High‐dose nifuratel for simple and mixed aerobic vaginitis: A single‐center prospective open‐label cohort study

Qian, Liang; Li, Nan; Song, Shuai; Zhang, Aihua; Li, Ni; Duan, Ying

doi:10.1111/jog.13052

Cited by 21 publications

(15 citation statements)

References 25 publications

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“…More specifically, thio‐substituted γ‐lactones have been demonstrated to show antiviral activity against poliovirus, RNA virus and herpes simplex virus type 1 (HSV‐1) (Figure , A and B ) . Also, this structure unit exists in the drugs, such as Nifuratel (Figure , C ), showing a broad antibacterial spectrum of action . Consequently, the synthesis of thio‐substituted γ‐lactones has received some attention in the past, but still remains largely underdeveloped…”

Section: Introductionmentioning

confidence: 99%

“…[3] Also, this structureu nit exists in the drugs,s uch as Nifuratel (Figure 1, C), showing ab road antibacterial spectrum of action. [4] Consequently,t he synthesis of thio-substituted g-lactones has received some attentioni nt he past, but stillr emains largely underdeveloped. [5] Unsaturated carboxylica cids represent attractive intermediates,w hich could serve to construct substituted lactone derivatives by functionalization of the C = Cd ouble bonda nd an intramolecular cyclization reaction.…”

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confidence: 99%

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Copper(II) Acetate‐Catalyzed Hydroxysulfenylation‐Initiated Lactonization of Unsaturated Carboxylic Acids with Oxygen as Oxidant and Oxygenation Reagent

Wang

Mei

et al. 2017

Adv Synth Catal

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Ac opper(II) acetate-catalyzed aerobic thiolation of C=Cd ouble bonds,o xygenation, and intramolecular cyclization reactions of unsaturated carboxylic acids with thiols has been explored. Ther eaction proceeds through an ew hydroxysulfenylationinitiated lactonization pathway with carboxyl as electrophilic group,w hich provides an efficient access to assembly highly valuable thio-substituted lactone derivatives with good yields under mild conditions.Several control experiments,a sw ella sa ni sotope label-ling experiment disclose that oxygen acts as both oxidant and reactant beingt ransferred into the final product.T he mechanistic studies support the discovery of an ew strategyt hrough difunctionalization of alkenes based on unsaturated carboxylic acids to construct the diversely substituted lactones.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Copper(II) Acetate‐Catalyzed Hydroxysulfenylation‐Initiated Lactonization of Unsaturated Carboxylic Acids with Oxygen as Oxidant and Oxygenation Reagent

Wang

Mei

et al. 2017

Adv Synth Catal

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“…Q. Liang и соавт. [15] при изучении исходного инфекционного статуса 142 пациенток с АВ обнаружили его в изолированном виде в 40,85% случаев, у остальных женщин он сочетался с БВ или с ВВК. Большинство рецидивирующих нарушений биоценоза влагалища связывают с БВ и применяют препараты метронидазола, которые не действуют на аэробные микроорганизмы.…”

Section: рис 1 факторы оказывающие влияние на вульвовагинальную экunclassified

A review of international and Russian scientific data on the use of polygynax for the treatment and prevention of patients with nonspecific (aerobic), vulvovaginal candidiasis, and mixed vaginitis

Кира¹,

Savicheva²

2018

Ross. vestn. akush.-ginekol.

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The paper gives an analytical review of the results of recent researches into the etiology, diagnosis, treatment, and prevention of infectious and inflammatory diseases of the vagina and vulva. The characteristic feature of inflammatory diseases of the lower genital tract is shown to be the predominance of mixed infections, and the formation of various bacterial and bacterial-fungal associations in the vaginal biotope (associations of gram-positive, gram-negative bacteria and fungi of the genus Candida) leads to a change in the clinical picture and to the paucisymptomatic forms of the disease, which complicate diagnosis and treatment. The paper states the basic requirements for a drug for the rational therapy of vaginal and vulvar infectious and inflammatory diseases of mixed bacterial and fungal etiologies, which should have a wide range of antimicrobial activity and a non-suppressive effect on the normal vaginal microflora (lactobacilli, bifidobacteria). Polygynax is a vaginal combination drug designed in France, which meets the above requirements in composition (neomycin sulfate 35 000 IU, polymyxin B sulfate 35,000 IU, and nystatin 100,000 IU in one capsule). The paper gives the results of original investigations by both Russian and foreign authors, which have shown the high efficacy of Polygynax in the treatment of both bacterial and fungal vaginitis. The efficacy of polygynax is of value not only against C. albicans strains, but also against C. non-albicans ones resistant to other drugs. The local use of the drug prevents the development of resistance of the pathological microflora. Polygynax does not inhibit the growth of the vaginal Lactobacillus microflora. It is the drug of choice in the local treatment of vaginitis, especially when treatment should be initiated before the results of microbiological examination are available.

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“…(25) Numerous clinical studies and systematic reviews based on meta-analysis present conflicting views on antimicrobial therapy for opportunistic infections of the vagina during pregnancy. (26)(27)(28)(29) The purpose of this study was to identify the relationship between the microbiological status of women and newborns, and the development of PL.…”

Section: Introductionmentioning

confidence: 99%

The Results of Microbiological Investigations into Preterm Labor

Оразмурадов¹,

Kostin²,

Apresyan³

et al. 2019

IJBM

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The purpose of this study was to identify the relationship between the microbiological status of women and newborns, and the development of premature labor. Materials and Methods: The study included 227 pregnant women at gestational age between 28 and 36 weeks and 6 days. All women underwent an assessment of vaginal microcenosis and the quantitative and qualitative composition of the biotope of the cervical discharge; the newborns underwent bacteriological examination of the auricle, pharynx and anus. Results: Disturbances in the vaginal biotope were diagnosed in every second woman. We found that the shorter the gestation period, the higher the frequency of disturbances in the vaginal biotope, and the risk of premature birth at an earlier time correlates with the presence of infection in the mother. The risk of giving birth to an infected child is 4.2 times higher at birth from a mother who has disturbances in the biotope, compared to a woman with a normal biotope.

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High‐dose nifuratel for simple and mixed aerobic vaginitis: A single‐center prospective open‐label cohort study

Abstract: Nifuratel 500 mg showed good clinical efficacy for the treatment of AV, particularly mixed AV, and is superior to the 250 mg dosage in the treatment of mixed AV.

Cited by 21 publications

References 25 publications

Copper(II) Acetate‐Catalyzed Hydroxysulfenylation‐Initiated Lactonization of Unsaturated Carboxylic Acids with Oxygen as Oxidant and Oxygenation Reagent

Copper(II) Acetate‐Catalyzed Hydroxysulfenylation‐Initiated Lactonization of Unsaturated Carboxylic Acids with Oxygen as Oxidant and Oxygenation Reagent

A review of international and Russian scientific data on the use of polygynax for the treatment and prevention of patients with nonspecific (aerobic), vulvovaginal candidiasis, and mixed vaginitis

The Results of Microbiological Investigations into Preterm Labor

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