High-Dose Vitamin D Intervention in Infants—Effects on Vitamin D Status, Calcium Homeostasis, and Bone Strength

Holmlund-Suila, Elisa; Viljakainen, Heli; Hytinantti, Timo; Lamberg‐Allardt, Christel; Andersson, Sture; Mäkitie, Outi

doi:10.1210/jc.2012-1575

Cited by 71 publications

(108 citation statements)

References 36 publications

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“…In comparison, 97% of breastfed infants living in Montreal and randomized at age 1 month to vitamin D 400, 800, 1200, or 1600 IU per day had a serum 25(OH)D concentration at age 3 months $20 ng/mL, as did almost all infants in Finland randomized at age 2 weeks to 400, 1200, or 1600 IU per day. 36,37 The lower percentages in our study are possibly due to differences in the enrolled populations. In the Canadian study .85% of mothers had completed tertiary education.…”

Section: Figurementioning

confidence: 54%

“…35,36 Vitamin D 1600 IU per day from age 2 weeks to 3 months does not cause hypercalcemia despite resulting in serum 25(OH)D concentrations up to 92 ng/mL. 37 Serum 25OHD concentrations at enrollment (4-80 ng/mL) spanned the expected range seen in populations without supplementation. 38 Recruitment was evenly distributed across seasons and the recruited sample included a diversity of skin pigmentation types.…”

Section: Figurementioning

confidence: 94%

“…The mothers of the Finnish infants were considered more health-orientated than the general population. 36,37 In comparison, our sample of mothers was less well educated (57% tertiary education) and comparable demographically to the region from which they were recruited. 48 …”

Section: Figurementioning

confidence: 99%

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Vitamin D During Pregnancy and Infancy and Infant Serum 25-Hydroxyvitamin D Concentration

Stewart

Scragg

Milne³

et al. 2014

Pediatrics

160

134

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WHAT'S KNOWN ON THIS SUBJECT: A serum 25-hydroxyvitamin D (25(OH)D) concentration of 20 ng/mL meets the requirements of at least 97.5% of the population older than 1 year. A recommended dietary intake to achieve this serum 25(OH)D concentration has not been established during infancy. WHAT THIS STUDY ADDS: METHODS:A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks' gestation to birth, and then their infants, from birth to age 6 months, were randomly assigned to 1 of 3 mother/infant groups: placebo/placebo, vitamin D 3 1000/400 IU, or vitamin D 3 2000/800 IU. Serum 25(OH)D and calcium concentrations were measured at enrollment, 36 weeks' gestation, in cord blood, and in infants at 2, 4, and 6 months of age.RESULTS: Two-hundred-and-sixty pregnant women were randomized. At enrollment, the proportions with serum 25(OH)D $20 ng/mL for placebo, lower-dose, and higher-dose groups were 54%, 64%, and 55%, respectively. The proportion with 25(OH)D $20 ng/mL was larger in both intervention groups at 36 weeks' gestation (50%, 91%, 89%, P , .001). In comparison with placebo, the proportion of infants with 25(OH)D $20 ng/mL was larger in both intervention groups to age 4 months: cord blood (22%, 72%, 71%, P , .001), 2 months (50%, 82%, 92%, P , .001), and 4 months (66%, 87%, 87%, P = .004), but only in the higher-dose group at age 6 months (74%, 82%, 89%, P = .07; higher dose versus placebo P = .03, lower dose versus placebo P = .21).

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Section: Figurementioning

confidence: 54%

Section: Figurementioning

confidence: 94%

See 1 more Smart Citation

Vitamin D During Pregnancy and Infancy and Infant Serum 25-Hydroxyvitamin D Concentration

Stewart

Scragg

Milne³

et al. 2014

Pediatrics

160

134

View full text Add to dashboard Cite

show abstract

“…However, subsequent studies found a higher probable effect on calcium metabolism, height involvement, and increased blood pressure. 54 Subsequent studies have found that a dose between 100 000 and 150 000 IU is enough to prevent VDD without known adverse effects.…”

Section: Vitamin D Deficiency Prevention In Children and Adolescentsmentioning

confidence: 99%

Vitamin D deficiency in pediatric clinical practice

Cediel¹,

Pacheco-Acosta

CastiUo-Durdn

2018

Arch Argent Pediatr

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Vitamin D research suggests it has a role in disorders other than bone metabolism. Objective: To update the information on vitamin D deficiency (VDD) in pediatric clinical disorders. Methods: Search in virtual libraries, giving priority to clinical and longitudinal studies and meta-analyses on VDD in the pediatric age group published in the past 20 years. The terms "vitamin D deficiency", "children and adolescents" (both in Spanish and English) were used as search descriptors. Results:In the pediatric population, VDD is associated with different clinical diseases, such as bone alterations, insulin resistance, metabolic syndrome, respiratory tract infections, asthma, and autoimmune diseases. Besides, it is associated with prematurity, obesity, malabsorption, use of anticonvulsant agents, and lifestyle characteristics, such as clothing, extreme latitudes, low consumption, and little sun exposure. Conclusions: According to the evidence, VDD is highly prevalent in several disorders and diseases in the pediatric age group. The recommendation is to prevent VDD in risk conditions and to maintain 25(OH)D serum levels > 75 nmol/L.

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“…Sin embargo, estudios posteriores encontraron una mayor probabilidad de efectos sobre el metabolismo del calcio, compromiso de talla y aumento de presión arterial. 54 Estudios posteriores han mostrado que dosis entre 100 000 y 150 000 UI son capaces de prevenir la DVD, sin efectos adversos demostrados. 55 En la Tabla 3, se muestran algunas recomendaciones para prevenir la DVD en población pediátrica.…”

Section: Prevención De La Deficiencia De Vitamina D En Niños Y Adolesunclassified

Deficiencia de vitamina D en la práctica clínica pediátrica

2018

Arch Argent Pediatr

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High-Dose Vitamin D Intervention in Infants—Effects on Vitamin D Status, Calcium Homeostasis, and Bone Strength

Abstract: Vitamin D3 supplementation with up to 40 μg/d from age 2 wk to 3 months was safe and caused no hypercalcemia or hypercalciuria. The 40-μg dose maintained S-25-OHD above 80 nmol/liter in all infants. More extensive and longer intervention studies are necessary to assess long-term effects.

Cited by 71 publications

References 36 publications

Vitamin D During Pregnancy and Infancy and Infant Serum 25-Hydroxyvitamin D Concentration

Vitamin D During Pregnancy and Infancy and Infant Serum 25-Hydroxyvitamin D Concentration

Vitamin D deficiency in pediatric clinical practice

Deficiencia de vitamina D en la práctica clínica pediátrica

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