High-dose density neoadjuvant chemotherapy in bulky IB cervical cancer

Oncological and pregnancy outcomes after high-dose density neoadjuvant chemotherapy and fertility-sparing surgery in cervical cancer

“…When the same NAC was used in IB bulky tumours followed by radical hysterectomy, the optimal response rate was 78.8% [5]. The optimal response rate in our fertility-sparing group of patients was only 60.7%.…”

“…It does not exist any paper about similar aged women with cervical cancer IB1 bigger than 2 cm. Mortality in node-negative patients with bulky tumour after NAC and standard radical hysterectomy is 8.6% [5].…”

“…We did not use adjuvant treatment in our patient group after trachelectomy, some kind of adjuvant treatment is usually used after NAC followed by radical hysterectomy when any risk factor is present [5]. Adjuvant chemotherapy after NAC followed by radical hysterectomy is indicated at our department in all lymph node negative patients that respond to NAC and have macroscopic residual disease [4,5].…”

“…Adjuvant chemotherapy after NAC followed by radical hysterectomy is indicated at our department in all lymph node negative patients that respond to NAC and have macroscopic residual disease [4,5]. In the future, adjuvant chemotherapy after NAC followed by trachelectomy in women with residual disease would reduce the number of recurrences [5].…”

“…Some centres use neoadjuvant chemotherapy (NAC) in "bulky" cervical cancer to downstage tumour before radical surgery. The response rate of NAC in advanced cervical cancer is between 60 and 95% [4][5][6]. NAC can decrease tumour volume before surgery, which enables the complete removal of the tumour with negative margins whilst Gynecologic Oncology 135 (2014) 213-216 …”