High dose rate brachytherapy before external beam irradiation in inoperable oesophageal cancer

Taal, Babs G.; Aleman, B.M.P.; Koning, C. C. E.; Boot, H.

doi:10.1038/bjc.1996.564

Cited by 33 publications

(25 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…252 Addition of brachytherapy to external beam radiotherapy induces more rapid relief of dysphagia but with a risk of serious side effects including fistula formation. 253 It is also slower and less successful than either intubation or laser therapy.…”

Section: Palliative Radiotherapy or Chemotherapy As Stand Alone Treatmentioning

confidence: 99%

Guidelines for the management of oesophageal and gastric cancer

Allum

Griffin

Watson

et al. 2002

Gut

291

183

View full text Add to dashboard Cite

Section: Palliative Radiotherapy or Chemotherapy As Stand Alone Treatmentioning

confidence: 99%

Guidelines for the management of oesophageal and gastric cancer

Allum

Griffin

Watson

et al. 2002

Gut

291

183

View full text Add to dashboard Cite

“…In the present series, 29% patients had esophageal ulcerations after external radiation and intraluminal brachytherapy. Taal et al 38 reported 7% ulceration in their series. Fan et al 39 have reported a mortality rate of 13.6%, secondary to hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

“…Various authors have reported improved swallowing ranging from 56% to 96% for a variable period of time using the combination of intraluminal radiation at either a low or high dose rate and external beam radiation therapy 10 , 15 , 34 , 38 , 44 , 47 , 48 . In the present series, 43% of patients showed an improvement in swallowing and another 47% were able to maintain pretreatment swallowing.…”

Section: Discussionmentioning

confidence: 99%

Late esophageal toxicity using a combination of external beam radiation, intraluminal brachytherapy and 5-fluorouracil infusion in carcinoma of the esophagus

Sharma

Agarwal

Dinshaw

et al. 2008

Diseases of the Esophagus

View full text Add to dashboard Cite

One hundred patients with potentially curable squamous cell carcinoma of the esophagus were treated using a combination of external beam radiation, medium-dose intraluminal brachytherapy (ILBT), and 5-¯uorouracil infusion (as a radiosensitizer) from January 1990 to December 1993. The main objective was to determine late toxicity and optimization of the dose of intraluminal radiation. All patients had external radiation of 50 Gy over 5 weeks, followed by ILBT of 20 Gy for 50 patients (group 1) and 15 Gy for a subsequent 50 patients (group 2), using a dose rate of 315±330 cGy/h with the prescription at 1 cm o axis. The 5-¯uorouracil infusion was 500 mg/m 2 administered 12 h prior to ILBT. The treatment-related complications among groups 1 and 2 were strictures 24% vs. 8% (p=0.029), ulceration 30% vs. 28% (p=0.8), and tracheoesophageal ®stulae 12% for both groups. The overall survival for groups 1 and 2 was 8% and 23% at 5 years. The development of life-threatening complications is a major concern and extreme caution is urged before selecting patients for a combination of ILBT and 5-¯uorouracil treatment.

show abstract

“…At present, several treatment modalities are available for palliation of inoperable esophageal cancer. The treatment options most commonly used nowadays include stent placement [3,4,5,6,7], LASER therapy [8, 9], external beam irradiation combined with brachytherapy [10, 11] and brachytherapy as a single treatment (fig. 1) [12,13,14,15,16,17,18,19].…”

Section: Esophageal Cancermentioning

confidence: 99%

Palliative Radiation Therapy for Advanced Gastrointestinal Cancer

Murakami¹,

Nakagawa²,

Yamashita³

et al. 2008

Digestion

View full text Add to dashboard Cite

Patients with locally advanced disease can have significant local symptoms. The most common symptoms from local extension are pain, bleeding (hematemesis, melena) and obstruction (dysphagia, vomiting). These can cause a significant impact on a patient’s quality of life. Radiation therapy is used to control these symptoms with modern 3-dimensional conformal techniques or brachytherapy. The aim of this study was therefore to review the outcome of palliative radiation therapy in patients with symptomatic locally advanced or recurrent gastrointestinal cancer.

show abstract

High dose rate brachytherapy before external beam irradiation in inoperable oesophageal cancer

Cited by 33 publications

References 19 publications

Guidelines for the management of oesophageal and gastric cancer

Guidelines for the management of oesophageal and gastric cancer

Late esophageal toxicity using a combination of external beam radiation, intraluminal brachytherapy and 5-fluorouracil infusion in carcinoma of the esophagus

Palliative Radiation Therapy for Advanced Gastrointestinal Cancer

Contact Info

Product

Resources

About