and suggested that the conjugated nature of the oestrogen preparation accounted for this effect. Deficiency of antithrombin III is known to be associated with an increased risk of thrombosis 7…”

Section: Discussionmentioning

confidence: 92%

Oestrogen treatment of constitutional tall stature: a risk-benefit ratio

Weimann

Bergmann

Böhles

1998

Archives of Disease in Childhood

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Oestrogens are given in high doses for the treatment of tall stature in girls. The aim of this study was to obtain data considering eYciency, side eVects, and acceptance of the treatment of 50 constitutionally tall girls treated with conjugated oestrogens (7.5-11.25 mg/day). The mean (SD) adult height predictions were 188.3 (4.4) cm and the achieved height was 5.2 (3.3) cm less than the predicted height. A greater reduction from final predicted height occurred when treatment was started at an early bone age (<13.0 years) and with a remaining growth potential of greater than 10 cm. Even postmenarcheal girls, however, had a mean reduction of 4.8 (3.2) cm. The main side eVects were considerable weight gain (>10 kg), an increase in triglyceride concentrations (37.5% of the patients), and increased platelet aggregation (60% of the patients). Altogether 84.6% of the patients were satisfied with the treatment and 15.4% regretted having had it.

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