High-dose stereotactic body radiotherapy using CyberKnife® for stage I peripheral lung cancer: a single-center retrospective study

Abstract

Background This retrospective study was performed to evaluate the efficacy and toxicity of high-dose stereotactic body radiotherapy (SBRT) using a CyberKnife® for patients with stage I peripheral non-small cell lung cancer (NSCLC). Methods Ninety-six patients with stage I peripheral NSCLC who were treated with SBRT using a CyberKnife® from August 2010 to June 2019 were identified and included in this study. Local control (LC), local progression-free survival (LPFS), progression-free survival (PFS), overall survival (OS), and late toxicity were evaluated. Potential risk factors associated with LC, LPFS, PFS, or OS were investigated by univariate analyses. Results Data of 96 patients were examined. The prescribed dose to the tumor was 54 Gy in 3 fractions in 91 patients and 60 Gy in 3 fractions in 5 patients. The median follow-up duration was 27 months. The 2-year LC, LPFS, PFS, and OS rates were 97%, 88%, 84%, and 90%, respectively. The T factor was significantly correlated with LC, LPFS, and PFS. The 2-year LC rate for patients with T1a/T1b and T1c/T2a disease was 100% and 90%, respectively (p < 0.05), and the 2-year PFS rate for the corresponding patients was 95% and 65%, respectively (p < 0.001). One patient (1%) developed grade 3 radiation pneumonitis. Conclusions High-dose SBRT using a CyberKnife® for stage I peripheral NSCLC produced favorable treatment outcomes with acceptable late toxicity. Further studies are needed to improve the treatment outcomes for patients with T1c/T2a disease.

Efficacy and toxicity of stereotactic body radiotherapy for un-resectable stage III non-small cell lung cancer patients unfit for concurrent chemoradiation therapy: a retrospective study

“…Stereotactic body radiotherapy (SBRT) includes a technology that can deliver higher dose and achieve higher BED through multiple radiation beams with steep dose gradient. At the same time, the new generation of machines including CyberKnife system allows accurate delivery of dose to the planned target volume (PTV), while protecting the surrounding healthy tissues [ 10 ]. Currently, SBRT has become the standard of care for patients with early-stage NSCLC who cannot be operated on.…”

“…More recently, Yasuhiro et al focused on CyberKnife-SBRT for Stage I peripheral NSCLC. The 2-year LC rate and PFS rate for patients with T1a/T1b and T1c/T2a disease was 100%, 90% and 95%, 65%, respectively [ 10 ]. The successful experience of SBRT in treating early cancer and the lessons learned from RTOG 0617 research will bring new insights into strategies to improve the effectiveness of local treatment [ 14 ].…”

Efficacy and toxicity of stereotactic body radiotherapy for un-resectable stage III non-small cell lung cancer patients unfit for concurrent chemoradiation therapy: A retrospective study

“…Stereotactic body radiotherapy (SBRT) includes a technology that can deliver higher dose and achieve higher BED through multiple radiation beams with steep dose gradient. At the same time, the new generation of machines including CyberKnife system allows accurate delivery of dose to the planned target volume (PTV), while protecting the surrounding healthy tissues [10]. Currently, SBRT has become the standard of care for patients with early-stage NSCLC who cannot operate.…”